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Granulomatous Disorder 

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  1. Open Access 01-12-2022 | Granulomatous Disorder | OriginalPaper

    Non-infectious granulomatous disorders of the upper lip: clinicopathological analysis of 11 patients

    “Granuloma” is a specific histopathological form of chronic inflammation, of which two main groups are classically recognised: foreign body granulomas and immune granulomas [ 1 ]. Morphologically, the granuloma appears as a round-ovoid formation …

  2. 01-02-2022 | Granulomatous Disorder

    The Relationship Between Mucosal Microbiota, Colitis, and Systemic Inflammation in Chronic Granulomatous Disorder

    Chronic granulomatous disorder (CGD) is a primary immunodeficiency characterized by failure of phagocyte oxidative burst [ 1 ]. In addition to life-threatening infection, affected patients frequently suffer inflammatory colitis [ 2 ], characterized …

  3. 01-01-2019 | Ataxia Telangiectasia | OriginalPaper

    Rubella Virus-Associated Cutaneous Granulomatous Disease: a Unique Complication in Immune-Deficient Patients, Not Limited to DNA Repair Disorders

    The association of immunodeficiency-related vaccine-derived rubella virus (iVDRV) with cutaneous and visceral granulomatous disease has been reported in patients with primary immunodeficiency disorders (PIDs). The majority of these PID patients …

  4. Open Access 01-07-2019 | Granulomatous Disorder | OriginalPaper

    Chronic Granulomatous Disorder–Associated Colitis Can Be Accurately Evaluated with MRI Scans and Fecal Calprotectin Level

    Chronic granulomatous disorder (CGD) is a primary immunodeficiency caused by mutations in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme complex [ 1 ]. Affected individuals suffer recurrent infection with bacterial and …

  5. 01-04-2016 | ReviewPaper

    Gastrointestinal Disorders Associated with Common Variable Immune Deficiency (CVID) and Chronic Granulomatous Disease (CGD)

    Common variable immune deficiency (CVID) and chronic granulomatous disease (CGD) are two of the well-characterized primary immune deficiencies with distinct pathologic defects. While CVID is predominantly a disorder of the adaptive immune system …

  6. 01-10-2000 | OriginalPaper

    Chronic granulomatous disease and other disorders of neutrophil function

  7. 01-02-2010 | OriginalPaper

    Hematopoetic Stem Cell Transplantation in Neutrophil Disorders: Severe Congenital Neutropenia, Leukocyte Adhesion Deficiency and Chronic Granulomatous Disease

    Until further progress will occur in the field of gene therapy, the only curative treatment available in severe congenital neutropenia, leukocyte adhesion deficiency, and chronic granulomatous disease is allogeneic hematopoietic stem cell …

  8. Open Access 01-12-2010 | OriginalPaper

    Investigation of Toll-like receptors in the pathogenesis of fibrotic and granulomatous disorders: a bronchoalveolar lavage study

    Interstitial lung diseases (ILDs) include a wide spectrum of disorders, many of which are uncommon and many of unknown etiology. Pathogenesis of idiopathic and autoimmune fibrotic lung diseases as well as granulomatous lung disorders still remains …

  9. 01-06-2024 | Thrombocytopenia | OriginalPaper

    Immune Thrombocytopenic Purpura (ITP) and Chorioretinopathy in Chronic Granulomatous Disease: A Case Report

    Chronic Granulomatous Disease (CGD) is a rare inherited immunodeficiency disorder characterized by impaired phagocytic function, rendering affected individuals susceptible to recurrent and severe bacterial and fungal infections and granuloma …

  10. 18-05-2024 | Sarcoidosis | Online First

    Neuropathological evidence for neurosarcoidosis is more widespread than imaging suggests

    We present a single case of a 47 year old male with a relapsing progressive neurological disease characterised by an infiltrative inflammation of the brain and leptomeninges. Investigations revealed the presence of systemic sarcoidosis which was …

  11. 01-12-2022 | Bronchiectasis | OriginalPaper

    Imaging Findings in Chronic Granulomatous Disease (CGD)

    Chronic granulomatous disease (CGD) is a rare inherited disorder of neutrophil function [ 1 – 4 ]. It is caused by mutations in one of four genes encoding subunits of the phagocyte NADPH (nicotinamide adenine dinucleotide phosphate oxidase). In CGD …

  12. Open Access 24-08-2023 | Graft-Versus-Host Disease | OriginalPaper

    Allogeneic HSCT for Symptomatic Female X-linked Chronic Granulomatous Disease Carriers

    X-linked chronic granulomatous disease (XL-CGD) is an inherited disorder of superoxide production, causing failure to generate the oxidative burst in phagocytes. It is characterized by invasive bacterial and fungal infections, inflammation, and …

  13. 14-05-2024 | Pyoderma Gangrenosum | Online First

    Approach to the Atypical Wound

    The heterogeneity of atypical wounds can present diagnostic and therapeutic challenges; however, as the prevalence of atypical wounds grows worldwide, prompt and accurate management is increasingly an essential skill for dermatologists. Addressing …

  14. Open Access 11-07-2023 | OriginalPaper

    Chronic Granulomatous Disease: a Cohort of 173 Patients—10-Years Single Center Experience from Egypt

    Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder (PID) of phagocytes, characterized by a defect of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase components [ 1 , 2 ]. These are responsible for the …

  15. 31-05-2023 | Atrioventricular Block | OriginalPaper

    FDG-PET/CT and rest myocardial perfusion imaging to predict high-degree atrioventricular block recovery in cardiac sarcoidosis

    Sarcoidosis is a multisystem disorder of unknown origin characterised by granulomatous inflammation. 1 Cardiac sarcoidosis (CS) may accompany multisystem manifestations or, less frequently, occur in isolation. 2 Clinical presentation of CS varies …

  16. 20-03-2024 | Events

    Abstracts

  17. Open Access 01-12-2023 | Sarcoidosis | OriginalPaper

    SACE and IL-2R as serum biomarkers for evaluation of multi-organ involvement and prognosis of sarcoidosis

    Sarcoidosis is a systemic granulomatous disorder of unknown etiology that may affect almost every body organ. The most commonly involved organs remain the lung and mediastinal lymph nodes. The incidence of sarcoidosis varies due to different …

  18. Open Access 01-06-2024 | Epstein-Barr Virus | OriginalPaper

    Development of EBV Related Diffuse Large B-cell Lymphoma in Deficiency of Adenosine Deaminase 2 with Uncontrolled EBV Infection

    Deficiency of Adenosine Deaminase 2 (DADA2) patients presenting with primary immunodeficiency are at risk of uncontrolled EBV infection and secondary malignancies including EBV-related lymphoproliferative disorders (LPD). This paper describes the …

  19. 01-12-2023 | Crohn's Disease | OriginalPaper

    Temporal trends in surgery for Crohn’s disease: a ten-year single-center retrospective study

    Crohn’s disease (CD) is a chronic inflammatory bowel disorder characterized by the presence of transmural granulomatous inflammation, which can manifest in any segment of the gastrointestinal tract. In recent decades, the medical armamentarium …

  20. 17-04-2024 | Granulomatosis with Polyangiitis | Online First

    Management of granulomatosis with polyangiitis complicated by intestinal perforation and pancytopenia: a case report and literature review

    Granulomatosis with polyangiitis is a systemic vasculitis. While the classic triad typically comprises otorhinolaryngologic, pulmonary, and renal manifestations, it is essential to recognize that granulomatosis with polyangiitis can affect any …

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