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Photodermatosis 

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  1. Open Access 22-01-2024 | OriginalPaper

    Splice-Modulating Antisense Oligonucleotides as Therapeutics for Inherited Metabolic Diseases

    The last decade (2013–2023) has seen unprecedented successes in the clinical translation of therapeutic antisense oligonucleotides (ASOs). Eight such molecules have been granted marketing approval by the United States Food and Drug Administration …

  2. Open Access 30-06-2023 | Idiopathic Pulmonary Fibrosis | OriginalPaper

    Efficacy and Safety of Pirfenidone in Advanced Versus Non-Advanced Idiopathic Pulmonary Fibrosis: Post-Hoc Analysis of Six Clinical Studies

    Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrosing interstitial lung disease that is characterized by progressive worsening of dyspnea and lung function, and has a poor prognosis [ 1 – 3 ]. In general, the progression of IPF is not linear …

  3. 01-09-2019 | Protoporphyria | ReviewPaper

    Solar Urticaria

    Solar urticaria (SU) is a rare photodermatosis. It is also a type of inducible (physical) urticaria characterized by an abrupt onset of transient erythema, wheals, and pruritus appearing within minutes of exposure to light (Fig. 1 ) [ 1 •]. Lesions …

  4. 03-01-2024 | Systemic Lupus Erythematosus | ReviewPaper

    An overlapping case of IgG4-related disease and systemic lupus erythematosus treated with belimumab: a case-based review

    IgG4-related disease (IgG4-RD) is a systemic condition in which IgG4+ plasma cell infiltration and fibrosis cause organ swelling and lead to diverse clinical manifestations. Although IgG4-RD typically responds to glucocorticoids (GCs), relapse …

  5. 28-11-2022 | Melasma | ReviewPaper

    Review on photoprotection: a clinician’s guide to the ingredients, characteristics, adverse effects, and disease-specific benefits of chemical and physical sunscreen compounds

    Photoprotection is a critical health prevention strategy to reduce the deleterious effects of ultraviolet radiation (UVR) and visible light (VL). Methods of photoprotection are reviewed in this paper, with an emphasis on sunscreen. The most …

  6. 23-09-2023 | Cytokines | OriginalPaper

    Deficiency of N6-Methyladenosine Demethylase ALKBH5 Alleviates Ultraviolet B Radiation-Induced Chronic Actinic Dermatitis via Regulating Pyroptosis

    Pyroptosis is an inflammatory programmed cell death (PCD) and is reported to be associated with N6-methyladenosine (m6A) modification. This study aimed to investigate the mechanism of m6A demethylase AlkB homolog 5 (ALKBH5) in pyroptosis in the …

  7. Open Access 01-12-2020 | Porphyria Cutanea Tarda | OriginalPaper

    Health-related quality of life in porphyria cutanea tarda: a cross-sectional registry based study

    Porphyria cutanea tarda (PCT) is the most common form of porphyria worldwide, with an estimated prevalence of symptomatic disease of 10:100000 [ 1 , 2 ]. The disease is caused by an inherited (familial PCT) or acquired (sporadic PCT) defect in the …

  8. Open Access 26-07-2023 | Photodermatosis | ReviewPaper

    Reinforcing Photoprotection for Skin of Color: A Narrative Review

    Skin of color (SOC) is characterized by increased tendency for tanning and decreased likelihood of sunburns due to the attenuation of sunlight by epidermal melanin. Although this contributes to the decreased incidence of skin cancer among SOC …

  9. 01-09-2019 | Photodermatosis | ReviewPaper

    Polymorphous Light Eruption: a Review

    Polymorphous light eruption (PMLE), also known as polymorphic light eruption, is an immunologically mediated photodermatosis with a high prevalence of up to 10–20%, making it the most common photodermatosis worldwide [ 1 – 4 ]. PMLE most often …

  10. 30-07-2022 | Neutropenia | OriginalPaper

    Impact of osteopenia and neutropenia in patients with colorectal cancer treated with FOLFOXIRI: a retrospective cohort study

    FOLFOXIRI is a triplet chemotherapy regimen including fluorouracil, leucovorin, oxaliplatin, and irinotecan. Several randomized clinical trials have revealed the efficacy and safety of FOLFOXIRI [ 1 – 3 ]. These trials showed that FOLFOXIRI …

  11. Open Access 01-02-2022 | Immunomodulator | Report

    Pirfenidone in Unclassifiable Interstitial Lung Disease: A Subgroup Analysis by Concomitant Mycophenolate Mofetil and/or Previous Corticosteroid Use

    Interstitial lung diseases (ILDs) are a large, heterogeneous group of diseases characterized by abnormalities of pulmonary interstitium or alveoli, including fibrosis [ 1 ]. Although some ILDs have a progressive fibrosing phenotype similar to …

  12. Open Access 18-06-2022 | Photodermatosis | OriginalPaper

    Prevention of Polymorphic Light Eruption Afforded by a Very High Broad-Spectrum Protection Sunscreen Containing Ectoin

    Polymorphic light eruption (PLE) is the most common photosensitivity disorder in white Caucasians, affecting 11–21% of the population in the Northern Hemisphere, especially affecting more women than men in their second to third decade of life. It …

  13. 01-12-2019 | Allergic Contact Dermatitis | ReviewPaper

    Photoallergic Contact Dermatitis

    Photoallergic contact dermatitis (PACD) is a rare photodermatosis that is caused by the direct exposure of the skin with causative pre-sensitizer agents in combination with UVA (315-400 nm) and occasionally visible light (400–700 nm) [ 1 , 2 ].

  14. 01-09-2019 | Allergic Contact Dermatitis | ReviewPaper

    Chronic Actinic Dermatitis: a Review

    Chronic actinic dermatitis (CAD) is an immunologically mediated photodermatosis characterized by pruritic eczematous lesions of sun-exposed areas [ 1 – 3 ] . CAD was previously known as actinic reticuloid, photosensitive eczema, photosensitive …

  15. Open Access 22-12-2022 | OriginalPaper

    Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study

    Skin aging was considered for years an aesthetic concern but with the increase in life expectancy, the functional impact of aging has been emphasized [ 1 , 2 ] …

  16. 01-03-2020 | Systemic Lupus Erythematosus | OriginalPaper

    Successful treatment of non-HIV progressive multifocal leukoencephalopathy: case report and literature review

    Progressive multifocal leukoencephalopathy (PML) is a subacute-onset demyelinating disease caused by JC virus (JCV) that usually affects individuals with immunosuppressed conditions and is characterized by multifocal involvement of the subcortical …

  17. 01-12-2013 | OriginalPaper

    Bone mineral density and vitamin D levels in erythropoietic protoporphyria

    Erythropoietic protoporphyria (EPP) is a rare disease with painful cutaneous photosensitivity, in which patients are recommended to avoid sun exposure, and wear sunscreen and adequate clothing. Our aim was to study bone mineral density (BMD) and …

  18. 01-10-2015 | BriefCommunication

    Photosensitivity with Angiotensin II Receptor Blockers: A Retrospective Study Using Data from VigiBase®

    In susceptible patients, the interaction between sunlight and medications may lead to photosensitivity reactions, either in the form of a phototoxic reaction or photoallergy. Phototoxicity is defined as an acute light-induced tissue response to a …

  19. 01-10-2018 | ReviewPaper

    Recent Developments in the Diagnosis and Management of Photosensitive Disorders

    Photodermatoses occur in males and females of all races and ages. Onset can be variable in timing and influenced by genetic and environmental factors. Photodermatoses are broadly classified as immunologically mediated, chemical- and drug-induced …

  20. 01-06-2020 | OriginalPaper

    Fluoroquinolone-Induced Photosensitivity: A Chemical Fragment-Based Approach by a Case/Non-case Study in VigiBase®

    Fluoroquinolones are antibiotics widely used to treat bacterial infections. Modifications of the common chemical structure can affect their properties such as the antibacterial spectrum, the genetic toxicity, or their photosensitivity reactions …

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