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Hormone Therapy 

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  1. 18-05-2024 | Positron Emission Tomography | Online First

    The effect of hormone therapy on physiological uptake of the endometrium on [18F]F-FDG PET in postmenopausal women

    Hormone replacement therapy (HRT), i.e. estrogen with or without progestin, is used for perimenopausal women to prevent and treat the symptoms and physical changes caused by estrogen deficiency, vasomotor symptoms, urogenital system atrophy …

  2. Open Access 06-04-2024 | Androgens | ReviewPaper

    Impact of disease volume on survival efficacy of triplet therapy for metastatic hormone-sensitive prostate cancer: a systematic review, meta-analysis, and network meta-analysis

    The treatment landscape of metastatic hormone-sensitive prostate cancer (mHSPC) is rapidly changing [ 1 – 4 ]. Adding an androgen receptor signaling inhibitor (ARSI) with or without docetaxel to androgen deprivation therapy (ADT) is the current …

  3. 25-04-2024 | Urinary Incontinence | Online First

    Pelvic Floor Dysfunction in Transgender Men on Gender-affirming Hormone Therapy: A Descriptive Cross-sectional Study

    Transgender people often seek medical care to obtain masculinization or feminization hormone therapy to modify their external physical appearance to align with their gender identity [ 1 , 2 ]. A transgender man is a person who, at birth, was …

  4. 02-04-2024 | Estrogens | ReviewPaper

    Inflammation as a Potential Mechanism Contributing to Sexual Functioning Following Initiation of Gender-Affirming Hormone Therapy

    The CDC estimates that 60–70% of transgender and gender non-conforming (TGNC) people in the United States receive some form of gender-affirming hormone therapy (GAHT; [ 1 ], see [ 2 ] for a community sample). Substantial research on GAHT …

  5. Open Access 05-05-2024 | Breast Cancer | Online First

    Correction: Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study

  6. Open Access 01-12-2024 | Apalutamide | OriginalPaper

    Protocol for CHAMPION study: a prospective study of maximal-cytoreductive therapies for patients with de novo metastatic hormone-sensitive prostate cancer who achieve oligopersistent metastases during systemic treatment with apalutamide plus androgen deprivation therapy

    Prostate cancer is a lethal disease especially when progressing into a metastatic status [ 1 , 2 ]. The proportion of patients with newly diagnosed prostate cancer at advanced stages is higher in China than in Western countries, and most patients …

  7. Open Access 20-01-2024 | Breast Cancer | OriginalPaper

    Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study

    Several risk scoring methods are available to support decision-making for adjuvant therapy in breast cancer to assess which patients could be spared or would benefit from adjuvant cytotoxic therapy, to avoid over- and under-treatment …

  8. 21-11-2023 | Sexually Transmitted Infection | OriginalPaper

    Decreased Anogenital Gonorrhea and Chlamydia in Transgender and Gender Diverse Primary Care Patients Receiving Gender-Affirming Hormone Therapy

    In the United States (U.S.), transgender and gender diverse (TGD) adults—those whose gender identity does not correspond to their sex assigned at birth—are highly burdened by sexually transmitted infections (STIs). 1 An international review of STI …

  9. Open Access 28-11-2023 | Hypothyroidism | Review

    Risks of suboptimal and excessive thyroid hormone replacement across ages

    Undertreatment and overtreatment of hypothyroidism can have serious consequences at all ages, from poor growth and development in undertreated children to an increased risk of cardiac death in overtreated adults.

  10. Open Access 21-04-2024 | Minoxidil | Online First

    Efficacy of topical minoxidil in enhancing beard growth in a group of transgender assigned female at birth individuals on gender affirming hormone therapy

    Gender Incongruence relates to a marked and persistent incongruence between an individual’s experienced gender and the assigned gender at birth [ 1 ]. To align a person’s body with their gender identity, transgender and gender diverse (TGD) people …

  11. Open Access 24-04-2024 | Mastectomy | Online First

    The effects of gender-affirming hormone therapy and mastectomy on psychopathology, body image, and quality of life in adults with gender dysphoria who were assigned female at birth

    Individuals with gender dysphoria (GD) experience a discrepancy between their assigned sex at birth and gender identity [ 1 ], necessitating various medical interventions to align the characteristics of their desired gender with their body [ 2 ].

  12. 10-01-2024 | Enzalutamide | OriginalPaper

    Cost-Effectiveness Analysis of Systemic Therapy for Intensification of Treatment in Metastatic Hormone-Sensitive Prostate Cancer in India

    As per the latest estimates, prostate cancer (PC) has the fifth highest incidence rate among male individuals in India (4.8 per 100,000) [ 1 ]. Prostate cancer features among the top ten cancers in urban cancer registries of Bangalore, Delhi …

  13. Open Access 12-01-2024 | Sarcoidosis | OriginalPaper

    Menopausal hormone therapy and risk of sarcoidosis: a population-based nested case–control study in Sweden

    Sarcoidosis incidence peaks in women between 50 and 60 years old, which coincides with menopause, suggesting that certain sex hormones, mainly estrogen, may play a role in disease development. We investigated whether menopausal hormone therapy

  14. 07-03-2024 | Breast Cancer | Online First

    Genomic Testing to Guide Local Therapy Decisions in Hormone Receptor-Positive Breast Cancer

    The focus on personalizing breast cancer care has come a long way with the development of genomic tests which consist of multi-gene signatures translating into a genomic risk category or score. These genomic tests have improved risk stratification …

  15. 22-12-2023 | Sleep Apnea | ReviewPaper

    The outcomes of growth hormone therapy in the obstructive sleep apnea parameters of Prader–Willi syndrome patients: a systematic review

    Prader–Willi syndrome (PWS) is a pathology with an estimated prevalence of around 1/10,000–1/30,000 births, caused by the absence of expression of genes from the region 15q11–q13 of the 15 chromosome [ 1 , 2 ] Among the consequences for the …

  16. Open Access 18-01-2024 | Raloxifene | Online First

    Antiosteoporosis therapy after discontinuation of menopausal hormone therapy: a systematic review

    Estrogen exerts a beneficial role in bone metabolism, mainly indirectly by preventing bone resorption via estrogen receptor (ER) β through the osteoprotegerin (OPG)/receptor activator of the NF-κB (RANK)/RANK ligand (RANKL) axis [ 1 ]. Estrogens …

  17. 01-02-2024 | OriginalPaper

    Pituitary Stalk Interruption Syndrome: Analysis of Response to Growth Hormone Therapy

  18. 21-11-2023 | Language Development | ReviewPaper

    Early psychomotor development and growth hormone therapy in children with Prader-Willi syndrome: a review

    Prader-Willi syndrome (PWS) is a rare genetic disorder caused by the loss of imprinted gene expression on the paternal chromosome 15q11-q13. PWS is characterized by varying degrees of early psychomotor developmental deficits, primarily in …

  19. Open Access 20-04-2024 | Breast Cancer | Online First

    Real-world progression-free survival and overall survival of palbociclib plus endocrine therapy (ET) in Japanese patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer in the first-line or second-line setting: an observational study

    Despite substantial advances in therapy, advanced breast cancer (ABC) remains an incurable disease with a 5-year survival rate of ~ 25% [ 1 ]. Of the different disease subtypes, hormone receptor-positive (HR+)/human epidermal growth factor receptor …

  20. 01-02-2024 | Testosterone | Online First

    Persistent vaginal bleeding during gender-affirming hormone therapy in transgender men

    This study highlights the potential benefits of maintaining testosterone levels within physiological ranges, as it may help prevent breakthrough bleeding. However, the impact of testosterone on the endometrium of transgender men remains uncertain.

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