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Radiation Oncology
Published in: Radiation Oncology 1/2019

Open Access 01-12-2019 | Review

Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

Authors: Michael Orth, Philipp Metzger, Sabine Gerum, Julia Mayerle, Günter Schneider, Claus Belka, Maximilian Schnurr, Kirsten Lauber

Published in: Radiation Oncology | Issue 1/2019

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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine therapeutic failure. In this review, we present the current status and the recent advances in PDAC treatment together with the biological and immunological hallmarks of this cancer entity. On this basis, we discuss new concepts combining distinct treatment modalities in order to improve therapeutic efficacy and clinical outcome – with a specific focus on protocols involving radio(chemo)therapeutic approaches.
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Metadata
Title
Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
Authors
Michael Orth
Philipp Metzger
Sabine Gerum
Julia Mayerle
Günter Schneider
Claus Belka
Maximilian Schnurr
Kirsten Lauber
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2019
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/s13014-019-1345-6

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