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Published in: Cancer and Metastasis Reviews 4/2022

26-09-2022 | Photodynamic Therapy | Non-Thematic Review

Increasing cancer permeability by photodynamic priming: from microenvironment to mechanotransduction signaling

Authors: Nazareth Milagros Carigga Gutierrez, Núria Pujol-Solé, Qendresa Arifi, Jean-Luc Coll, Tristan le Clainche, Mans Broekgaarden

Published in: Cancer and Metastasis Reviews | Issue 4/2022

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Abstract

The dense cancer microenvironment is a significant barrier that limits the penetration of anticancer agents, thereby restraining the efficacy of molecular and nanoscale cancer therapeutics. Developing new strategies to enhance the permeability of cancer tissues is of major interest to overcome treatment resistance. Nonetheless, early strategies based on small molecule inhibitors or matrix-degrading enzymes have led to disappointing clinical outcomes by causing increased chemotherapy toxicity and promoting disease progression. In recent years, photodynamic therapy (PDT) has emerged as a novel approach to increase the permeability of cancer tissues. By producing excessive amounts of reactive oxygen species selectively in the cancer microenvironment, PDT increases the accumulation, penetration depth, and efficacy of chemotherapeutics. Importantly, the increased cancer permeability has not been associated to increased metastasis formation. In this review, we provide novel insights into the mechanisms by which this effect, called photodynamic priming, can increase cancer permeability without promoting cell migration and dissemination. This review demonstrates that PDT oxidizes and degrades extracellular matrix proteins, reduces the capacity of cancer cells to adhere to the altered matrix, and interferes with mechanotransduction pathways that promote cancer cell migration and differentiation. Significant knowledge gaps are identified regarding the involvement of critical signaling pathways, and to which extent these events are influenced by the complicated PDT dosimetry. Addressing these knowledge gaps will be vital to further develop PDT as an adjuvant approach to improve cancer permeability, demonstrate the safety and efficacy of this priming approach, and render more cancer patients eligible to receive life-extending treatments.
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Metadata
Title
Increasing cancer permeability by photodynamic priming: from microenvironment to mechanotransduction signaling
Authors
Nazareth Milagros Carigga Gutierrez
Núria Pujol-Solé
Qendresa Arifi
Jean-Luc Coll
Tristan le Clainche
Mans Broekgaarden
Publication date
26-09-2022
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 4/2022
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-022-10064-0

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Dr. Véronique Diéras
Prof. Fabrice Barlesi
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