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Published in: Journal of Experimental & Clinical Cancer Research 1/2021

01-12-2021 | Radiotherapy | Review

Interfering with Tumor Hypoxia for Radiotherapy Optimization

Authors: Irma Telarovic, Roland H. Wenger, Martin Pruschy

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2021

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Abstract

Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical outcome. The significance of hypoxia in the development of resistance to radiotherapy has been recognized for decades and the search for hypoxia-targeting, radiosensitizing agents continues. This review summarizes the main hypoxia-related processes relevant for radiotherapy on the subcellular, cellular and tissue level and discusses the significance of hypoxia in radiation oncology, especially with regard to the current shift towards hypofractionated treatment regimens. Furthermore, we discuss the strategies to interfere with hypoxia for radiotherapy optimization, and we highlight novel insights into the molecular pathways involved in hypoxia that might be utilized to increase the efficacy of radiotherapy.
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Metadata
Title
Interfering with Tumor Hypoxia for Radiotherapy Optimization
Authors
Irma Telarovic
Roland H. Wenger
Martin Pruschy
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
Radiotherapy
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2021
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-021-02000-x

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