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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2020

01-12-2020 | Osteoarthrosis | Research article

Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases

Authors: Zhuoran Hu, Shuiming Xu, He Lin, Weifeng Ni, Qingyuan Yang, Jun Qi, Keqian Du, Jieruo Gu, Zhiming Lin

Published in: BMC Musculoskeletal Disorders | Issue 1/2020

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Abstract

Backgroud

This study is to explore the prevalence of different stages of bone loss and the potential risk factors in rheumatic patients.

Method

A cross-sectional study recruits 1398 rheumatic patients and 302 healthy subjects. Demographic data, blood, and bone mineral density (BMD) tests are collected. Risk factors for bone loss in rheumatic patients are analyzed by logistic regression.

Results

(1) Rheumatic patients are consisted of 40.0% rheumatoid arthritis (RA), 14.7% systemic lupus erythematosus (SLE), 14.2% osteoarthritis (OA), 9.2% ankylosing spondylosis (AS), 7.9% gout, 7.0% primary Sjogren syndrome (pSS), 3.8% systemic sclerosis (SSc), and 3.2% mixed connective tissue disease (MCTD). (2) In male patients aged under 50 and premenopausal female patients, the bone mineral density score of AS (53.9%, P < 0.001) and SLE (39.6%, P = 0.034) patients is lower than the healthy controls (18.2%). (3) Osteopenia and osteoporosis are more prevailing in male patients aged or older than 50 and postmenopausal female patients with RA (P < 0.001), OA (P = 0.02) and SLE (P = 0.011) than healthy counterparts. (4) Those with SLE, RA and AS gain the highest odd ratio of ‘score below the expected range for age’, osteopenia and osteoporosis, respectively. (5) Age, female, low BMI and hypovitaminosis D are found negatively associated with bone loss. Dyslipidemia and hyperuricemia could be protective factors.

Conclusion

Young patients with AS and SLE have a significant higher occurrence of bone loss, and older patients with RA, OA and SLE had higher prevalence than healthy counterparts. SLE, RA, SSc and AS were founded significant higher risks to develop into bone loss after adjustment. Age, BMI and gender were commonly-associated with bone loss in all age-stratified rheumatic patients. These findings were not markedly different from those of previous studies.
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Metadata
Title
Prevalence and risk factors for bone loss in Southern Chinese with rheumatic diseases
Authors
Zhuoran Hu
Shuiming Xu
He Lin
Weifeng Ni
Qingyuan Yang
Jun Qi
Keqian Du
Jieruo Gu
Zhiming Lin
Publication date
01-12-2020

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