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Systemic Therapy 

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  1. 09-04-2024 | Prostate Cancer | ReviewPaper

    Current Systemic Therapy in Men with Metastatic Castration-Sensitive Prostate Cancer

    Prostate cancer (PC) is the second most frequent cancer in men worldwide with an incidence of 1,414,259 new cases and 375,304 deaths in 2020 [ 1 ]. Although the majority of men are diagnosed with localised disease in Western countries, up to …

  2. 28-04-2024 | Breast Cancer | Online First

    Determining individual suitability for neoadjuvant systemic therapy in breast cancer patients through deep learning

    Breast cancer stands as the most prevalent malignant tumor in women worldwide [ 1 ]. Contemporary treatment strategies employ a multimodal approach integrating surgery, endocrine therapy, chemotherapy, and radiotherapy [ 2 ]. Beyond selecting the …

  3. 22-03-2024 | Esophagus Resection | EditorialNotes

    Finding the Optimal Time to Esophagectomy After Systemic Therapy Would be Finding a Lost Princess or Prince

  4. Open Access 07-04-2024 | Esophageal Varices | Online First

    Clinical risk factors for portal hypertension-related complications in systemic therapy for hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) remains an important cause of cancer-related mortality, and in recent years, its incidence has continued to incline [ 1 ]. Most patients with HCC are diagnosed with stage B or C in the Barcelona Clinic Liver Cancer …

  5. 01-04-2024 | Colchicine | Letter

    High systemic inflammation as a novel cardiovascular risk factor and target for anti-cytokine therapy: comment regarding the triglyceride glucose index

    In the last century, there has been more than enough research that proved the association of high lipid and glucose levels with cardiovascular disease, thus establishing the current well-known traditional cardiovascular risk factors such as …

  6. 02-03-2024 | Neuroendocrine Tumor | Online First

    Systemic Therapy for Pancreatic Neuroendocrine Tumors

    Pancreatic neuroendocrine tumors (PanNETs) account for approximately 2% of all pancreatic malignancies. Several systemic treatment options have been developed over the last four decades, ranging from cytotoxic chemotherapy and octreotide to newer …

  7. 21-03-2024 | Tuberculosis | Online First

    Screening and treatment of latent tuberculosis in patients with solid tumors and systemic cancer therapy

    Tuberculosis is one of the infectious diseases causing more morbidity and mortality in the world. About 10 million new cases of active infection and between 1.5 and 2 million deaths are estimated annually, overcoming other infectious diseases such …

  8. Open Access 01-12-2024 | Magnetic Resonance Imaging | OriginalPaper

    Outcomes of sentinel node biopsy according to MRI response in an association with the subtypes in cN1–3 breast cancer after neoadjuvant systemic therapy, multicenter cohort study

    Neoadjuvant systemic therapy (NAST) is widely adopted as the standard of care for patients with clinical stage II–III breast cancer [ 1 – 3 ]. Advancements in NAST, such as human epidermal growth factor receptor 2 (HER2)-targeted therapy or …

  9. 10-01-2024 | Enzalutamide | OriginalPaper

    Cost-Effectiveness Analysis of Systemic Therapy for Intensification of Treatment in Metastatic Hormone-Sensitive Prostate Cancer in India

    As per the latest estimates, prostate cancer (PC) has the fifth highest incidence rate among male individuals in India (4.8 per 100,000) [ 1 ]. Prostate cancer features among the top ten cancers in urban cancer registries of Bangalore, Delhi …

  10. 09-04-2024 | Breast Cancer | Online First

    Can neoadjuvant systemic therapy provide additional benefits for T1 HER2+ breast cancer patients: a subgroup analysis based on different high-risk signatures

    Human epidermal growth factor receptor type 2 (HER2), a member of the human epidermal growth factor receptor family, serves as a transmembrane protein binding to cell surface molecules and plays a crucial role in mediating cell proliferation [ 1 …

  11. 10-02-2024 | Systemic Therapy | BriefCommunication

    ASO Author Reflections: Neoadjuvant Systemic Therapy and Nodal Management in cT1-2 N0 Triple-Negative Breast Cancer

    Neoadjuvant chemotherapy (NAC) for breast cancer has traditionally been used to downstage the primary breast tumor in an effort to facilitate breast-conserving surgery or to downstage the clinically positive axilla in hopes of sparing those who …

  12. Open Access 01-12-2024 | Graft-Versus-Host Disease | OriginalPaper

    A phase II study of belumosudil for chronic graft-versus-host disease in patients who failed at least one line of systemic therapy in China

    Chronic graft-versus-host disease (cGVHD), an immune-related disorder characterized by inflammation and fibrosis, is a common cause of morbidity and non-relapse mortality following allogenic hematopoietic stem cell transplant (allo-HSCT) [ 1 – 3 ].

  13. Open Access 05-03-2024 | Lenvatinib | OriginalPaper

    Incidence and Costs of Clinically Significant Events with Systemic Therapy in Patients with Unresectable Hepatocellular Carcinoma: A Retrospective Cohort Study

    Liver cancer is one of the most common fatal malignancies and was the third leading cause of cancer-related deaths worldwide in 2020 [ 1 ]. Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for approximately 90% of …

  14. Open Access 09-12-2023 | Breast Cancer | OriginalPaper

    Validation of prognostic and predictive value of total tumoral load after primary systemic therapy in breast cancer using OSNA assay

    Neo-adjuvant systemic treatment (NAST) is currently being used as a preoperative treatment modality in early-stage breast cancer (BC), offering the opportunity to further de-escalate the surgical management of the axilla in patients undergoing BC …

  15. Open Access 01-02-2024 | Systemic Therapy | OriginalPaper

    Budget Impact of Introducing Fixed-Duration Mosunetuzumab for the Treatment of Relapsed or Refractory Follicular Lymphoma After Two or More Lines of Systemic Therapy in the USA

    Non-Hodgkin lymphomas (NHLs) are a group of heterogeneous neoplasms of the lymphoid system that vary from the most indolent to the most aggressive malignancies [ 1 – 3 ]. In the USA, 788,781 people were living with NHL in 2020, and it was estimated …

  16. Open Access 01-12-2024 | Systemic Therapy | OriginalPaper

    The therapeutic effect of radiotherapy combined with systemic therapy compared to radiotherapy alone in patients with simple brain metastasis after first-line treatment of limited-stage small cell lung cancer: a retrospective study

    Small cell lung cancer (SCLC) is a highly aggressive malignant tumor, accounting for approximately 15% of all lung cancers [ 1 ]. Although most SCLC patients have high sensitivity to initial chemotherapy (CT) and radiotherapy (RT), most patients …

  17. Open Access 01-12-2024 | Systemic Therapy | OriginalPaper

    Systemic therapy in children and adolescents with mental disorders: a systematic review and meta-analysis

    Systemic therapy (ST) or systems-oriented therapy can be defined as a psychotherapeutic intervention in complex human systems (both psychological and interpersonal) [ 1 ]. ST focuses on relationships and interactions, and include a contextual view …

  18. 08-03-2024 | Antibiotic | Online First

    Influence of systemic antibiotic therapy on the development and progression of induced apical periodontitis in Wistar rats

    The aim of this study was to investigate the influence of systemic antibiotic therapy on the development and progression of induced apical periodontitis (AP) in Wistar rats. Fifty-six rats were submitted to pulp exposure of the lower left first …

  19. 12-03-2024 | Prostate Cancer | Online First

    [177Lu]Lu-PSMA-617 as first-line systemic therapy in patients with metastatic castration-resistant prostate cancer: a real-world study

    Prostate cancer (PCa) currently holds the top position among cancers affecting males, with an estimated 288,300 new cases and 34,700 deaths projected in the United States for the year 2023 [ 1 ]. Approximately 10–20% of PCa patients progress to …

  20. 01-02-2024 | Craniopharyngioma | ReviewPaper

    Integrating Systemic Therapies into the Multimodality Therapy of Patients with Craniopharyngioma

    The integration of targeted therapy into the multimodal management of craniopharyngiomas represents a significant advancement in the field of neuro-oncology. Historically, the management of these tumors has been challenging due to their proximity …

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