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Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2018

Open Access 01-12-2018 | Review

Role of metabolism in cancer cell radioresistance and radiosensitization methods

Authors: Le Tang, Fang Wei, Yingfen Wu, Yi He, Lei Shi, Fang Xiong, Zhaojian Gong, Can Guo, Xiayu Li, Hao Deng, Ke Cao, Ming Zhou, Bo Xiang, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2018

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Abstract

Background

Radioresistance is a major factor leading to the failure of radiotherapy and poor prognosis in tumor patients. Following the application of radiotherapy, the activity of various metabolic pathways considerably changes, which may result in the development of resistance to radiation.

Main body

Here, we discussed the relationships between radioresistance and mitochondrial and glucose metabolic pathways, aiming to elucidate the interplay between the tumor cell metabolism and radiotherapy resistance. In this review, we additionally summarized the potential therapeutic targets in the metabolic pathways.

Short conclusion

The aim of this review was to provide a theoretical basis and relevant references, which may lead to the improvement of the sensitivity of radiotherapy and prolong the survival of cancer patients.
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Metadata
Title
Role of metabolism in cancer cell radioresistance and radiosensitization methods
Authors
Le Tang
Fang Wei
Yingfen Wu
Yi He
Lei Shi
Fang Xiong
Zhaojian Gong
Can Guo
Xiayu Li
Hao Deng
Ke Cao
Ming Zhou
Bo Xiang
Xiaoling Li
Yong Li
Guiyuan Li
Wei Xiong
Zhaoyang Zeng
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2018
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-018-0758-7

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