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Antiviral Agents 

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  1. 18-03-2024 | Hepatocellular Carcinoma | Online First

    Hepatocellular Carcinoma in the Era of Direct Antiviral Agents Against Hepatitis C Virus

    The hepatitis C virus (HCV), a single-stranded RNA virus belonging to the Flaviviridae family, is globally responsible for more than 150,000 deaths from hepatocellular carcinoma (HCC), every year [ 1 ]. This is the inevitable consequence of 58.5 …

  2. 20-09-2023 | Hepatitis C | ReviewPaper

    Mechanisms and Clinical Significance of Pharmacokinetic Drug Interactions Mediated by FDA and EMA-approved Hepatitis C Direct-Acting Antiviral Agents

    The treatment of patients infected with the hepatitis C virus (HCV) has been revolutionised by the development of direct-acting antiviral agents (DAAs) that target specific HCV proteins involved in viral replication. The first DAAs were associated …

  3. 13-12-2022 | Vasculitis | OriginalPaper

    HIV-associated multiple intracranial aneurysms and stroke in an adult patient: successful treatment with a combination of glucocorticoid and antiviral agents

    A 35-year-old Iranian man with an 18-year history of human immunodeficiency virus (HIV) infection developed sudden left-sided hemiparesis and mild dysarthria. Based on laboratory results, brain and neck computerized tomography angiography (CTA) …

  4. Open Access 06-04-2023 | Hepatitis B | OriginalPaper

    Hepatitis C and hepatitis B virus infection in hemodialysis patients after nationwide direct antiviral agents therapy—experience of 10 Romanian HD centers

    The high risk of hepatitis virus (HV) infections in patients with end-stage kidney disease (ESKD) treated with hemodialysis (HD) is dependent on the HV infection epidemiology in the general population of the area, the need for frequent hospital …

  5. Open Access 01-12-2023 | Antiviral Agents | OriginalPaper

    The care cascade for hepatitis C virus and prognosis of chronic hepatitis C patients treated with antiviral agents in a tertiary hospital

    The current prevalence of chronic hepatitis C in Korea is estimated to be approximately 0.6 to 0.8% [ 1 ]. Among Korean patients afflicted with hepatitis C, genotype 1b and 2 are the most common types [ 1 ]. Overall sustained virologic response …

  6. 01-06-2021 | Dasabuvir | Report

    Levels of tacrolimus after treatment for chronic hepatitis C with direct antiviral agents in solid organ transplant recipients

    Background and objective The main objective was to evaluate the impact of Hepatitis C Virus treatment with direct-acting antiviral agents on tacrolimus blood levels in recipients of kidney and heart allografts. Method We analysed Hepatitis C Virus …

  7. Open Access 01-12-2022 | Liver Transplantation | OriginalPaper

    Clinical outcomes after treatment with direct antiviral agents: beyond the virological response in patients with previous HCV-related decompensated cirrhosis

    The 2000s were marked by an increase in the prevalence of cirrhosis and hepatocellular carcinoma (HCC), mainly due to hepatitis C virus (HCV) infection: 48% of cirrhosis deaths and 67% of HCC deaths in 2013 [ 1 ]. At the same time, HCV infection …

  8. 01-12-2019 | Antiviral Agents | OriginalPaper

    Efficacy and safety of the new antiviral agents for the treatment of hepatitis C virus infection in Egyptian renal transplant recipients

    Chronic hepatitis C virus (HCV) infection can cause liver cirrhosis, liver failure, and hepatocellular carcinoma [ 1 ]. HCV infection is a major public health burden in Egypt, where it has the highest prevalence worldwide (18–20% of the population) …

  9. Open Access 01-12-2019 | Antiviral Agents | OriginalPaper

    Long-term follow-up of HCV infected kidney transplant recipients receiving direct-acting antiviral agents: a single-center experience in China

    Antiviral treatment with DAAs in HCV-infected kidney transplant recipients is persistently effective and well tolerated during long-term follow-up. A regular monitoring of renal function in patients who receive DAAs regimens with preexisting …

  10. 01-02-2022 | Ticagrelor | OriginalPaper

    Potential antiviral properties of antiplatelet agents against SARS-CoV-2 infection: an in silico perspective

    SARS-CoV-2 represents the causative agent of the current pandemic (COVID-19). The drug repurposing technique is used to search for possible drugs that can bind to SARS-CoV-2 proteins and inhibit viral replication. In this study, the FDA-approved …

  11. Open Access 01-12-2021 | Antiviral Agents | OriginalPaper

    Hepatitis C in healthcare personnel: follow-up analysis of treatments with direct-acting antiviral agents

    Viral hepatitis C (HCV) is one of the most prevalent blood-borne infectious diseases in the world and is often chronic. According to estimates of the World Health Organisation (WHO), around 1% of the world’s population carries a chronic hepatitis …

  12. 01-02-2021 | Pravastatin | OriginalPaper

    Evaluation of Pharmacokinetic Drug Interactions of the Direct-Acting Antiviral Agents Elbasvir and Grazoprevir with Pitavastatin, Rosuvastatin, Pravastatin, and Atorvastatin in Healthy Adults

    The introduction of direct-acting antiviral agents has revolutionized the treatment of hepatitis C virus (HCV) infection and offered the possibility of a sustained virologic response to the estimated 71 million people infected with HCV worldwide [ …

  13. 01-10-2019 | Antiviral Agents | News

    Direct antiviral agents

    Hepatitis-B virus reactivation: 2 case reports
  14. Open Access 01-11-2020 | Antiviral Agents | ReviewPaper

    Drug–Drug Interactions between Direct Oral Anticoagulants and Hepatitis C Direct-Acting Antiviral Agents: Looking for Evidence Through a Systematic Review

    In recent years, the direct oral anticoagulants (DOACs) apixaban, dabigatran, edoxaban, and rivaroxaban have been progressively introduced worldwide. By virtue of their favorable pharmacological properties, including predictable pharmacokinetics [ …

  15. 01-04-2020 | Liver Transplantation | OriginalPaper

    Hepatocellular metastasis recurrence in liver transplant after treatment with direct antiviral agents

    Chronic HCV liver infection is considered one of the main causes of liver cirrhosis and hepatocellular carcinoma (HCC). For a selected group of patients, orthotopic liver transplantation (OLTx) is the most effective option to cure both liver …

  16. Open Access 01-10-2020 | Chloroquin | ReviewPaper

    Pharmacokinetics/Pharmacodynamics of Antiviral Agents Used to Treat SARS-CoV-2 and Their Potential Interaction with Drugs and Other Supportive Measures: A Comprehensive Review by the PK/PD of Anti-Infectives Study Group of the European Society of Antimicrobial Agents

    There is an urgent need to identify optimal antiviral therapies for COVID-19 caused by SARS-CoV-2. We have conducted a rapid and comprehensive review of relevant pharmacological evidence, focusing on (1) the pharmacokinetics (PK) of potential …

  17. 01-02-2019 | Antiviral Agents | News

    Direct-acting antiviral agents

    Hepatocellular carcinoma: 2 case reports
  18. Open Access 01-12-2019 | Antiviral Agents | OriginalPaper

    Recurrent hyperkalemia in patients with chronic kidney disease and hepatitis C treated with direct antiviral agents

    Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma. Patients with chronic kidney disease (CKD), especially those with end-stage renal disease (ESRD) on hemodialysis, present high …

  19. 01-11-2019 | Antiviral Agents | OriginalPaper

    Risk of Hepatocellular Cancer Recurrence in Hepatitis C Virus+ Patients Treated with Direct-Acting Antiviral Agents

    Hepatocellular carcinoma (HCC) continues to be the fastest growing cause of cancer-related deaths in the USA [ 1 – 4 ] with chronic infection with hepatitis C virus (HCV) as the most common underlying risk factor. With the advent of highly …

  20. 01-12-2019 | Vasculitis | ReviewPaper

    Clinical outcome of HCV-associated cryoglobulinemic glomerulonephritis following treatment with direct acting antiviral agents: a case-based review

    Newer treatment protocols involving direct-acting antiviral agents (DAAs) have been associated with high rates of sustained virologic response (SVR) and clinical remission in patients with hepatitis C virus (HCV) associated cryoglobulinemic …

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