Gout is a common metabolic disorder affecting the joint and soft tissues, as a result of increased uric acid causing depositions of monosodium urate crystals [ 1 ]. In patients with gout, long term tophus formation and joint flares may progress to …

Diabetic foot ulcer (DFU) is a prevalent complication of diabetes, which is an important factor leading to disability and death of diabetes patients. It is reported that 19–34% of diabetes may be affected by DFU in their lifetime [ 1 ]. Patients …

Resistance remains the major clinical challenge for the therapy of Philadelphia chromosome–positive (Ph+) leukemia. With the exception of ponatinib, all approved tyrosine kinase inhibitors (TKIs) are unable to inhibit the common “gatekeeper” …

Approximately 40% of patients with type 2 diabetes develop diabetic kidney disease (DKD) [ 1 ], a progressive condition that represents the leading cause of end-stage kidney disease (ESKD) [ 1 ]. Furthermore, DKD has been shown to be associated …

Due to the continuous development of oral care and strategies and preventative measures, the frequency of caries and periodontitis has decreased over the past several decades. Consequently, the number of people suffering from total edentulism is …

Breast cancer remains one of the four major cancers, and is expected to account for approximately 30% of all new cancer diagnoses in women in the USA, making it the leading cause of cancer-related deaths in women aged 20–59 years [ 1 ].

Introduction of tyrosine kinase inhibitors (TKIs) has revolutionized the treatment of chronic myeloid leukemia (CML) [ 1 – 3 ], but resistance to TKIs remains a challenge. The BCR-ABL1 T315I “gatekeeper” (the most common kinase domain) mutation …

The original article [ 1 ] contained three erroneous citations and other minor typesetting errors in the text which have since been amended.

Chronic myeloid leukemia (CML) is a myeloproliferative disorder involving the hematopoietic stem cell compartment that is hallmarked by a typical reciprocal translocation between chromosomes 9 and 22. The formed bcr-abl fusion gene is translated …

Desmoid tumors (DTs) or aggressive fibromatoses are rare, with a yearly incidence of 2–5 per 1 million population. Not apt to metastasize, they represent locally infiltrating soft tissue tumors that may occur anywhere in the body [ 1 ]. A seemingly …

An amendment to this paper has been published and can be accessed via the original article.

Advances in neonatology have significantly reduced mortality rates due to prematurity. However, complications of prematurity have barely changed in recent decades. Germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most severe …