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Published in: Endocrine 1/2024

16-01-2024 | Type 2 Diabetes | Review

Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis

Authors: Yi Pan, Tong Bu, Xia Deng, Jue Jia, Guoyue Yuan

Published in: Endocrine | Issue 1/2024

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Abstract

Type 2 diabetes mellitus (T2DM) has become one of the most serious public healthcare challenges, contributing to increased mortality and disability. In the past decades, significant progress has been made in understanding the pathogenesis of T2DM. Mounting evidence suggested that gut microbiota (GM) plays a significant role in the development of T2DM. Communication between the GM and the brain is a complex bidirectional connection, known as the “gut-brain axis,” via the nervous, neuroendocrine, and immune systems. Gut-brain axis has an essential impact on various physiological processes, including glucose metabolism, food intake, gut motility, etc. In this review, we provide an outline of the gut-brain axis. We also highlight how the dysbiosis of the gut-brain axis affects glucose homeostasis and even results in T2DM.
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Metadata
Title
Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis
Authors
Yi Pan
Tong Bu
Xia Deng
Jue Jia
Guoyue Yuan
Publication date
16-01-2024
Publisher
Springer US
Published in
Endocrine / Issue 1/2024
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-023-03640-z

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