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BMC Pulmonary Medicine

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Open Access 01-12-2024 | Sleep Apnea | Research

The association between adipokines and pulmonary diseases: a mendelian randomization study

Authors: Dongcai Wu, Ziyuan Wang, Keju Wang, Yuhan Wang, Tan Wang

Published in: BMC Pulmonary Medicine | Issue 1/2024

Abstract

Background

The role of adipokines in the development of lung diseases is significant, yet their specific relationship with different lung diseases remains unclear.

Methods

In our research, we analyzed genetic variations associated with adipokines and various lung conditions such as interstitial lung disease, chronic obstructive pulmonary disease, asthma, lung cancer, sleep apnea, pneumonia, and tuberculosis, using data from public genome-wide studies. We employed Mendelian randomization techniques, including inverse variance weighting, weighted median, and MR-Egger regression methods, and conducted sensitivity checks to validate our findings.

Results

A study using the FinnGen database, which included 198,955 participants, identified 13 SNPs associated with adiponectin. Notably, adiponectin was found to significantly reduce the risk of interstitial lung disease and idiopathic pulmonary fibrosis. However, little evidence was found to establish a direct cause-effect relationship between the six adipokines and several other lung conditions, including sarcoidosis, asthma, chronic obstructive pulmonary disease, lung cancer, tuberculosis, pneumonia, and sleep apnea syndrome.

Conclusion

This study reveals a reverse link between adiponectin levels and the likelihood of interstitial lung disease, including idiopathic pulmonary fibrosis.

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Title: The association between adipokines and pulmonary diseases: a mendelian randomization study
Authors: Dongcai Wu
Ziyuan Wang
Keju Wang
Yuhan Wang
Tan Wang
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Sleep Apnea
Tuberculosis
Tuberculosis
Idiopathic Pulmonary Fibrosis
Bronchial Asthma
Sarcoidosis
Sarcoidosis
Lung Cancer
Lung Cancer
Lung Cancer
Pneumonia
Published in: BMC Pulmonary Medicine / Issue 1/2024
Electronic ISSN: 1471-2466
DOI: https://doi.org/10.1186/s12890-024-02863-8

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