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Neurosyphilis 

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  1. 04-01-2024 | Neurosyphilis | OriginalPaper

    Enhancing clinical awareness: retrospective analysis of neurosyphilis cases and diagnostic predictors for early recognition and treatment

    Syphilis is a chronic, systemic infection transmitted sexually, and it is attributed to infections caused by Treponema pallidum . Neurosyphilis, a distinct manifestation of this disease, arises from the infiltration of T. pallidum into the …

  2. 12-03-2024 | Neurosyphilis | Online First

    Cerebrospinal Fluid Biomarkers of Symptomatic Neurosyphilis in People With HIV Compared with Uninfected Individuals

    We evaluated the diagnostic clinical performance characteristics (DCPC) of cerebrospinal fluid (CSF) total protein (TP), white blood cell count (WBC), and lactate (LA) with different cutoff points as adjunct biomarkers of confirmed or presumptive …

  3. Open Access 01-04-2024 | Neurosyphilis | Online First

    An observational prospective study based on a large cohort of HIV-negative neurosyphilis patients with particular reference to the Jarisch-Herxheimer reaction

    The Jarisch-Herxheimer reaction (JHR) is a febrile transient inflammatory syndrome triggered hours after antibiotic treatment of spirochete infections, including syphilis [ 1 , 2 ]. Clinically, JHR is typically manifested as an abrupt onset of …

  4. Open Access 25-11-2023 | Neurosyphilis | Case Study

    Neurosyphilis presenting with Guillain–Barre syndrome: a case report

    The first electrodiagnostically confirmed case of syphilitic GBS without coexisting confounding infections. It highlights the importance of including syphilis in the differential diagnosis of any patient presenting with ascending polyradiculopathy.

  5. Open Access 01-12-2023 | Neurosyphilis | OriginalPaper

    Establishment of HIV-negative neurosyphilis risk score model based on logistic regression

    Syphilis is a chronic infectious disease with a long history. In the middle of the 1490s, it was first mentioned in Europe. It results from T. pallidum subspecies infection. Nowadays, the incidence of syphilis is gradually increasing. According to …

  6. 03-09-2022 | Magnetic Resonance Imaging | Letter

    The great imitator: latent neurosyphilis presenting with uveitis and labyrinthitis

    Neurosyphilis is caused by infection of the central nervous system (CNS) by the Treponema pallidum spirochete (TPS) [ 1 – 4 ]. Since the introduction of Penicillin, neurosyphilis has become an uncommon disease [ 3 ]. However, in the last century …

  7. 09-09-2022 | Anti-NMDA Receptor Encephalitis | Letter

    Anti-Caspr2 encephalitis coexisting with neurosyphilis: a rare case report

    Neurosyphilis is a central nervous system infectious disease caused by Treponema pallidum. The presentation is traditionally described as dementia, meningitis, meningovascular syphilis, and tabes dorsalis. [ 1 ] However, neurosyphilis can mimic …

  8. Open Access 01-12-2021 | Magnetic Resonance Imaging | OriginalPaper

    Gummatous neurosyphilis in an elderly patient in the Australian outback: a case report

    Syphilis is a sexually transmitted disease that has been present for centuries. It is caused by the spirochete Treponema pallidum and is transmitted horizontally through sexual contact or vertically from mother to baby. Its disease is broadly …

  9. Open Access 01-12-2021 | Syphilis | OriginalPaper

    Development and external validation of a nomogram for neurosyphilis diagnosis among non-HIV patients: a cross-sectional study

    Neurosyphilis (NS) is one of the most feared complications of syphilis [ 1 ], and dissemination of the pathogenic bacterium of neurosyphilis, Treponema pallidum subspecies pallidum , to the cerebrospinal fluid (CSF) and meninges can occur at any …

  10. 30-09-2022 | Magnetic Resonance Imaging | Letter

    Loss of swallow tail sign on susceptibility-weighted imaging in neurosyphilis mimicking Alzheimer’s disease: a case report

    Swallow tail sign (STS), which represents nigrosome-1 in the substantia nigra on susceptibility-weighted imaging (SWI), has been recognized as a promising magnetic resonance imaging (MRI) biomarker for Parkinson’s disease (PD) [ 1 ]. Here, we …

  11. 01-01-2021 | Syphilis | OriginalPaper

    Assessing Utilization of the Cerebrospinal Fluid Venereal Disease Research Laboratory Test for Diagnosis of Neurosyphilis: a Cohort Study

    Appropriate use of diagnostic testing is crucial to providing high-value healthcare. In 2018, national healthcare expenditures in the USA grew to $3.6 trillion, approximately $11,172 per person. 1 The overuse or misuse of screening and diagnostic …

  12. Open Access 01-12-2022 | Syphilis | OriginalPaper

    Ceftriaxone compared with penicillin G for the treatment of neurosyphilis: study protocol for a multicenter randomized controlled trial

    Neurosyphilis is a serious manifestation of syphilis that may cause irreversible damage to the central nervous system (CNS) and even death. The epidemiology of neurosyphilis largely parallels that of syphilis [ 1 , 2 ]. The reported incidence of …

  13. Diagnosis of Creutzfeldt–Jakob disease after neurosyphilis: just bad luck or misdiagnosed?

    In this case report, we want to emphasize the importance of an extensive differential diagnosis and close monitoring of clinical evolution. Both newer diagnostic techniques and the established value of pathology play a vital role in achieving the …

  14. Open Access 01-12-2022 | Magnetic Resonance Imaging | OriginalPaper

    Neurosyphilis with a rare magnetic resonance imaging pattern confirmed by metagenomic next-generation sequencing: a case report

    Syphilis is known as the “Great Imitator” caused by the organism Treponema pallidum . The incidence of syphilis has increased in the past 20 years in China [ 1 ]. It is a sexually transmitted disease, and the clinical course can be divided into …

  15. 01-03-2022 | Magnetic Resonance Imaging | ReviewPaper

    Neurosyphilis in disguise

    Few disorders are restricted or limited to involve the anterior temporal lobes; this is mostly seen due to herpes simplex virus (HSV) encephalitis, mesial temporal sclerosis, post ictal edema, Cerebral Autosomal Recessive Arteriopathy with …

  16. Open Access 01-04-2020 | Syphilis | OriginalPaper

    Neuroimaging Features, Follow-Up Analyses, and Comparisons Between Asymptomatic and Symptomatic Neurosyphilis

    Neurosyphilis (NS) is a syphilitic infection of the central nervous system (CNS) caused by the organism Treponema pallidum , which triggers subacute or chronic inflammation in mesenchymal and parenchymal tissues, finally causing a spectrum of …

  17. Open Access 01-12-2021 | Syphilis | OriginalPaper

    Predicting asymptomatic neurosyphilis using peripheral blood indicators

    Syphilis, asymptomatic or symptomatic, is caused by Treponema pallidum infection and is a serious global health issue [ 1 – 4 ]. Treponema invades the nervous system in about one-third of patients beginning on days following primary infection, and …

  18. 01-12-2021 | Syphilis

    Diagnostic tools for neurosyphilis: a systematic review

    Neurosyphilis is a condition that has challenged physicians for centuries. The invasion of the Central Nervous System by Treponema pallidum subspecies pallidum can result in protean symptoms ranging from vasculitis, stroke, dementia, and meningitis …

  19. Open Access 01-12-2019 | Syphilis | OriginalPaper

    Clinical prediction and diagnosis of neurosyphilis in HIV-negative patients: a case-control study

    Treponema pallidum (T. pallidum) is the causative agent of syphilis, which can invade the central nervous system (CNS) at any stage after exposure [ 1 , 2 ]. In about 14 to 20% of cases, treponema pallidum affects the central nervous system and can …

  20. 01-10-2021 | Meningoencephalitis

    Neurosyphilis: a series of 178 cases at the 3rd-level hospital of Marrakesh (Morocco)

    Neurosyphilis (NS) is an infection of the central nervous system (CNS), caused by Treponema pallidum. Up to 4–10% of patients with untreated syphilis may develop NS which still constitutes a health challenge. The aim of this study is to analyze …

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