Virchows Archiv

In this issue

ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants

Arnaud de la Fouchardiere, Willeke Blokx, Léon C. van Kempen, Boštjan Luzar, Sophie Piperno-Neumann, Susana Puig, Llucia Alos, Eduardo Calonje, Daniela Massi

Predictive significance of HER2 intratumoral heterogeneity, determined by simultaneous gene and protein analysis, for resistance to trastuzumab-based treatments for HER2-positive breast cancer

Rie Horii, Hiroaki Nitta, Masanori Nojima, Reo Maruyama, Takayuki Ueno, Yoshinori Ito, Shinji Ohno, Peter Banks, Hiroaki Kanda, Futoshi Akiyama

Assessment of HER2 using the 2018 ASCO/CAP guideline update for invasive breast cancer: a critical look at cases classified as HER2 2+ by immunohistochemistry

Valerie J. Taylor, Penny J. Barnes, Sean C. Godwin, Gillian C. Bethune

Morphological intratumor heterogeneity in ductal carcinoma in situ of the breast

Claudia Stanciu-Pop, Marie-Cécile Nollevaux, Martine Berlière, Francois P. Duhoux, Latifa Fellah, Christine Galant, Mieke R. Van Bockstal

Tumor budding in upper urinary tract urothelial carcinoma: a putative prognostic factor for extraurothelial recurrence and overall survival

Kazuki Kawamura, Kosuke Miyai, Junichi Asakuma, Kimiya Sato, Susumu Matsukuma, Hitoshi Tsuda, Keiichi Ito

Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma

José-Antonio Ortiz-Rey, Carmen Fachal, Laura Juaneda-Magdalena, Mónica Muñoz-Martín, Alfredo Repáraz-Andrade, Susana Teijeira, José-María Lamas-Barreiro, Sheila Almuster-Domínguez, Pilar San Miguel-Fraile, Carolina Gómez-de María

Primary MiNEN of the urinary bladder: an hitherto undescribed entity composed of large cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical behavior

Giacomo Maria Pini, Silvia Uccella, Matteo Corinti, Maurizio Colecchia, Giuseppe Pelosi, Carlo Patriarca

Cardiac hypertrophy at autopsy

Cristina Basso, Katarzyna Michaud, Giulia d’Amati, Jytte Banner, Joaquin Lucena, Kristopher Cunningham, Ornella Leone, Aryan Vink, Allard C. van der Wal, Mary N. Sheppard

Correction to: Cardiac hypertrophy at autopsy

Cristina Basso, Katarzyna Michaud, Giulia d’Amati, Jytte Banner, Joaquin Lucena, Kristopher Cunningham, Ornella Leone, Aryan Vink, Allard C. van der Wal, Mary N. Sheppard

Autopsy findings after long-term treatment of COVID-19 patients with microbiological correlation

Katja Evert, Thomas Dienemann, Christoph Brochhausen, Dirk Lunz, Matthias Lubnow, Markus Ritzka, Felix Keil, Matthias Trummer, Alexander Scheiter, Bernd Salzberger, Udo Reischl, Peter Boor, André Gessner, Jonathan Jantsch, Diego F. Calvisi, Matthias Evert, Barbara Schmidt, Michaela Simon

Biopsy pattern of invasion type to determine the surgical approach in early-stage oral squamous cell carcinoma

Yumei Pu, Liang Ding, Yujia Wang, Yuxin Wang, Sheng Chen, Xiaofeng Huang, Zhifeng He, Yanhong Ni, Qingang Hu

A novel evaluation method for Ki-67 immunostaining in paraffin-embedded tissues

Eliane Pedra Dias, Nathália Silva Carlos Oliveira, Amanda Oliveira Serra-Campos, Anna Karoline Fausto da Silva, Licínio Esmeraldo da Silva, Karin Soares Cunha

Mantle cell lymphomas with concomitant MYC and CCND1 breakpoints are recurrently TdT positive and frequently show high-grade pathological and genetic features

Sietse M. Aukema, Giorgio A. Croci, Susanne Bens, Kathrin Oehl-Huber, Rabea Wagener, German Ott, Andreas Rosenwald, Philip M. Kluin, Eva van den Berg, Anneke G. Bosga-Bouwer, Mels Hoogendoorn, Eva Hoster, Iris Bittmann, Inga Nagel, Eva M. Murga Penas, Markus Kreuz, Julia Bausinger, Wilfried Belder, Ilske Oschlies, Martin J. S. Dyer, Sandrine Jayne, Reiner Siebert, Wolfram Klapper

Novel partners of USP6 gene in a spectrum of bone and soft tissue lesions

Mélanie Legrand, Marie-Lise Jourdan, Anne Tallet, Christine Collin, Virginie Audard, Frédérique Larousserie, Sébastien Aubert, Anne Gomez-Brouchet, Corinne Bouvier, Gonzague de Pinieux

Undifferentiated large cell/rhabdoid carcinoma presenting in the intestines of patients with concurrent or recent non-small cell lung cancer (NSCLC): clinicopathologic and molecular analysis of 14 cases indicates an unusual pattern of dedifferentiated metastases

Abbas Agaimy, Ondrej Daum, Michal Michal, Mona W. Schmidt, Robert Stoehr, Arndt Hartmann, Gregory Y. Lauwers

Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients

Yasuhiro Wada, Shigemi Nakajima, Ryoji Kushima, Shizuki Takemura, Naoko Mori, Hiroshi Hasegawa, Takahisa Nakayama, Ken-ichi Mukaisho, Akiko Yoshida, Shinji Umano, Kazuo Yamamoto, Hiroyuki Sugihara, Kazunari Murakami

Simple mucinous cyst: another potential cancer precursor in the pancreas? Case report with molecular characterization and systematic review of the literature

Anna Caterina Milanetto, Alice Sabrina Tonello, Giovanni Valotto, Giada Munari, Claudio Luchini, Matteo Fassan, Claudio Pasquali

Insulinoma-associated protein 1 (INSM1) expression in breast carcinomas with neuroendocrine morphologies: application and future prospective

Tomonori Kawasaki, Kyoichi Kaira

Expanding spectrum of “spitzoid” lesions: a small series of 4 cases with MAP2K1 mutations

K. G. P. Kerckhoffs, T. Aallali, C. A. Ambarus, V. Sigurdsson, A. M. L. Jansen, W. A. M. Blokx

Co-existence of lung carcinoma metastasis and enchondroma in the femur of a patient with Ollier disease

Xudong Wang, Xiaohui Zhang, Wenling Pan, Yuedong Han, Yanwei Li, Haibin Sun, Pancras C. W. Hogendoorn, Hong Cheng

CD73 expression in normal, hyperplastic, and neoplastic thyroid: a systematic evaluation revealing CD73 overexpression as a feature of papillary carcinomas

Inês Monteiro, Edoardo Missiaglia, Amedeo Sciarra, João Vasco Santos, Justine Bouilly, Pedro Romero, Christine Sempoux, Laurence de Leval

A multilocular thymic cyst associated with mediastinal seminoma: evidence for its medullary epithelial origin highlighted by POU2F3-positive thymic tuft cells and concomitant myoid cell proliferation

Akihiko Sugimoto, Yosuke Yamada, Masakazu Fujimoto, Sachiko Minamiguchi, Takuma Sato, Shusuke Akamatsu, Alexander Marx, Hironori Haga

Malignant salivary gland tumours in families with breast cancer susceptibility

Carla B. Ripamonti, Paolo Bossi, Siranoush Manoukian, Laura Locati, Mara Colombo, Maria L. Carcangiu, Andrea Vingiani, Lisa Licitra, Paolo Radice

Lesson from the COVID-19 pandemic: pathologists need to build their confidence on working in a digital microscopy environment

Rodolfo Montironi, Alessia Cimadamore, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli