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Radiation Oncology
Published in: Radiation Oncology 1/2015

Open Access 01-12-2015 | Research

Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all

Authors: Arlene L. Oei, Lianne E. M. Vriend, Johannes Crezee, Nicolaas A. P. Franken, Przemek M. Krawczyk

Published in: Radiation Oncology | Issue 1/2015

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Abstract

The currently available arsenal of anticancer modalities includes many DNA damaging agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both healthy and cancer cells against the effects of treatment and contribute to the development of drug resistance. Therefore, anti-cancer treatments based on inflicting DNA damage can benefit from inhibition of DNA repair. Hyperthermia – treatment at elevated temperature – considerably affects DNA repair, among other cellular processes, and can thus sensitize (cancer) cells to DNA damaging agents. This effect has been known and clinically applied for many decades, but how heat inhibits DNA repair and which pathways are targeted has not been fully elucidated. In this review we attempt to summarize the known effects of hyperthermia on DNA repair pathways relevant in clinical treatment of cancer. Furthermore, we outline the relationships between the effects of heat on DNA repair and sensitization of cells to various DNA damaging agents.
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Metadata
Title
Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all
Authors
Arlene L. Oei
Lianne E. M. Vriend
Johannes Crezee
Nicolaas A. P. Franken
Przemek M. Krawczyk
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2015
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-015-0462-0

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