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Archives of Orthopaedic and Trauma Surgery

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Open Access 24-04-2023 | Radial Nerve Palsy | Trauma Surgery

Humeral shaft fracture: systematic review of non-operative and operative treatment

Authors: Saskia H. Van Bergen, Kiran C. Mahabier, Esther M. M. Van Lieshout, Tim Van der Torre, Cornelia A. W. Notenboom, Priscilla A. Jawahier, Michael H. J. Verhofstad, Dennis Den Hartog

Published in: Archives of Orthopaedic and Trauma Surgery | Issue 8/2023

Abstract

Introduction

Humeral shaft fractures can be treated non-operatively or operatively. The optimal management is subject to debate. The aim was to compare non-operative and operative treatment of a humeral shaft fracture in terms of fracture healing, complications, and functional outcome.

Methods

Databases of Embase, Medline ALL, Web-of-Science Core Collection, and the Cochrane Central Register of Controlled Trials (CENTRAL) were systematically searched for publications reporting clinical and functional outcomes of humeral shaft fractures after non-operative treatment with a functional brace or operative treatment by intramedullary nailing (IMN; antegrade or retrograde) or plate osteosynthesis (open plating or minimally invasive). A pooled analysis of the results was performed using MedCalc.

Results

A total of 173 studies, describing 11,868 patients, were included. The fracture healing rate for the non-operative group was 89% (95% confidence interval (CI) 84–92%), 94% (95% CI 92–95%) for the IMN group and 96% (95% CI 95–97%) for the plating group. The rate of secondary radial nerve palsies was 1% in patients treated non-operatively, 3% in the IMN, and 6% in the plating group. Intraoperative complications and implant failures occurred more frequently in the IMN group than in the plating group. The DASH score was the lowest (7/100; 95% CI 1–13) in the minimally invasive plate osteosynthesis group. The Constant–Murley and UCLA shoulder score were the highest [93/100 (95% CI 92–95) and 33/35 (95% CI 32–33), respectively] in the plating group.

Conclusion

This study suggests that even though all treatment modalities result in satisfactory outcomes, operative treatment is associated with the most favorable results. Disregarding secondary radial nerve palsy, specifically plate osteosynthesis seems to result in the highest fracture healing rates, least complications, and best functional outcomes compared with the other treatment modalities.

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Sarmiento A, Zagorski JB, Zych GA, Latta LL, Capps CA (2000) Functional bracing for the treatment of fractures of the humeral diaphysis. J Bone Jt Surg Am 82:478–486CrossRef

Papasoulis E, Drosos GI, Ververidis AN, Verettas DA (2010) Functional bracing of humeral shaft fractures. A review of clinical studies. Injury 41:e21-27. https://doi.org/10.1016/j.injury.2009.05.004CrossRefPubMed

Rosenberg N, Soudry M (2006) Shoulder impairment following treatment of diaphysial fractures of humerus by functional brace. Arch Orthop Trauma Surg 126:437–440. https://doi.org/10.1007/s00402-006-0167-9CrossRefPubMed

Walker M, Palumbo B, Badman B, Brooks J, Van Gelderen J, Mighell M (2011) Humeral shaft fractures: a review. J Shoulder Elbow Surg 20:833–844. https://doi.org/10.1016/j.jse.2010.11.030CrossRefPubMed

Baltov A, Mihail R, Dian E (2014) Complications after interlocking intramedullary nailing of humeral shaft fractures. Injury 45(Suppl 1):S9–S15. https://doi.org/10.1016/j.injury.2013.10.044CrossRefPubMed

Changulani M, Jain UK, Keswani T (2007) Comparison of the use of the humerus intramedullary nail and dynamic compression plate for the management of diaphyseal fractures of the humerus. A randomised controlled study. Int Orthop 31:391–395. https://doi.org/10.1007/s00264-006-0200-1CrossRefPubMed

Li Y, Wang C, Wang M, Huang L, Huang Q (2011) Postoperative malrotation of humeral shaft fracture after plating compared with intramedullary nailing. J Shoulder Elbow Surg 20:947–954. https://doi.org/10.12659/msm.924400CrossRefPubMed

Van de Wall BJM, Ochen Y, Beeres FJP et al (2020) Conservative vs operative treatment for humeral shaft fractures: a meta-analysis and systematic review of randomized clinical trials and observation studies. J Shoulder Elbow Surg 29(7):1493–1504. https://doi.org/10.1016/j.jse.2020.01.072CrossRefPubMed

Zhao JG, Wang J, Meng XH, Zeng XT, Kan SL (2017) Surgical interventions to treat humerus shaft fractures: a network meta-analysis of randomized controlled trials. PLoS ONE 12:e0173634. https://doi.org/10.1371/journal.pone.0173634CrossRefPubMedPubMedCentral

10.

An Z, Zeng B, He X, Chen Q, Hu S (2010) Plating osteosynthesis of mid-distal humeral shaft fractures: minimally invasive versus conventional open reduction technique. Int Orthop 34:131–135. https://doi.org/10.1007/s00264-009-0753-xCrossRefPubMed

11.

Chen Y, Qiang M, Zhang K, Li H, Dai H (2015) Novel computer-assisted preoperative planning system for humeral shaft fractures: report of 43 cases. Int J Med Robot 11:109–119. https://doi.org/10.1002/rcs.1604CrossRefPubMed

12.

Huttunen TT, Kannus P, Lepola V, Pihlajamaki H, Mattila VM (2012) Surgical treatment of humeral-shaft fractures: a register-based study in Finland between 1987 and 2009. Injury 43:1704–1708. https://doi.org/10.1016/j.injury.2012.06.011CrossRefPubMed

13.

Mahabier KC, Vogels LMM, Punt BJ, Roukema GR, Patka P, Van Lieshout EMM (2013) Humeral shaft fractures: retrospective results of non-operative and operative treatment of 186 patients. Injury 44:427–430. https://doi.org/10.1016/j.injury.2012.08.003CrossRefPubMed

14.

Schoch BS, Padegimas EM, Maltenfort M, Krieg J, Namdari S (2017) Humeral shaft fractures: national trends in management. J Orthop Traumatol 18:259–263. https://doi.org/10.1007/s10195-017-0459-6CrossRefPubMedPubMedCentral

15.

Steffner RJ, Lee MA (2013) Emerging concepts in upper extremity trauma: humeral shaft fractures. Orthop Clin N Am 44:21–33. https://doi.org/10.1016/j.ocl.2012.08.005CrossRef

16.

Beeres FJP, van Veelen N, Houwert RM et al (2022) Open plate fixation versus nailing for humeral shaft fractures: a meta-analysis and systematic review of randomised clinical trials and observational studies. Eur J Trauma Emerg Surg 48(4):2667–2682. https://doi.org/10.1007/s00068-021-01728-7CrossRefPubMed

17.

Heineman DJ, Bhandari M, Poolman RW (2012) Plate fixation or intramedullary fixation of humeral shaft fractures—an update. Acta Orthop 83:317–318. https://doi.org/10.3109/17453674.2012.695677CrossRefPubMedPubMedCentral

18.

Hohmann E, Glatt V, Tetsworth K (2016) Minimally invasive plating versus either open reduction and plate fixation or intramedullary nailing of humeral shaft fractures: a systematic review and meta-analysis of randomized controlled trials. J Shoulder Elbow Surg 25:1634–1642. https://doi.org/10.1016/j.jse.2016.05.014CrossRefPubMed

19.

Keshav K, Baghel A, Kumar V, Neradi D, Kaustubh K, Mishra P (2021) Is minimally invasive plating osteosynthesis better than conventional open plating for humeral shaft fractures? A systematic review and meta-analysis of comparative studies. Indian J Orthop 55(Suppl 2):283–303. https://doi.org/10.1007/s43465-021-00413-6CrossRefPubMedPubMedCentral

20.

Ouyang H, Xiong J, Xiang P, Cui Z, Chen L, Yu B (2013) Plate versus intramedullary nail fixation in the treatment of humeral shaft fractures: an updated meta-analysis. J Shoulder Elbow Surg 22:387–395. https://doi.org/10.1016/j.jse.2012.06.007CrossRefPubMed

21.

Qiu H, Wei Z, Liu Y, Dong J, Zhou X, Yin L et al (2016) A Bayesian network meta-analysis of three different surgical procedures for the treatment of humeral shaft fractures. Medicine (Baltimore) 95:e5464. https://doi.org/10.1097/MD.0000000000005464CrossRefPubMed

22.

Rommens PM, Kuechle R, Bord T, Lewens T, Engelmann R, Blum J (2008) Humeral nailing revisited. Injury 39:1319–1328. https://doi.org/10.1016/j.injury.2008.01.014CrossRefPubMed

23.

Clement ND (2015) Management of humeral shaft fractures; non-operative versus operative. Arch Trauma Res 4:e28013. https://doi.org/10.5812/atr.28013v2CrossRefPubMedPubMedCentral

24.

Lode I, Nordviste V, Erichsen JL, Schmal H, Viberg B (2020) Operative versus nonoperative treatment of humeral shaft fractures: a systematic review and meta-analysis. J Shoulder Elbow Surg 29(12):2495–2504. https://doi.org/10.1016/j.jse.2020.05.030CrossRefPubMed

25.

Sargeant HW, Farrow L, Barker S, Kumar K (2020) Operative versus non-operative treatment of humeral shaft fractures: a systematic review. Shoulder Elbow 12(4):229–242. https://doi.org/10.1177/1758573218825477CrossRefPubMed

26.

Wang X, Chen Z, Shao Y, Ma Y, Fu D, Xia Q (2013) A meta-analysis of plate fixation versus intramedullary nailing for humeral shaft fractures. J Orthop Sci 18:388–397. https://doi.org/10.1007/s00776-013-0355-8CrossRefPubMed

27.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 6:e1000100. https://doi.org/10.1371/journal.pmed.1000100CrossRefPubMedPubMedCentral

28.

Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y, Chipponi J (2003) Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg 73:712–716. https://doi.org/10.1046/j.1445-2197.2003.02748.xCrossRefPubMed

29.

Barendregt JJ, Doi SA, Lee YY, Norman RE, Vos T (2013) Meta-analysis of prevalence. J Epidemiol Community Health 67:974–978. https://doi.org/10.1136/jech-2013-203104CrossRefPubMed

30.

Chapman JR, Henley MB, Agel J, Benca PJ (2000) Randomized prospective study of humeral shaft fracture fixation: intramedullary nails versus plates. J Orthop Trauma 14:162–166CrossRefPubMed

31.

McCormack RG, Brien D, Buckley RE, McKee MD, Powell J, Schemitsch EH (2000) Fixation of fractures of the shaft of the humerus by dynamic compression plate or intramedullary nail. A prospective, randomised trial. J Bone Jt Surg Br 82:336–339CrossRef

32.

Paris H, Tropiano P, Clouet D’orval B, Chaudet H, Poitout DG (2000) [Fractures of the shaft of the humerus: systematic plate fixation. Anatomic and functional results in 156 cases and a review of the literature] Fractures diaphysaires de l’humerus : osteosynthese systematique par plaque. Resultats anatomiques et fonctionnels d’une serie de 156 cas et revue de la litterature]. Rev Chir Orthop Reparatrice Appar Mot 86:346–359PubMed

33.

Tingstad EM, Wolinsky PR, Shyr Y, Johnson KD (2000) Effect of immediate weightbearing on plated fractures of the humeral shaft. J Trauma 49:278–280. https://doi.org/10.1097/00005373-200008000-00014CrossRefPubMed

34.

Blum J, Janzing H, Gahr R, Langendorff HS, Rommens PM (2001) Clinical performance of a new medullary humeral nail: antegrade versus retrograde insertion. J Orthop Trauma 15:342–349. https://doi.org/10.1097/00005131-200106000-0007CrossRefPubMed

35.

Koch PP, Gross DF, Gerber C (2002) The results of functional (Sarmiento) bracing of humeral shaft fractures. J Shoulder Elbow Surg 11:143–150. https://doi.org/10.1067/mse.2002.121634CrossRefPubMed

36.

Chaker A, Filipinsky J (2003) [Sport-related spiral fractures of the humeral diaphysis are not simple injuries] Sportovni spiralni zlomeniny diafyzy humeru nejsou jednoduchym poranenim. Rozhl Chir 82(235–238):44

37.

Kesemenli CC, Subasi M, Arslan H, Necmioglu S, Kapukaya A (2003) [Comparison between the results of intramedullary nailing and compression plate fixation in the treatment of humerus fractures] Humerus kirikli olgularda kilitli intrameduller civi ve plak ile tedavi sonuclarinin karsilastirilmasi. Acta Orthop Traumatol Turc 37:120–125PubMed

38.

Ni JD, Tan J (2003) Dong ZG [Treatment of humeral shaft fractures with Russell–Taylor interlocking intramedullar nail]. Hunan Yi Ke Da Xue Xue Bao 28:159–161PubMed

39.

Fernandez FF, Matschke S, Hulsenbeck A, Egenolf M, Wentzensen A (2004) Five years’ clinical experience with the unreamed humeral nail in the treatment of humeral shaft fractures. Injury 35:264–271. https://doi.org/10.1016/s0020-1383(03)00220-1CrossRefPubMed

40.

Flinkkila T, Hyvonen P, Siira P, Hamalainen M (2004) Recovery of shoulder joint function after humeral shaft fracture: a comparative study between antegrade intramedullary nailing and plate fixation. Arch Orthop Trauma Surg 124:537–541. https://doi.org/10.1007/s00402-004-0727-9CrossRefPubMed

41.

Livani B, Belangero WD (2004) Bridging plate osteosynthesis of humeral shaft fractures. Injury 35:587–595. https://doi.org/10.1016/j.injury.2003.12.003CrossRefPubMed

42.

Niall DM, O’Mahony J, McElwain JP (2004) Plating of humeral shaft fractures–has the pendulum swung back? Injury 35:580–586. https://doi.org/10.1016/j.injury.2003.10.021CrossRefPubMed

43.

Chao TC, Chou WY, Chung JC, Hsu CJ (2005) Humeral shaft fractures treated by dynamic compression plates, Ender nails and interlocking nails. Int Orthop 29:88–91. https://doi.org/10.1007/s00264-004-0620-8CrossRefPubMedPubMedCentral

44.

Kirdemir V, Sehirlioglu A, Baykal B, Bek D, Demiralp B (2005) The results for the treatment of humeral shaft fractures using functional bracing. Gulhane Med J 47:40–43

45.

Toivanen JA, Nieminen J, Laine HJ, Honkonen SE, Jarvinen MJ (2005) Functional treatment of closed humeral shaft fractures. Int Orthop 29:10–13. https://doi.org/10.1007/s00264-004-0612-8CrossRefPubMed

46.

Apard T, Lahogue JF, Prove S, Hubert L, Talha A, Cronier P et al (2006) [Retrograde locked nailing of humeral shaft fractures: a prospective study of 58 cases] Traitement des fractures recentes de la diaphyse humerale par enclouage centromedullaire verrouille retrograde: une etude prospective de 58 cas. Rev Chir Orthop Reparatrice Appar Mot 92:19–26CrossRefPubMed

47.

Ekholm R, Tidermark J, Tornkvist H, Adami J, Ponzer S (2006) Outcome after closed functional treatment of humeral shaft fractures. J Orthop Trauma 20:591–596. https://doi.org/10.1097/01.bot.0000246466.01287.04CrossRefPubMed

48.

Hernandez C, Villanueva M, Juarez J, Torres M, Esparragoza L, Benito F (2006) Technical complications of Seidel’s nailing of the humerus. Rev Ortop Traumatol 50:342–353

49.

Jawa A, McCarty P, Doornberg J, Harris M, Ring D (2006) Extra-articular distal-third diaphyseal fractures of the humerus. A comparison of functional bracing and plate fixation. J Bone Jt Surg Am 88:2343–2347. https://doi.org/10.2106/JBJS.F.00334CrossRef

50.

Martinez-Diaz S, Ramirez M, Marques F, Gines A, Monllau JC, Martinez-Gomez X et al (2006) Fracturas diafisarias de húmero en mayores de 60 años: enclavado intramedular rigido [Rigid intramedullary nailing of humeral shaft fractures in patients older than 60]. Rev Ortop Traumatol 50:8–13. https://doi.org/10.1016/S0482-5985(06)74927-6CrossRef

51.

Pospula W, Abu NT (2006) Percutaneous fixation of comminuted fractures of the humerus: initial experience at Al Razi hospital Kuwait. Med Princ Pract 15:423–426. https://doi.org/10.1159/000095487CrossRefPubMed

52.

Rochet S, Obert L, Sarlieve P, Clappaz P, Lepage D, Garbuio P et al (2006) [Functional and sonographic shoulder assessment after Seidel nailing: a retrospective of 29 cases] Evaluation fonctionnelle et echographique de l’epaule apres enclouage de Seidel. Rev Chir Orthop Reparatrice Appar Mot 92:549–555CrossRefPubMed

53.

Rutgers M, Ring D (2006) Treatment of diaphyseal fractures of the humerus using a functional brace. J Orthop Trauma 20:597–601. https://doi.org/10.1097/01.bot.0000249423.48074.82CrossRefPubMed

54.

Cuny C, Irrazi M, Ionescu N, Locquet V, Chaumont PL, Berrichi A et al (2007) [The long Telegraph nail for humeral fractures] Le clou Telegraph long dans les fractures de l’humerus. Rev Chir Orthop Reparatrice Appar Mot 93:564–570CrossRefPubMed

55.

Jiang R, Luo CF, Zeng BF, Mei GH (2007) Minimally invasive plating for complex humeral shaft fractures. Arch Orthop Trauma Surg 127:531–535. https://doi.org/10.1007/s00402-007-0313-zCrossRefPubMed

56.

Numbela BX, Aceves LH, Gonzalez AB, Castro CT (2007) [Minimally invasive surgery in diaphyseal humeral fractures with helicoidal plate. One year result in seven patients] Placa helicoidal aplicada en fracturas diafisarias de humero por cirugia de minima invasion (MIS). Resultados de un ano de seguimiento en 7 casos. Acta Ortop Mex 21:239–246PubMed

57.

Ozkurt B, Altay M, Aktekin CN, Toprak A, Tabak Y (2007) [The role of functional bracing in the treatment of humeral shaft fractures] Humerus cisim kiriklarinda fonksiyonel breys tedavisinin yeri. Acta Orthop Traumatol Turc 41:15–20PubMed

58.

Raghavendra S, Bhalodiya HP (2007) Internal fixation of fractures of the shaft of the humerus by dynamic compression plate or intramedullary nail: a prospective study. Indian J Orthop 41:214–218. https://doi.org/10.4103/0019-5413.33685CrossRefPubMedPubMedCentral

59.

Zhiquan A, Bingfang Z, Yeming W, Chi Z, Peiyan H (2007) Minimally invasive plating osteosynthesis (MIPO) of middle and distal third humeral shaft fractures. J Orthop Trauma 21:628–633. https://doi.org/10.1097/BOT.0b013e31815928c2CrossRefPubMed

60.

Cheng HR, Lin J (2008) Prospective randomized comparative study of antegrade and retrograde locked nailing for middle humeral shaft fracture. J Trauma 65:94–102. https://doi.org/10.1097/TA.0b013e31812eed7fCrossRefPubMed

61.

Ekholm R, Ponzer S, Tornkvist H, Adami J, Tidermark J (2008) The Holstein–Lewis humeral shaft fracture: aspects of radial nerve injury, primary treatment, and outcome. J Orthop Trauma 22:693–697. https://doi.org/10.1097/BOT.0b013e31818915bfCrossRefPubMed

62.

Muckley T, Diefenbeck M, Sorkin AT, Beimel C, Goebel M, Buhren V (2008) Results of the T2 humeral nailing system with special focus on compression interlocking. Injury 39:299–305. https://doi.org/10.1016/j.injury.2007.08.031CrossRefPubMed

63.

An Z, He X, Zeng B (2009) A comparative study on open reduction and plating osteosynthesis and minimal invasive plating osteosynthesis in treating mid-distal humeral shaft fractures. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:41–44PubMed

64.

Apivatthakakul T, Phornphutkul C, Laohapoonrungsee A, Sirirungruangsarn Y (2009) Less invasive plate osteosynthesis in humeral shaft fractures. Oper Orthop Traumatol 21:602–613. https://doi.org/10.1007/s00064-009-2008-9CrossRefPubMed

65.

Ji F, Tong D, Tang H, Cai X, Zhang Q, Li J et al (2009) Minimally invasive percutaneous plate osteosynthesis (MIPPO) technique applied in the treatment of humeral shaft distal fractures through a lateral approach. Int Orthop 33:543–547. https://doi.org/10.1007/s00264-008-0522-2CrossRefPubMed

66.

Li WY, Zhang BS, Zhang L, Zheng SH, Wang S (2009) Comparative study of antegrade and retrograde intramedullary nailing for the treatment of humeral shaft fractures. Zhongguo Gu Shang 22:199–201PubMed

67.

Putti AB, Uppin RB, Putti BB (2009) Locked intramedullary nailing versus dynamic compression plating for humeral shaft fractures. J Orthop Surg (Hong Kong) 17:139–141. https://doi.org/10.1177/230949900901700202CrossRefPubMed

68.

Wang ZH, Xiang M, Xie J, Tang HC, Chen H, Liu X (2009) Treatment of humerus shaft fractures using minimally invasive percutaneous plate osteosynthesis through anterior approach. Zhongguo Gu Shang 22:681–683PubMed

69.

Concha JM, Sandoval A, Streubel PN (2010) Minimally invasive plate osteosynthesis for humeral shaft fractures: are results reproducible? Int Orthop 34:1297–1305. https://doi.org/10.1007/s00264-009-0893-zCrossRefPubMed

70.

Denard A Jr, Richards JE, Obremskey WT, Tucker MC, Floyd M, Herzog GA (2010) Outcome of nonoperative vs operative treatment of humeral shaft fractures: a retrospective of 213 patients. Orthopedics. https://doi.org/10.3928/01477447-20100625-16CrossRefPubMed

71.

Denies E, Nijs S, Sermon A, Broos P (2010) Operative treatment of humeral shaft fractures. Comparison of plating and intramedullary nailing. Acta Orthop Belg 76:735–742PubMed

72.

Kobayashi M, Watanabe Y, Matsushita T (2010) Early full range of shoulder and elbow motion is possible after minimally invasive plate osteosynthesis for humeral shaft fractures. J Orthop Trauma 24:212–216. https://doi.org/10.1097/BOT.0b013e3181c2fe49CrossRefPubMed

73.

Singisetti K, Ambedkar M (2010) Nailing versus plating in humerus shaft fractures: a prospective comparative study. Int Orthop 34:571–576. https://doi.org/10.1007/s00264-009-0813-2CrossRefPubMed

74.

Yin B, Yang B, Li J, Zhang Z, Zhang L, Song L et al (2010) Antegrade intramedullary nailing versus retrograde intramedullary nailing for humeral shaft fracture in 18 cases. J Clin Rehab Tissue Eng Res 14:4899–4902. https://doi.org/10.3969/j.issn.1673-8225.2010.26.037CrossRef

75.

Ziran BH, Kinney RC, Smith WR, Peacher G (2010) Sub-muscular plating of the humerus: an emerging technique. Injury 41:1047–1052. https://doi.org/10.1016/j.injury.2010.04.021CrossRefPubMed

76.

Algarin-Reyes JA, Bello-Gonzalez A, Perez-Calzadilla M, Flores-Giron J (2011) [Treatment of distal humeral shaft fractures at Polanco Mexican Red Cross] Tratamiento de las fracturas diafisarias del tercio distal de humero en la Cruz Roja Mexicana Polanco. Acta Ortop Mex 25:264–272PubMed

77.

Grass G, Kabir K, Ohse J, Rangger C, Besch L, Mathiak G (2011) Primary exploration of radial nerve is not required for radial nerve palsy while treating humerus shaft fractures with Unreamed Humerus Nails (UHN). Open Orthop J 5:319–323. https://doi.org/10.2174/1874325001105010319CrossRefPubMedPubMedCentral

78.

Kirin I, Jurisic D, Grebic D, Nadalin S (2011) The advantages of humeral anteromedial plate osteosynthesis in the middle third shaft fractures. Wien Klin Wochenschr 123:83–87. https://doi.org/10.1007/s00508-010-1523-xCrossRefPubMed

79.

Li Y, Tian Q, Leng K, Guo M (2020) Comparison of the posterior and anterolateral surgical approaches in the treatment of humeral mid-shaft fractures: a retrospective study. Med Sci Monit. https://doi.org/10.12659/MSM.924400CrossRefPubMedPubMedCentral

80.

Lopez-Arevalo R, de Llano-Temboury AQ, Serrano-Montilla J, de Llano-Gimenez EQ, Fernandez-Medina JM (2011) Treatment of diaphyseal humeral fractures with the minimally invasive percutaneous plate (MIPPO) technique: a cadaveric study and clinical results. J Orthop Trauma 25:294–299. https://doi.org/10.1097/BOT.0b013e3181f98421CrossRefPubMed

81.

Prasarn ML, Ahn J, Paul O, Morris EM, Kalandiak SP, Helfet DL et al (2011) Dual plating for fractures of the distal third of the humeral shaft. J Orthop Trauma 25:57–63. https://doi.org/10.1097/BOT.0b013e3181df96a7CrossRefPubMed

82.

Shetty MS, Kumar MA, Sujay K, Kini AR, Kanthi KG (2011) Minimally invasive plate osteosynthesis for humerus diaphyseal fractures. Indian J Orthop 45:520–526. https://doi.org/10.4103/0019-5413.87123CrossRefPubMedPubMedCentral

83.

Tsourvakas S, Alexandropoulos C, Papachristos I, Tsakoumis G, Ameridis N (2011) Treatment of humeral shaft fractures with antegrade intramedullary locking nail. Musculoskelet Surg 95:193–198. https://doi.org/10.1007/s12306-011-0126-7CrossRefPubMed

84.

Van Middendorp JJ, Kazacsay F, Lichtenhahn P, Renner N, Babst R, Melcher G (2011) Outcomes following operative and non-operative management of humeral midshaft fractures: a prospective, observational cohort study of 47 patients. Eur J Trauma Emerg Surg 37:287–296. https://doi.org/10.1007/s00068-011-0099-0CrossRefPubMedPubMedCentral

85.

Brunner A, Thormann S, Babst R (2012) Minimally invasive percutaneous plating of proximal humeral shaft fractures with the Proximal Humerus Internal Locking System (PHILOS). J Shoulder Elbow Surg 21:1056–1063. https://doi.org/10.1016/j.jse.2011.05.016CrossRefPubMed

86.

Firat A, Deveci A, Guler F, Ocguder A, Oguz T, Bozkurt M (2012) Evaluation of shoulder and elbow functions after treatment of humeral shaft fractures: a 20–132-month follow-up study. Acta Orthop Traumatol Turc 46:229–236. https://doi.org/10.3944/aott.2012.2486CrossRefPubMed

87.

Iacobellis C, Agro T, Aldegheri R (2012) Locked antegrade intramedullary nailing of humeral shaft fractures. Musculoskelet Surg 96:67–73. https://doi.org/10.1007/s12306-011-0166-zCrossRefPubMed

88.

Idoine JD 3rd, French BG, Opalek JM, DeMott L (2012) Plating of acute humeral diaphyseal fractures through an anterior approach in multiple trauma patients. J Orthop Trauma 26:9–18. https://doi.org/10.1097/BOT.0b013e318214ebd5CrossRefPubMed

89.

Kulkarni SG, Varshneya A, Jain M, Kulkarni VS, Kulkarni GS, Kulkarni MG et al (2012) Antegrade interlocking nailing versus dynamic compression plating for humeral shaft fractures. J Orthop Surg (Hong Kong) 20:288–291. https://doi.org/10.1177/230949901202000304CrossRefPubMed

90.

Kumar R, Singh P, Chaudhary LJ, Singh S (2012) Humeral shaft fracture management, a prospective study; nailing or plating. J Clin Orthop Traum 3:37–42. https://doi.org/10.1016/j.jcot.2012.04.003CrossRef

91.

Malhan S, Thomas S, Srivastav S, Agarwal S, Mittal V, Nadkarni B et al (2012) Minimally invasive plate osteosynthesis using a locking compression plate for diaphyseal humeral fractures. J Orthop Surg (Hong Kong) 20:292–296. https://doi.org/10.1177/230949901202000305CrossRefPubMed

92.

Oh CW, Byun YS, Oh JK, Kim JJ, Jeon IH, Lee JH et al (2012) Plating of humeral shaft fractures: comparison of standard conventional plating versus minimally invasive plating. Orthop Traumatol Surg Res 98:54–60. https://doi.org/10.1016/j.otsr.2011.09.016CrossRefPubMed

93.

Pagonis T, Ditsios K, Christodoulou A, Petsatodis G (2012) Outcome of surgical treatment for complicated humeral shaft fractures in elderly adults with osteoporosis. J Am Geriatr Soc 60:795–796. https://doi.org/10.1111/j.1532-5415.2011.03876.xCrossRefPubMed

94.

Shin SJ, Sohn HS, Do NH (2012) Minimally invasive plate osteosynthesis of humeral shaft fractures: a technique to aid fracture reduction and minimize complications. J Orthop Trauma 26:585–589. https://doi.org/10.1097/BOT.0b013e318254895fCrossRefPubMed

95.

Tan JC, Kagda FH, Murphy D, Thambiah JS, Khong KS (2012) Minimally invasive helical plating for shaft of humerus fractures: technique and outcome. Open Orthop J 6:184–188. https://doi.org/10.2174/1874325001206010184CrossRefPubMedPubMedCentral

96.

Yang Q, Wang F, Wang Q, Gao W, Huang J, Wu X et al (2012) Surgical treatment of adult extra-articular distal humeral diaphyseal fractures using an oblique metaphyseal locking compression plate via a posterior approach. Med Princ Pract 21:40–45. https://doi.org/10.11817/j.issn.1672-7347.2014.11.009CrossRefPubMed

97.

Zhou ZB, Gao YS, Tang MJ, Sun YQ, Zhang CQ (2012) Minimally invasive percutaneous osteosynthesis for proximal humeral shaft fractures with the PHILOS through the deltopectoral approach. Int Orthop 36:2341–2345. https://doi.org/10.1007/s00264-012-1649-8CrossRefPubMedPubMedCentral

98.

Aydin BK, Akmese R, Agar M (2013) Humeral shaft fractures secondary to hand grenade throwing. ISRN Orthop 2013:962609. https://doi.org/10.1155/2013/962609CrossRefPubMedPubMedCentral

99.

Biber R, Zirngibl B, Bail HJ, Stedtfeld HW (2013) An innovative technique of rear entry creation for retrograde humeral nailing: how to avoid iatrogenic comminution. Injury 44:514–517. https://doi.org/10.1016/j.injury.2012.12.019CrossRefPubMed

100.

Boschi V, Pogorelic Z, Gulan G, Vilovic K, Stalekar H, Bilan K et al (2013) Subbrachial approach to humeral shaft fractures: new surgical technique and retrospective case series study. Can J Surg 56:27–34. https://doi.org/10.1503/cjs.011911CrossRefPubMedPubMedCentral

101.

Chen F, Wang Z, Bhattacharyya T (2013) Outcomes of nails versus plates for humeral shaft fractures: a Medicare cohort study. J Orthop Trauma 27:68–72. https://doi.org/10.1007/s00264-004-0620-8CrossRefPubMedPubMedCentral

102.

Kapil Mani KC, Gopal Sagar DC, Rijal L, Govinda KC, Shrestha BL (2013) Study on outcome of fracture shaft of the humerus treated non-operatively with a functional brace. Eur J Orthop Surg Traumatol 23:323–328. https://doi.org/10.1007/s00590-012-0982-3CrossRefPubMed

103.

Lee TJ, Kwon DG, Na SI, Cha SD (2013) Modified combined approach for distal humerus shaft fracture: anterolateral and lateral bimodal approach. Clin Orthop Surg 5:209–215. https://doi.org/10.4055/cios.2013.5.3.209CrossRefPubMedPubMedCentral

104.

Lee HJ, Oh CW, Oh JK, Apivatthakakul T, Kim JW, Yoon JP et al (2013) Minimally invasive plate osteosynthesis for humeral shaft fracture: a reproducible technique with the assistance of an external fixator. Arch Orthop Trauma Surg 133:649–657. https://doi.org/10.1007/s00402-013-1708-7CrossRefPubMed

105.

Lian K, Wang L, Lin D, Chen Z (2013) Minimally invasive plating osteosynthesis for mid-distal third humeral shaft fractures. Orthopedics 36:e1025-1032. https://doi.org/10.3928/01477447-20130724-18CrossRefPubMed

106.

Sharaby M, Elhawary A (2012) A simple technique for double plating of extraarticular distal humeral shaft fractures. Acta Orthop Belg 78:708–713PubMed

107.

Shen L, Qin H, An Z, Zeng B, Yang F (2013) Internal fixation of humeral shaft fractures using minimally invasive plating: comparative study of two implants. Eur J Orthop Surg Traumatol 23:527–534. https://doi.org/10.1007/s00590-012-1039-3CrossRefPubMed

108.

Tyllianakis M, Tsoumpos P, Anagnostou K, Konstantopoulou A, Panagopoulos A (2013) Intramedullary nailing of humeral diaphyseal fractures. Is distal locking really necessary? Int J Shoulder Surg 7:65–69. https://doi.org/10.4103/0973-6042.114233CrossRefPubMedPubMedCentral

109.

Verdano MA, Pellegrini A, Schiavi P, Somenzi L, Concari G, Ceccarelli F (2013) Humeral shaft fractures treated with antegrade intramedullary nailing: what are the consequences for the rotator cuff? Int Orthop 37:2001–2007. https://doi.org/10.1007/s00264-013-2007-1CrossRefPubMedPubMedCentral

110.

Wang C, Dai G, Wang S, Liu Q, Liu W (2013) The function and muscle strength recovery of shoulder after humeral diaphysis fracture following plating and intramedullary nailing. Arch Orthop Trauma Surg 133:1089–1094. https://doi.org/10.1007/s00402-013-1768-8CrossRefPubMed

111.

Yi JW, Oh JK, Han SB, Shin SJ, Oh CW, Yoon YC (2013) Healing process after rigid plate fixation of humeral shaft fractures revisited. Arch Orthop Trauma Surg 133:811–817. https://doi.org/10.1007/s00402-013-1727-4CrossRefPubMed

112.

Yin P, Mao Z, Zhang L, Tao S, Zhang Q, Liang X et al (2013) Effectiveness comparison between locking compression plate fixation and locked intramedullary nail fixation for humeral shaft fracture of types B and C. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 27:1457–1461PubMed

113.

Balam KM, Zahrany AS (2014) Posterior percutaneous plating of the humerus. Eur J Orthop Surg Traumatol 24:763–768. https://doi.org/10.1007/s00590-013-1355-2CrossRefPubMed

114.

Benegas E, Ferreira Neto AA, Gracitelli ME, Malavolta EA, Assuncao JH, Prada FD et al (2014) Shoulder function after surgical treatment of displaced fractures of the humeral shaft: a randomized trial comparing antegrade intramedullary nailing with minimally invasive plate osteosynthesis. J Shoulder Elbow Surg. https://doi.org/10.1016/j.jse.2014.02.010CrossRefPubMed

115.

Huri G, Bicer OS, Ozturk H, Deveci MA, Tan I (2014) Functional outcomes of minimal invasive percutaneous plate osteosynthesis (MIPPO) in humerus shaft fractures: a clinical study. Acta Orthop Traumatol Turc 48:406–412. https://doi.org/10.3944/AOTT.2014.13.0009CrossRefPubMed

116.

Neuhaus V, Menendez M, Kurylo JC, Dyer GS, Jawa A, Ring D (2014) Risk factors for fracture mobility six weeks after initiation of brace treatment of mid-diaphyseal humeral fractures. J Bone Jt Surg Am 96:403–407. https://doi.org/10.2106/JBJS.M.00089CrossRef

117.

Radulescu R, Badila A, Nutiu O, Japie I, Terinte S, Radulescu D et al (2014) Osteosynthesis in fractures of the distal third of humeral diaphysis. Maedica (Buchar) 9:44–48

118.

Singh AK, Narsaria N, Seth RR, Garg S (2014) Plate osteosynthesis of fractures of the shaft of the humerus: comparison of limited contact dynamic compression plates and locking compression plates. J Orthop Traumatol. https://doi.org/10.1007/s10195-014-0290-2CrossRefPubMedPubMedCentral

119.

Wali MG, Baba AN, Latoo IA, Bhat NA, Baba OK, Sharma S (2014) Internal fixation of shaft humerus fractures by dynamic compression plate or interlocking intramedullary nail: a prospective, randomised study. Strategies Trauma Limb Reconstr 9:133–140. https://doi.org/10.1007/s11751-014-0204-0CrossRefPubMedPubMedCentral

120.

Wang X, Yin D, Liang B, Qiu D (2014) Anterolateral minimally invasive plate osteosynthesis technique for distal humeral shaft fracture. Zhong Nan Da Xue Xue Bao Yi Xue Ban 39:1157–1162. https://doi.org/10.11817/j.issn.1672-7347.2014.11.009CrossRefPubMed

121.

Yin P, Zhang L, Mao Z, Zhao Y, Zhang Q, Tao S et al (2014) Comparison of lateral and posterior surgical approach in management of extra-articular distal humeral shaft fractures. Injury. https://doi.org/10.1016/j.injury.2014.02.034CrossRefPubMed

122.

Zogaib RK, Morgan S, Belangero PS, Fernandes HJ, Belangero WD, Livani B (2014) Minimal invasive ostheosintesis for treatment of diaphiseal transverse humeral shaft fractures. Acta Ortop Bras 22:94–98. https://doi.org/10.1590/1413-78522014220200698CrossRefPubMedPubMedCentral

123.

Zogbi DR, Terrivel AM, Mouraria GG, Mongon ML, Kikuta FK, Filho AZ (2014) Fracture of distal humerus: MIPO technique with visualization of the radial nerve. Acta Ortop Bras 22:300–303. https://doi.org/10.1590/1413-78522014220601003CrossRefPubMedPubMedCentral

124.

Ali E, Griffiths D, Obi N, Tytherleigh-Strong G, Van Rensburg L (2015) Nonoperative treatment of humeral shaft fractures revisited. J Shoulder Elbow Surg 24:210–214. https://doi.org/10.1016/j.jse.2014.05.009CrossRefPubMed

125.

Campochiaro G, Baudi P, Loschi R, Serafin F, Catani F (2015) Complex fractures of the humeral shaft treated with antegrade locked intramedullary nail: clinical experience and long-term results. Acta Biomed 86:69–76PubMed

126.

Ebrahimpour A, Najafi A, Manafi RA (2015) Outcome assessment of operative treatment of humeral shaft fractures by antegrade Unreamed Humeral Nailing (UHN). Indian J Surg 77:186–190. https://doi.org/10.1007/s12262-012-0756-5CrossRefPubMed

127.

Esmailiejah AA, Abbasian MR, Safdari F, Ashoori K (2015) Treatment of humeral shaft fractures: Minimally invasive plate osteosynthesis versus open reduction and internal fixation. Trauma Mon 20:e26271. https://doi.org/10.5812/traumamon.26271v2CrossRefPubMedPubMedCentral

128.

Fan Y, Li YW, Zhang HB, Liu JF, Han XM, Chang X et al (2015) Management of humeral shaft fractures with intramedullary interlocking nail versus locking compression plate. Orthopedics 38:e825-829. https://doi.org/10.3928/01477447-20150902-62CrossRefPubMed

129.

Feng T (2015) Fixation with intramedullary nail and plate in the treatment of adult humeral shaft fracture: Comparison of radial nerve injury and non-union rate. Chin J Tissue Eng Res 19:2086–2090. https://doi.org/10.3969/j.issn.2095-4344.2015.13.022CrossRef

130.

Gallucci GL, Boretto JG, Alfie VA, Donndorff A, De Carli P (2015) Posterior minimally invasive plate osteosynthesis (MIPO) of distal third humeral shaft fractures with segmental isolation of the radial nerve. Chir Main 34:221–226. https://doi.org/10.1016/j.main.2015.06.007CrossRefPubMed

131.

Hadhoud DA, Mesriga MM (2015) Minimally invasive plate osteosynthesis versus open reduction and plate fixation of humeral shaft fractures. Menoufia Med J 28:154–161. https://doi.org/10.4103/1110-2098.155974CrossRef

132.

Kim SJ, Lee SH, Son H, Lee BG (2015) Surgical result of plate osteosynthesis using a locking plate system through an anterior humeral approach for distal shaft fracture of the humerus that occurred during a throwing motion. Int Orthop. https://doi.org/10.1007/s00264-015-2895-2893CrossRefPubMed

133.

Koca K, Ege T, Kurklu M, Ekinci S, Bilgic S (2015) Spiral-medial butterfly fractures (AO-12-B1) in distal diaphysis of humerus with rotational forces: preliminary results of open reduction and plate-screw fixation. Eur Rev Med Pharmacol Sci 19:4494–4497PubMed

134.

Kumar MN, Ravishankar MR, Manur R (2015) Single locking compression plate fixation of extra-articular distal humeral fractures. J Orthop Traumatol 16:99–104. https://doi.org/10.1007/s10195-014-0325-8CrossRefPubMed

135.

Modi N, Pundkar GN (2015) Comparative study of functional outcome of dynamic compression plating with Intramedullary Interlocking nailing in close fracture shaft of humerus in adults. J Med Dent Sci 3:298–302. https://doi.org/10.5455/jrmds.20153412CrossRef

136.

Patino JM, Ramella JC, Michelini AE, Abdon IM, Rodriguez EF, Corna AFR (2021) Plates vs nails in humeral shaft fractures: do plates lead to a better shoulder function? JSES Int 5:765–768. https://doi.org/10.1016/j.jseint.2021.01.012CrossRefPubMedPubMedCentral

137.

Reddy BJ, Athmaram M, Swaroop VS (2015) A clinical study of fixation of fracture of shaft of humerus with interlocking nail. JEMDS 4:2172–2179. https://doi.org/10.14260/JEMDS/2015/312CrossRef

138.

Sahu RL, Ranjan R, Lal A (2015) Fracture union in closed interlocking nail in humeral shaft fractures. Chin Med J (Engl) 128:1428–1432. https://doi.org/10.4103/0366-6999.157630CrossRefPubMed

139.

Sanjeevaiah RP (2015) Minimally invasive plate osteosynthesis (Mipo) in humeral shaft fractures—biomechanics—design—clinical results. JEMDS 4:9449–9456. https://doi.org/10.14260/jemds/2015/1368CrossRef

140.

Shields E, Sundem L, Childs S, Maceroli M, Humphrey C, Ketz JP et al (2015) The impact of residual angulation on patient reported functional outcome scores after non-operative treatment for humeral shaft fractures. Injury. https://doi.org/10.1016/j.injury.2015.12.014CrossRefPubMed

141.

Singhal R, Stewart P, Panayiotou CC (2015) A pre-fabricated bracing system for the management of humeral shaft fractures: experience of a centre in the United Kingdom. Ortop Traumatol Rehabil 17:463–470. https://doi.org/10.5604/15093492.1186816CrossRefPubMed

142.

Srinivas K, Rajaiah D, Ramana Y, Omkaram S, Reddy SV (2015) A study of surgical management of diaphyseal fractures of humerus by dynamic compression plate osteosynthesis. JEMDS 4:1290–1296CrossRef

143.

Wang C, Li J, Li Y, Dai G, Wang M (2015) Is minimally invasive plating osteosynthesis for humeral shaft fracture advantageous compared with the conventional open technique? J Shoulder Elbow Surg 24:1741–1748. https://doi.org/10.1016/j.jse.2015.07.032CrossRefPubMed

144.

Abril Gaona C, Arroyo CA, David AE, Plata GV (2018) Treatment of distal diaphyseal humeral fractures with minimally invasive posterior approach and anatomical extraarticular plate. Rev Colomb Ortop Traumatol 32:178–183. https://doi.org/10.1016/j.rccot.2017.11.005CrossRef

145.

Anand Kumar BS, Soraganvi P, Satyarup D (2016) Treatment of middle third humeral shaft fractures with anteromedial plate osteosynthesis through an anterolateral approach. Malays Orthop J 10:38–43. https://doi.org/10.5704/moj.1603.007CrossRef

146.

Gang Z, Haonan L, Ning L, Liang H, Xinbao W (2016) Comparison of mid-term surgical results between plate and intramedullary nail for humeral shaft fracture. Nat Med J China 96:2988–2992. https://doi.org/10.3760/cma.j.issn.0376-2491.2016.37.07CrossRef

147.

Guzmán-Guevara J, López-Cázares G, Barragán-Hervella RG, Villegas-Rosas JS, Alvarado-Ortega I, Montiel-Jarquín Á (2016) Evaluation of patients with humeral midshaft fractures treated with DCP plate vs intramedullary nail UHN. Rev Med Inst Mex Seguro Soc 54:S270–S274PubMed

148.

Karunanithi S, Anbu S, Palaniappan M, Kolundan K, Kannan K, Ganesan RP (2016) A study of functional, clinical and radiological outcome of fracture shaft of humerus mid and distal third managed by Mippo technique. JEMDS 5:5285–5291CrossRef

149.

Kumar S, Ul Haq SN, Iqbal SM (2016) The complications of diaphyseal fractures of humerus treated by dynamic compression plate. Gomal J Med Sci 14:167–170

150.

Lee SK, Yang DS, Chang SH, Choy WS (2016) LCP metaphyseal plate fixation for fractures of the distal third humeral shaft using brachialis splitting approach. Acta Orthop Belg 82:85–93PubMed

151.

Lee T, Yoon J (2016) Newly designed minimally invasive plating of a humerus shaft fracture; a different introduction of the plate. Int Orthop. https://doi.org/10.1007/s00264-015-3097-8CrossRefPubMed

152.

Lu S, Wu J, Xu S, Fu B, Dong J, Yang Y et al (2016) Medial approach to treat humeral mid-shaft fractures: a retrospective. J Orthop Surg Res 11:32. https://doi.org/10.1186/s13018-016-0366-1CrossRefPubMedPubMedCentral

153.

Mahajan AS, Kim YG, Kim JH, D’sa P, Lakhani A, Ok HS (2016) Is anterior bridge plating for mid-shaft humeral fractures a suitable option for patients predominantly involved in overhead activities? A functional outcome study in athletes and manual laborers. CIOS Clin Orthop Surg 8:358–366. https://doi.org/10.4055/cios.2016.8.4.358CrossRefPubMed

154.

Mehmood M, Abdul-Rehman-Yaseen M, Farooq S (2016) Compare the functional outcome of dynamic compression platting and locked intramedullary nailing for primary surgical fixation of non-pathological fractures of humeral shaft in adults. Pak J Med Health Sci 10:250–252

155.

Wahed MA, Prasad PN, Reddy N (2016) Prospective study of management of fracture shaft of humerus with locking compression plating. JEMDS 5:1950–1953CrossRef

156.

Bisaccia M, Meccariello L, Rinonapoli G, Rollo G, Pellegrino M, Schiavone A et al (2017) Comparison of plate, nail and external fixation in the management of diaphyseal fractures of the humerus. Med Arch 71:97–102. https://doi.org/10.5455/medarh.2017.71.97-102CrossRefPubMedPubMedCentral

157.

Dielwart C, Harmer L, Thompson J, Seymour RB, Karunakar MA (2017) Management of closed diaphyseal humerus fractures in patients with injury severity score ≥17. J Orthop Trauma 31:220–224. https://doi.org/10.1097/bot.0000000000000768CrossRefPubMed

158.

Duygun F, Aldemir C (2017) Is locked compressive intramedullary nailing for adult humerus shaft fractures advantageous? Eklem Hastalik Cerrahisi 28:80–86. https://doi.org/10.5606/ehc.2017.55687CrossRefPubMed

159.

Harkin FE, Large RJ (2017) Humeral shaft fractures: union outcomes in a large cohort. J Shoulder Elbow Surg 26:1881–1188. https://doi.org/10.1016/j.jse.2017.07.001CrossRefPubMed

160.

Ko SH, Cha JR, Lee CC, Joo YT, Eom KS (2017) Minimally invasive plate osteosynthesis using a screw compression method for treatment of humeral shaft fractures. CIOS Clin Orthop Surg 9:506–513. https://doi.org/10.4055/cios.2017.9.4.506CrossRefPubMed

161.

Matsunaga FT, Tamaoki MJS, Matsumoto MH, Netto NA, Faloppa F, Belloti JC (2017) Minimally invasive osteosynthesis with a bridge plate versus a functional brace for humeral shaft fractures: A randomized controlled trial. J Bone Jt Surg Am 99:583–592. https://doi.org/10.2106/jbjs.16.00628CrossRef

162.

Wei SH, Qinruixian BL, Guangyu D, Chuanxiu S, Xuegang S et al (2017) Comparison study of the clinical effect and biomechanics between locking compression plate and interlocking intramedullary nail for humerus shaft fracture. Biomed Res 28:6251–6255

163.

Crespo AM, Konda SR, Egol KA (2018) Set it and forget it: diaphyseal fractures of the humerus undergo minimal change in angulation after functional brace application. Iowa Orthop J 38:73–77PubMedPubMedCentral

164.

Goncalves FF, Dau L, Grassi CA, Palauro FR, Martins Neto AA, Pereira PCG (2018) Evaluation of the surgical treatment of humeral shaft fractures and comparison between surgical fixation methods. Rev Bras Ortop 53:136–141. https://doi.org/10.1016/j.rboe.2017.03.015CrossRefPubMedPubMedCentral

165.

Ferrara F, Biancardi E, Touloupakis G, Bibiano L, Ghirardelli S, Antonini G et al (2019) Residual interfragmentary gap after intramedullary nailing of fragility fractures of the humeral diaphysis: short and midterm term results. Acta Biomed 90:432–438. https://doi.org/10.23750/abm.v90i4.7315CrossRefPubMedPubMedCentral

166.

Hosseini Khameneh SM, Abbasian M, Abrishamkarzadeh H, Bagheri S, Abdollahimajd F, Safdari F et al (2019) Humeral shaft fracture: a randomized controlled trial of nonoperative versus operative management (plate fixation). Orthop Res Rev 11:141–147. https://doi.org/10.2147/orr.S212998CrossRefPubMedPubMedCentral

167.

Mehraj M, Shah I, Mohd J, Rasool S (2019) Early results of bridge plating of humerus diaphyseal fractures by MIPO technique. Ortop Traumatol Rehabil 21:117–121. https://doi.org/10.5604/01.3001.0013.1915CrossRefPubMed

168.

Pooja Sri S, Subash Y (2019) Comparison of outcome in mipo versus orif with plate osteosynthesis in the management of fractures of the shaft of humerus. Res J Pharm Technol 12:3933–3937. https://doi.org/10.5958/0974-360x.2019.00677.2CrossRef

169.

Seo JB, Heo K, Yang JH, Yoo JS (2019) Clinical outcomes of dual 3.5-mm locking compression plate fixation for humeral shaft fractures: comparison with single 4.5-mm locking compression plate fixation. J Orthop Surg. https://doi.org/10.1177/2309499019839608CrossRef

170.

Vidović D, Benčić I, Ćuti T, Gajski D, Čengić T, Bekić M et al (2019) Treatment of humeral shaft fractures: antegrade interlocking intramedullary nailing with additional interlocking neutralization screws through fracture site. Acta Clin Croat 58:632–638. https://doi.org/10.20471/acc.2019.58.04.10CrossRefPubMedPubMedCentral

171.

Wang Z, Song S, Guo Q, Yang D, Chen X, Ling J et al (2019) Therapeutic effect of anterior approach mipo combined with LCP in the treatment of humeral shaft fracture. Acta Med Mediterr 35:2765–2768. https://doi.org/10.19193/0393-6384_2019_5_434CrossRef

172.

Yuan H, Wang R, Zheng J, Yang Y (2019) Comparison between intramedullary nailing and minimally invasive percutaneous plate osteosynthesis in treatment of humeral shaft fractures. J Coll Phys Surg Pak 29:942–945. https://doi.org/10.29271/jcpsp.2019.10.942CrossRef

173.

Akalin Y, Şahin İG, Çevik N, Güler BO, Avci Ö, Öztürk A (2020) Locking compression plate fixation versus intramedullary nailing of humeral shaft fractures: which one is better? A single-centre prospective randomized study. Int Orthop 44:2113–2121. https://doi.org/10.1007/s00264-020-04696-6CrossRefPubMed

174.

Desai NR, Patil S, Gunaki R (2020) A comparative study of functional outcomes of fracture shaft humerus in adults treated with dynamic compression plating and interlocking nailing. Int J Res Pharm Sci 11:4944–4948. https://doi.org/10.26452/ijrps.v11i3.2798CrossRef

175.

Hendy BA, Zmistowski B, Wells Z, Abboud JA, Namdari S (2020) Humeral shaft fractures: surgical versus nonsurgical management in workers’ compensation. Arch Bone Jt Surg 8:668–674. https://doi.org/10.22038/abjs.2020.44301.2211CrossRefPubMedPubMedCentral

176.

Huichao F, Xiaoming W (2020) Reduced surgical time and higher accuracy of distal locking with the electromagnetic targeting system in humeral shaft intramedullary nailing. Orthop Surg 12:1413–1420. https://doi.org/10.1111/os.12785CrossRefPubMedPubMedCentral

177.

Hussain B, Ullah Z, Hussain G, Napar AR, Latif M, Arif M (2020) Compare the functional outcome of dynamic compression plating versus interlocking nail procedure for fracture shaft of humerus. Pak J Med Health Sci 14:1314–1316

178.

Omrani FA, Rezayian M, Ejlali M, Sayadi S, Baroutkoub M, Omidian MM et al (2020) Intramedullary nailing Vs Plate fixation for the treatment of humeral shaft fractures; which one is better? Syst Rev Pharm 11:770–774. https://doi.org/10.31838/srp.2020.8.111CrossRef

179.

Rai SK, Sud AD, Kashid M, Gogoi B (2020) Anteromedial surface plating for midshaft fracture humerus through an anterolateral approach—a better option than anterolateral plating. Malays Orthop J 14:66–72. https://doi.org/10.5704/moj.2011.011CrossRefPubMedPubMedCentral

180.

Rämö L, Sumrein BO, Lepola V, Lähdeoja T, Ranstam J, Paavola M et al (2020) Effect of surgery vs functional bracing on functional outcome among patients with closed displaced humeral shaft fractures: the FISH randomized clinical trial. JAMA 323:1792–1801. https://doi.org/10.1001/jama.2020.3182CrossRefPubMedPubMedCentral

181.

Sharma GM, Bhardwaj AR, Shah S (2020) Antegrade versus retrograde nailing in humeral shaft fractures: a prospective study. J Clin Orthop Traum 11:S37–S41. https://doi.org/10.1016/j.jcot.2019.04.020CrossRef

182.

Varghese VD, Bhowmick K, Prithishkumar IJ, Nithyananth M (2020) Anteromedial surgical approach for minimally invasive fixation of humerus shaft fractures: a cadaveric and clinical study. Techn Shoulder Elbow Surg 21:42–49. https://doi.org/10.1097/bte.0000000000000188CrossRef

183.

Wang Y, Chen H, Wang L, Chen X, Zhi X, Cui J et al (2020) Comparison between osteosynthesis with interlocking nail and minimally invasive plating for proximal- and middle-thirds of humeral shaft fractures. Int Orthop. https://doi.org/10.1007/s00264-020-04869-3CrossRefPubMed

184.

Wang Y, Kayastha Y, Cao Y, Guo Z, Yuan Y, Bi Y (2020) Outcome of humeral shaft fracture treated with intramedullary nail and plate fixation. J Coll Phys Surg Pak 30:73–78. https://doi.org/10.29271/jcpsp.2020.01.73CrossRef

185.

Yiğit Ş (2020) What should be the timing of surgical treatment of humeral shaft fractures? Medicine (Baltimore) 99:e19858. https://doi.org/10.1097/md.0000000000019858CrossRefPubMed

186.

Zhang R, Yin Y, Li S, Hou Z, Jin L, Zhang Y (2020) Intramedullary nailing versus a locking compression plate for humeral shaft fracture (AO/OTA 12-A and B): a retrospective study. Orthop Traumatol: Surg Res 106:1391–1397. https://doi.org/10.1016/j.otsr.2019.12.016CrossRefPubMed

187.

Cannada LK, Nelson L, Tornetta P, Hymes R, Jones CB, Obremskey W et al (2021) Operative vs nonoperative treatment of isolated humeral shaft fractures: a prospective cohort study. J Surg Orthop Adv 30:67–72PubMed

188.

Capitani P, Chiodini F, Di Mento L, Cavanna M, Bove F, Capitani D et al (2021) Locking compression plate fixation in humeral shaft fractures: a comparative study to literature conservative treatment. Injury. https://doi.org/10.1016/j.injury.2021.03.027CrossRefPubMed

189.

Furuhata R, Kamata Y, Kono A, Kiyota Y, Morioka H (2021) Influence of timing on surgical outcomes for acute humeral shaft fractures. Adv Orthop. https://doi.org/10.1155/2021/8977630CrossRefPubMedPubMedCentral

190.

Huang Q, Lu Y, Wang ZM, Sun L, Ma T, Wang Q et al (2021) Anterolateral approach with two incisions versus posterior median approach in the treatment of middle- and distal-third humeral shaft fractures. J Orthop Surg Res 16:197. https://doi.org/10.1186/s13018-021-02355-zCrossRefPubMedPubMedCentral

191.

Kumar B, Kumar A, Mheshwari LD, Tunio ZH, Jhatiyal RA, Umrani KB (2021) Diaphyseal humeral fractures treated by bracing versus dynamic compression plate. Pak J Med Health Sci 15:1466–1468. https://doi.org/10.53350/pjmhs211561466CrossRef

192.

Mohammed MO, Mahmmod HF, Imam AHF, Almantasir FAF (2021) Intramedullary nailing versus plating for treatment of humeral shaft fractures in adults. Eur J Mol Clin Med 8:2879–2889

193.

Patino JM (2015) Treatment of humeral shaft fractures using antegrade nailing: functional outcome in the shoulder. J Shoulder Elbow Surg 24:1302–1306. https://doi.org/10.1016/j.jse.2015.01.009CrossRefPubMed

194.

Rellán I, Gallucci GL, Donndorff AG, De Carli P, Zaidenberg EE, Richard MJ et al (2021) Time until union in absolute vs relative stability MIPO plating in simple humeral shaft fractures. Eur J Orthop Surg Traumatol. https://doi.org/10.1007/s00590-021-02920-6CrossRefPubMed

195.

Mahabier KC, Den Hartog D, Theyskens N, Verhofstad MHJ, Van Lieshout EMM, HUMMER Investigators (2017) Reliability, validity, responsiveness, and minimal important change of the disabilities of the arm, shoulder and hand and Constant–Murley scores in patients with a humeral shaft fracture. J Shoulder Elbow Surg 26:e1–e12. https://doi.org/10.1016/j.jse.2016.07.072CrossRefPubMed

196.

Hudak PL, Amadio PC, Bombardier C (1996) Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG). Am J Ind Med 29:602–608CrossRefPubMed

197.

Smith MV, Calfee RP, Baumgarten KM, Brophy RH, Wright RW (2012) Upper extremity-specific measures of disability and outcomes in orthopaedic surgery. J Bone Jt Surg Am 94(3):277–285. https://doi.org/10.2106/JBJS.J.01744CrossRef

198.

Constant CR, Murley AH (1987) A clinical method of functional assessment of the shoulder. Clin Orthop Relat Res 214:160–164CrossRef

199.

Amstutz HC, Sew Hoy AL, Clarke IC (1981) UCLA anatomic total shoulder arthroplasty. Clin Orthop Relat Res 155:7–20CrossRef

200.

Richards RR, An KN, Bigliani LU, Friedman RJ, Gartsman GM, Gristina AG et al (1994) A standardized method for the assessment of shoulder function. J Shoulder Elbow Surg 3:347–352. https://doi.org/10.1016/S1058-2746(09)80019-0CrossRefPubMed

201.

Morrey BF, Adams RA (1992) Semiconstrained arthroplasty for the treatment of rheumatoid arthritis of the elbow. J Bone Jt Surg Am 74:479–490CrossRef

Title: Humeral shaft fracture: systematic review of non-operative and operative treatment
Authors: Saskia H. Van Bergen
Kiran C. Mahabier
Esther M. M. Van Lieshout
Tim Van der Torre
Cornelia A. W. Notenboom
Priscilla A. Jawahier
Michael H. J. Verhofstad
Dennis Den Hartog
Publication date: 24-04-2023
Publisher: Springer Berlin Heidelberg
Keywords: Radial Nerve Palsy
Fracture Healing
Humeral Shaft Fracture
Published in: Archives of Orthopaedic and Trauma Surgery / Issue 8/2023
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI: https://doi.org/10.1007/s00402-023-04836-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Humeral shaft fracture: systematic review of non-operative and operative treatment

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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