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Neurology Peripheral Nervous System Disease

Peripheral Nervous System Disease

Autonomic dysfunction after stroke

Central autonomic dysfunction is common in acute stroke and is associated with cardiovascular complications and increased mortality. But novel diagnostic and therapeutic approaches could help manage this disorder.

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Editor's Choice

Framework for decannulation in neurological patients

Decannulation is often complicated by severe dysphagia, reduced cough strength, excessive bronchial secretions, and altered airway anatomy. What diagnostic procedures and therapeutic options are crucial for rehabilitation?

Gait changes: an early warning sign

Growing evidence suggests that age-related gait changes are not a consequence of aging, but instead indicate underlying age-related disease.

Is abdominal pain signaling acute intermittent porphyria?

AIP can easily be overlooked in its early stages. When a patient presents with central, peripheral, or autonomic nervous system symptoms and common causes are ruled out, AIP should be considered.

Promising treatment for DLBCL with neurolymphomatosis

An elderly DLBCL patient with neurolymphomatosis had a full neurological recovery after receiving tafasitamab plus lenalidomide, highlighting the potential of the combination, especially for frail patients.

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Keynote webinar | Spotlight on sleep in brain health

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.

Dr. Rolf Fronczek
Dr. Renata Riha
Dr. Sven Rupprecht
Developed by: Springer Medicine
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Video

Case Studies

Is abdominal pain signaling acute intermittent porphyria?

AIP can easily be overlooked in its early stages. When a patient presents with central, peripheral, or autonomic nervous system symptoms and common causes are ruled out, AIP should be considered.

Promising treatment for DLBCL with neurolymphomatosis

An elderly DLBCL patient with neurolymphomatosis had a full neurological recovery after receiving tafasitamab plus lenalidomide, highlighting the potential of the combination, especially for frail patients.

Progressive optic nerve lesion

Over a 16-year period, transient visual impairment of the patient's left eye progressed to complete visual loss with severe restriction of oculomotor function. How would you diagnose and treat the underlying condition?

Episode 4: Stem cell therapy for PD

A new era for managing Parkinson’s disease?

STEM-PD, the first in-human safety trial of stem cell therapy for Parkinson’s disease, began this year and marks a huge step forward for this type of treatment.

We talk to Prof. Malin Parmar about why stem cell therapy is such a good option for patients with Parkinson’s disease and get an update on the current status of the trial.

Dr. Malin Parmar
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Podcast

Current Reviews

Pain Control Paradigms: A Comparative Review of Anesthesia Techniques in Trigeminal Neuralgia Therapy

This review summarizes the intraoperative anesthesia protocols for radiofrequency thermal coagulation in the treatment of trigeminal neuralgia, focusing on the advantages and disadvantages of two primary anesthesia approaches. The first approach …

Imaging in paraneoplastic neurological syndromes: a comprehensive review

Paraneoplastic neurological syndromes (PNS) are a complex spectrum of clinical syndromes that are associated with underlying malignancies. Majorly being immune-mediated, these syndromes are characterized by the presence of specific paraneoplastic …

Flavonoids regulating NLRP3 inflammasome: a promising approach in alleviating diabetic peripheral neuropathy

A common and serious side effect of diabetes is diabetic peripheral neuropathy (DPN), which is characterised by gradual nerve damage brought on by oxidative stress, chronic inflammation, and prolonged hyperglycemia. Studies identify NLRP3 …

Neurological Deficits Following Regional Anesthesia and Pain Interventions: Reviewing Current Standards of Care

Regional anesthesia (RA) has become an integral part of modern anesthesia practice and acute pain management strategies. It provides effective pain relief, reduces opioid consumption, and facilitates enhanced recovery after surgery. However, like …

Further Reading

Pain Control Paradigms: A Comparative Review of Anesthesia Techniques in Trigeminal Neuralgia Therapy

This review summarizes the intraoperative anesthesia protocols for radiofrequency thermal coagulation in the treatment of trigeminal neuralgia, focusing on the advantages and disadvantages of two primary anesthesia approaches. The first approach …

Long Term Follow-Up of Patients with Cryoglobulinemia After Successful Treatment of Chronic C Virus Hepatitis

According to WHO estimates, hepatitis C virus (HCV) infection affects approximately 2–3% of the world’s population, with an expected number of 350.000 deaths every year [ 1 – 3 ]. Besides its hepatotoxic effects, chronic HCV infection can trigger a …

Flavonoids regulating NLRP3 inflammasome: a promising approach in alleviating diabetic peripheral neuropathy

A common and serious side effect of diabetes is diabetic peripheral neuropathy (DPN), which is characterised by gradual nerve damage brought on by oxidative stress, chronic inflammation, and prolonged hyperglycemia. Studies identify NLRP3 …

Glial fibrillary acidic protein: a potential biomarker for small fiber neuropathy?

Diabetic polyneuropathy (DPN) is a common and debilitating complication of diabetes and associated with substantial health care costs [ 1 ]. Up to 50% of all people with diabetes suffer from DPN and half of these develop neuropathic pain [ 2 , 3 ].