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Published in: Journal of Cardiovascular Translational Research 1/2020

01-02-2020 | Coronary Heart Disease | Review Article

The Influence of Sex on Cardiac Physiology and Cardiovascular Diseases

Authors: Yu Zhang, Bin Liu, Ranzun Zhao, Saidan Zhang, Xi-yong Yu, Yangxin Li

Published in: Journal of Cardiovascular Translational Research | Issue 1/2020

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Abstract

Cardiovascular disease (CVD) is the leading cause of death world-wide. Most of treatment strategies were based on studies conducted on male patients. Studies have shown that significant differences exist between the two sexes in the development of CVD. There are certain differences between men and women in the structure and physiological functions of the heart such as left ventricular mass index, resting heart rate, and contractile function. Accordingly, the pathological features of the heart such as the extend of hypertrophy, fibrosis, and remodeling are also different. In addition, different genders also affect clinical symptoms, responses to treatment and prognosis in the development of CVD. Therefore, it is important to take these differences into consideration when design treatment options for men and women.
Literature
4.
go back to reference Kitzman, D. W., & Edwards, W. D. (1990). Age-related changes in the anatomy of the normal human heart. J Gerontol, 45(2), M33–M39.CrossRefPubMed Kitzman, D. W., & Edwards, W. D. (1990). Age-related changes in the anatomy of the normal human heart. J Gerontol, 45(2), M33–M39.CrossRefPubMed
5.
go back to reference Legato, M. J. (2000). Gender and the heart: sex-specific differences in normal anatomy and physiology. J Gend Specif Med, 3(7), 15–18. Legato, M. J. (2000). Gender and the heart: sex-specific differences in normal anatomy and physiology. J Gend Specif Med, 3(7), 15–18.
6.
go back to reference Nakata, M., Yada, T., Soejima, N., & Maruyama, I. (1999). Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes, 48(2), 426–429.CrossRefPubMed Nakata, M., Yada, T., Soejima, N., & Maruyama, I. (1999). Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes, 48(2), 426–429.CrossRefPubMed
7.
go back to reference Douglas, P. S., Katz, S. E., Weinberg, E. O., Chen, M. H., Bishop, S. P., & Lorell, B. H. (1998). Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload. J Am Coll Cardiol, 32(4), 1118–1125.CrossRefPubMed Douglas, P. S., Katz, S. E., Weinberg, E. O., Chen, M. H., Bishop, S. P., & Lorell, B. H. (1998). Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload. J Am Coll Cardiol, 32(4), 1118–1125.CrossRefPubMed
8.
go back to reference Wallner, M., Duran, J. M., Mohsin, S., Troupes, C. D., Vanhoutte, D., Borghetti, G., Vagnozzi, R. J., Gross, P., Yu, D. H., Trappanese, D. M., Kubo, H., Toib, A., Sharp, T. E., Harper, S. C., Volkert, M. A., Starosta, T., Feldsott, E. A., Berretta, R. M., Wang, T., Barbe, M. F., Molkentin, J. D., & Houser, S. R. (2016). Acute catecholamine exposure causes reversible myocyte injury without cardiac regeneration. Circ Res, 119(7), 865–879. https://doi.org/10.1161/Circresaha.116.308687.CrossRefPubMedPubMedCentral Wallner, M., Duran, J. M., Mohsin, S., Troupes, C. D., Vanhoutte, D., Borghetti, G., Vagnozzi, R. J., Gross, P., Yu, D. H., Trappanese, D. M., Kubo, H., Toib, A., Sharp, T. E., Harper, S. C., Volkert, M. A., Starosta, T., Feldsott, E. A., Berretta, R. M., Wang, T., Barbe, M. F., Molkentin, J. D., & Houser, S. R. (2016). Acute catecholamine exposure causes reversible myocyte injury without cardiac regeneration. Circ Res, 119(7), 865–879. https://​doi.​org/​10.​1161/​Circresaha.​116.​308687.CrossRefPubMedPubMedCentral
9.
go back to reference Wang, F., He, Q., Sun, Y., Dai, X., & Yang, X.-P. (2010). Female adult mouse cardiomyocytes are protected against oxidative stress. Hypertension, 55(5), 1172–1178. Wang, F., He, Q., Sun, Y., Dai, X., & Yang, X.-P. (2010). Female adult mouse cardiomyocytes are protected against oxidative stress. Hypertension, 55(5), 1172–1178.
11.
go back to reference Du, X. J., Samuel, C. S., Gao, X. M., Zhao, L., Parry, L. J., & Tregear, G. W. (2003). Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype. Cardiovasc Res, 57(2), 395–404.CrossRefPubMed Du, X. J., Samuel, C. S., Gao, X. M., Zhao, L., Parry, L. J., & Tregear, G. W. (2003). Increased myocardial collagen and ventricular diastolic dysfunction in relaxin deficient mice: a gender-specific phenotype. Cardiovasc Res, 57(2), 395–404.CrossRefPubMed
14.
go back to reference Johnson, B. D., Shaw, L. J., Buchthal, S. D., Bairey Merz, C. N., Kim, H. W., Scott, K. N., Doyle, M., Olson, M. B., Pepine, C. J., den Hollander, J., Sharaf, B., Rogers, W. J., Mankad, S., Forder, J. R., Kelsey, S. F., Pohost, G. M., & National Institutes of Health-National Heart L, Blood I. (2004). Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Women's ischemia syndrome evaluation (WISE). Circulation, 109(24), 2993–2999. https://doi.org/10.1161/01.CIR.0000130642.79868.B2.CrossRefPubMed Johnson, B. D., Shaw, L. J., Buchthal, S. D., Bairey Merz, C. N., Kim, H. W., Scott, K. N., Doyle, M., Olson, M. B., Pepine, C. J., den Hollander, J., Sharaf, B., Rogers, W. J., Mankad, S., Forder, J. R., Kelsey, S. F., Pohost, G. M., & National Institutes of Health-National Heart L, Blood I. (2004). Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Women's ischemia syndrome evaluation (WISE). Circulation, 109(24), 2993–2999. https://​doi.​org/​10.​1161/​01.​CIR.​0000130642.​79868.​B2.CrossRefPubMed
15.
go back to reference Cho, J. J., Cadet, P., Salamon, E., Mantione, K., & Stefano, G. B. (2003). The nongenomic protective effects of estrogen on the male cardiovascular system: clinical and therapeutic implications in aging men. Med Sci Monit, 9(3), RA63–RA68. Cho, J. J., Cadet, P., Salamon, E., Mantione, K., & Stefano, G. B. (2003). The nongenomic protective effects of estrogen on the male cardiovascular system: clinical and therapeutic implications in aging men. Med Sci Monit, 9(3), RA63–RA68.
19.
go back to reference Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Despres JP, Fullerton HJ, Howard VJ, Huffman MD, Judd SE, Kissela BM, Lackland DT, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Matchar DB, McGuire DK, Mohler ER, 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Willey JZ, Woo D, Yeh RW, Turner MB, American Heart Association Statistics C, Stroke Statistics S (2015) Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation 131 (4):e29–322. doi:https://doi.org/10.1161/CIR.0000000000000152 Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Despres JP, Fullerton HJ, Howard VJ, Huffman MD, Judd SE, Kissela BM, Lackland DT, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Matchar DB, McGuire DK, Mohler ER, 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Willey JZ, Woo D, Yeh RW, Turner MB, American Heart Association Statistics C, Stroke Statistics S (2015) Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation 131 (4):e29–322. doi:https://​doi.​org/​10.​1161/​CIR.​0000000000000152​
22.
go back to reference Burke, A. P., Farb, A., Malcom, G., & Virmani, R. (2001). Effect of menopause on plaque morphologic characteristics in coronary atherosclerosis. Am Heart J, 141(2 Suppl), S58–S62.CrossRefPubMed Burke, A. P., Farb, A., Malcom, G., & Virmani, R. (2001). Effect of menopause on plaque morphologic characteristics in coronary atherosclerosis. Am Heart J, 141(2 Suppl), S58–S62.CrossRefPubMed
24.
go back to reference Hodges, Y. K., Tung, L., Yan, X. D., Graham, J. D., Horwitz, K. B., & Horwitz, L. D. (2000). Estrogen receptors alpha and beta: prevalence of estrogen receptor beta mRNA in human vascular smooth muscle and transcriptional effects. Circulation, 101(15), 1792–1798.CrossRefPubMed Hodges, Y. K., Tung, L., Yan, X. D., Graham, J. D., Horwitz, K. B., & Horwitz, L. D. (2000). Estrogen receptors alpha and beta: prevalence of estrogen receptor beta mRNA in human vascular smooth muscle and transcriptional effects. Circulation, 101(15), 1792–1798.CrossRefPubMed
28.
go back to reference Carmina, E. (2009). Cardiovascular risk and events in polycystic ovary syndrome. Climacteric, 12(Suppl 1), 22–25.CrossRefPubMed Carmina, E. (2009). Cardiovascular risk and events in polycystic ovary syndrome. Climacteric, 12(Suppl 1), 22–25.CrossRefPubMed
32.
go back to reference Sherwood, A., Blumenthal, J. A., Trivedi, R., Johnson, K. S., O'Connor, C. M., Adams, K. F., Jr., Dupree, C. S., Waugh, R. A., Bensimhon, D. R., Gaulden, L., Christenson, R. H., Koch, G. G., & Hinderliter, A. L. (2007). Relationship of depression to death or hospitalization in patients with heart failure. Arch Intern Med, 167(4), 367–373. https://doi.org/10.1001/archinte.167.4.367.CrossRefPubMed Sherwood, A., Blumenthal, J. A., Trivedi, R., Johnson, K. S., O'Connor, C. M., Adams, K. F., Jr., Dupree, C. S., Waugh, R. A., Bensimhon, D. R., Gaulden, L., Christenson, R. H., Koch, G. G., & Hinderliter, A. L. (2007). Relationship of depression to death or hospitalization in patients with heart failure. Arch Intern Med, 167(4), 367–373. https://​doi.​org/​10.​1001/​archinte.​167.​4.​367.CrossRefPubMed
34.
go back to reference Yusuf, S., Hawken, S., Ounpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., Lisheng, L., & Investigators, I. S. (2004). Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet, 364(9438), 937–952. https://doi.org/10.1016/S0140-6736(04)17018-9.CrossRefPubMed Yusuf, S., Hawken, S., Ounpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., Lisheng, L., & Investigators, I. S. (2004). Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet, 364(9438), 937–952. https://​doi.​org/​10.​1016/​S0140-6736(04)17018-9.CrossRefPubMed
35.
go back to reference Orth-Gomer, K., Wamala, S. P., Horsten, M., Schenck-Gustafsson, K., Schneiderman, N., & Mittleman, M. A. (2000). Marital stress worsens prognosis in women with coronary heart disease: the Stockholm Female Coronary Risk Study. Jama, 284(23), 3008–3014.CrossRefPubMed Orth-Gomer, K., Wamala, S. P., Horsten, M., Schenck-Gustafsson, K., Schneiderman, N., & Mittleman, M. A. (2000). Marital stress worsens prognosis in women with coronary heart disease: the Stockholm Female Coronary Risk Study. Jama, 284(23), 3008–3014.CrossRefPubMed
36.
go back to reference Rosengren, A., Hawken, S., Ounpuu, S., Sliwa, K., Zubaid, M., Almahmeed, W. A., Blackett, K. N., Sitthi-amorn, C., Sato, H., Yusuf, S., & investigators I. (2004). Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study. Lancet, 364(9438), 953–962. https://doi.org/10.1016/S0140-6736(04)17019-0.CrossRefPubMed Rosengren, A., Hawken, S., Ounpuu, S., Sliwa, K., Zubaid, M., Almahmeed, W. A., Blackett, K. N., Sitthi-amorn, C., Sato, H., Yusuf, S., & investigators I. (2004). Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study. Lancet, 364(9438), 953–962. https://​doi.​org/​10.​1016/​S0140-6736(04)17019-0.CrossRefPubMed
38.
go back to reference Drory, Y., Kravetz, S., Hirschberger, G., & Israel Study Group on First Acute Myocardial I. (2003). Long-term mental health of women after a first acute myocardial infarction. Arch Phys Med Rehabil, 84(10), 1492–1498. Drory, Y., Kravetz, S., Hirschberger, G., & Israel Study Group on First Acute Myocardial I. (2003). Long-term mental health of women after a first acute myocardial infarction. Arch Phys Med Rehabil, 84(10), 1492–1498.
39.
go back to reference Barefoot, J. C., Helms, M. J., Mark, D. B., Blumenthal, J. A., Califf, R. M., Haney, T. L., O’Connor, C. M., Siegler, I. C., & Williams, R. B. (1996). Depression and long-term mortality risk in patients with coronary artery disease. Am J Cardiol, 78(6), 613–617.CrossRefPubMed Barefoot, J. C., Helms, M. J., Mark, D. B., Blumenthal, J. A., Califf, R. M., Haney, T. L., O’Connor, C. M., Siegler, I. C., & Williams, R. B. (1996). Depression and long-term mortality risk in patients with coronary artery disease. Am J Cardiol, 78(6), 613–617.CrossRefPubMed
40.
go back to reference Anderson, R. J., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001). The prevalence of comorbid depression in adults with diabetes: A meta-analysis. Diabetes Care, 24(6), 1069–1078.CrossRefPubMed Anderson, R. J., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001). The prevalence of comorbid depression in adults with diabetes: A meta-analysis. Diabetes Care, 24(6), 1069–1078.CrossRefPubMed
43.
go back to reference Huxley, R. R., & Woodward, M. (2011). Cigarette smoking as a risk factor for coronary heart disease in women compared with men: a systematic review and meta-analysis of prospective cohort studies. Lancet, 378(9799), 1297–1305. Huxley, R. R., & Woodward, M. (2011). Cigarette smoking as a risk factor for coronary heart disease in women compared with men: a systematic review and meta-analysis of prospective cohort studies. Lancet, 378(9799), 1297–1305.
44.
go back to reference Yusuf, S., Reddy, S., Ounpuu, S., & Anand, S. (2001). Global burden of cardiovascular diseases: Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies. Circulation, 104(23), 2855–2864. Yusuf, S., Reddy, S., Ounpuu, S., & Anand, S. (2001). Global burden of cardiovascular diseases: Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies. Circulation, 104(23), 2855–2864.
46.
go back to reference Willett, W., Hennekens, C. H., Castelli, W., Rosner, B., Evans, D., Taylor, J., & Kass, E. H. (1983). Effects of cigarette smoking on fasting triglyceride, total cholesterol, and HDL-cholesterol in women. Am Heart J, 105(3), 417–421.CrossRefPubMed Willett, W., Hennekens, C. H., Castelli, W., Rosner, B., Evans, D., Taylor, J., & Kass, E. H. (1983). Effects of cigarette smoking on fasting triglyceride, total cholesterol, and HDL-cholesterol in women. Am Heart J, 105(3), 417–421.CrossRefPubMed
48.
go back to reference Kearney, P. M., Whelton, M., Reynolds, K., Whelton, P. K., & He, J. (2004). Worldwide prevalence of hypertension: a systematic review. J Hypertens, 22(1), 11–19. Kearney, P. M., Whelton, M., Reynolds, K., Whelton, P. K., & He, J. (2004). Worldwide prevalence of hypertension: a systematic review. J Hypertens, 22(1), 11–19.
52.
go back to reference Gu, D., Reynolds, K., Wu, X., Chen, J., Duan, X., Muntner, P., Huang, G., Reynolds, R. F., Su, S., Whelton, P. K., He, J., & Inter ACGTICSoCDiA. (2002). Prevalence, awareness, treatment, and control of hypertension in China. Hypertension, 40(6), 920–927.CrossRefPubMed Gu, D., Reynolds, K., Wu, X., Chen, J., Duan, X., Muntner, P., Huang, G., Reynolds, R. F., Su, S., Whelton, P. K., He, J., & Inter ACGTICSoCDiA. (2002). Prevalence, awareness, treatment, and control of hypertension in China. Hypertension, 40(6), 920–927.CrossRefPubMed
56.
go back to reference Regitz-Zagrosek, V., Lehmkuhl, E., & Weickert, M. O. (2006). Gender differences in the metabolic syndrome and their role for cardiovascular disease. Clin Res Cardiol, 95(3), 136–147.CrossRefPubMed Regitz-Zagrosek, V., Lehmkuhl, E., & Weickert, M. O. (2006). Gender differences in the metabolic syndrome and their role for cardiovascular disease. Clin Res Cardiol, 95(3), 136–147.CrossRefPubMed
57.
go back to reference Barrett-Connor, E. L., Cohn, B. A., Wingard, D. L., & Edelstein, S. L. (1991). Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study. Jama, 265(5), 627–631.CrossRefPubMed Barrett-Connor, E. L., Cohn, B. A., Wingard, D. L., & Edelstein, S. L. (1991). Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study. Jama, 265(5), 627–631.CrossRefPubMed
59.
go back to reference Bello, N., & Mosca, L. (2004). Epidemiology of coronary heart disease in women. Prog Cardiovasc Dis, 46(4), 287–295.CrossRefPubMed Bello, N., & Mosca, L. (2004). Epidemiology of coronary heart disease in women. Prog Cardiovasc Dis, 46(4), 287–295.CrossRefPubMed
60.
go back to reference Hokanson, J. E., & Austin, M. A. (1996). Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk, 3(2), 213–219.CrossRefPubMed Hokanson, J. E., & Austin, M. A. (1996). Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk, 3(2), 213–219.CrossRefPubMed
62.
go back to reference Matthews, K. A., Kuller, L. H., Sutton-Tyrrell, K., & Chang, Y. F. (2001). Changes in cardiovascular risk factors during the perimenopause and postmenopause and carotid artery atherosclerosis in healthy women. Stroke, 32(5), 1104–1111.CrossRefPubMed Matthews, K. A., Kuller, L. H., Sutton-Tyrrell, K., & Chang, Y. F. (2001). Changes in cardiovascular risk factors during the perimenopause and postmenopause and carotid artery atherosclerosis in healthy women. Stroke, 32(5), 1104–1111.CrossRefPubMed
63.
go back to reference Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., Plodkowski, R., & Reviewers of the AACEOCPG. (2016). American Association Of Clinical Endocrinologists And American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract, 22(Suppl 3), 1–203. https://doi.org/10.4158/EP161365.GL.CrossRefPubMed Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., Plodkowski, R., & Reviewers of the AACEOCPG. (2016). American Association Of Clinical Endocrinologists And American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. Endocr Pract, 22(Suppl 3), 1–203. https://​doi.​org/​10.​4158/​EP161365.​GL.CrossRefPubMed
64.
go back to reference Hansen, L., Netterstrom, M. K., Johansen, N. B., Ronn, P. F., Vistisen, D., Husemoen, L. L. N., Jorgensen, M. E., Rod, N. H., & Faerch, K. (2017). Metabolically healthy obesity and ischemic heart disease: a 10-year follow-up of the Inter99 Study. J CLIN ENDOCR METAB , 102(6), 1934–1942. https://doi.org/10.1210/jc.2016-3346.CrossRef Hansen, L., Netterstrom, M. K., Johansen, N. B., Ronn, P. F., Vistisen, D., Husemoen, L. L. N., Jorgensen, M. E., Rod, N. H., & Faerch, K. (2017). Metabolically healthy obesity and ischemic heart disease: a 10-year follow-up of the Inter99 Study. J CLIN ENDOCR METAB , 102(6), 1934–1942. https://​doi.​org/​10.​1210/​jc.​2016-3346.CrossRef
71.
go back to reference Lee, D.-c., Artero, E. G., Sui, X., & Blair, S. N. (2010). Mortality trends in the general population: the importance of cardiorespiratory fitness. J Psychopharmacol, 24(4 Suppl), 27–35.CrossRefPubMedPubMedCentral Lee, D.-c., Artero, E. G., Sui, X., & Blair, S. N. (2010). Mortality trends in the general population: the importance of cardiorespiratory fitness. J Psychopharmacol, 24(4 Suppl), 27–35.CrossRefPubMedPubMedCentral
72.
go back to reference Manson, J. E., Greenland, P., LaCroix, A. Z., Stefanick, M. L., Mouton, C. P., Oberman, A., Perri, M. G., Sheps, D. S., Pettinger, M. B., & Siscovick, D. S. (2002). Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med, 347(10), 716–725. https://doi.org/10.1056/NEJMoa021067.CrossRefPubMed Manson, J. E., Greenland, P., LaCroix, A. Z., Stefanick, M. L., Mouton, C. P., Oberman, A., Perri, M. G., Sheps, D. S., Pettinger, M. B., & Siscovick, D. S. (2002). Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med, 347(10), 716–725. https://​doi.​org/​10.​1056/​NEJMoa021067.CrossRefPubMed
73.
go back to reference Lakshman, R., Forouhi, N. G., Sharp, S. J., Luben, R., Bingham, S. A., Khaw, K.-T., Wareham, N. J., & Ong, K. K. (2009). Early age at menarche associated with cardiovascular disease and mortality. J Clin Endocrinol Metab, 94(12), 4953–4960.CrossRefPubMed Lakshman, R., Forouhi, N. G., Sharp, S. J., Luben, R., Bingham, S. A., Khaw, K.-T., Wareham, N. J., & Ong, K. K. (2009). Early age at menarche associated with cardiovascular disease and mortality. J Clin Endocrinol Metab, 94(12), 4953–4960.CrossRefPubMed
74.
go back to reference Canoy, D., Beral, V., Balkwill, A., Wright, F. L., Kroll, M. E., Reeves, G. K., Green, J., Cairns, B. J., Million Women Study, C., Abbiss, H., Abbott, S., Allen, N., Armstrong, M., Balkwill, A., Banks, E., Benson, V., Beral, V., Black, J., Bradbury, K., Brown, A., Cairns, B., Canfell, K., Canoy, D., Crossley, B., Ewart, D., Ewart, S., Fletcher, L., Floud, S., Gathani, T., Gerrard, L., Goodill, A., Green, J., Guiver, L., Lingard, I., Wan Kan, S., Kirichek, O., Kroll, M., Langston, N., Liu, B., Luque, M.-J., Moser, K., Pank, L., Pirie, K., Reeves, G., Shaw, K., Sherman, E., Sherry-Starmer, E., Strange, H., Sweetland, S., Timadjer, A., Tipper, S., Travis, R., Wright, L., Yang, O., Young, H., Banks, E., Beral, V., English, R., Green, J., Patnick, J., Peto, R., Reeves, G., Vessey, M., & Wallis, M. (2015). Age at menarche and risks of coronary heart and other vascular diseases in a large UK cohort. Circulation, 131(3), 237–244.CrossRefPubMed Canoy, D., Beral, V., Balkwill, A., Wright, F. L., Kroll, M. E., Reeves, G. K., Green, J., Cairns, B. J., Million Women Study, C., Abbiss, H., Abbott, S., Allen, N., Armstrong, M., Balkwill, A., Banks, E., Benson, V., Beral, V., Black, J., Bradbury, K., Brown, A., Cairns, B., Canfell, K., Canoy, D., Crossley, B., Ewart, D., Ewart, S., Fletcher, L., Floud, S., Gathani, T., Gerrard, L., Goodill, A., Green, J., Guiver, L., Lingard, I., Wan Kan, S., Kirichek, O., Kroll, M., Langston, N., Liu, B., Luque, M.-J., Moser, K., Pank, L., Pirie, K., Reeves, G., Shaw, K., Sherman, E., Sherry-Starmer, E., Strange, H., Sweetland, S., Timadjer, A., Tipper, S., Travis, R., Wright, L., Yang, O., Young, H., Banks, E., Beral, V., English, R., Green, J., Patnick, J., Peto, R., Reeves, G., Vessey, M., & Wallis, M. (2015). Age at menarche and risks of coronary heart and other vascular diseases in a large UK cohort. Circulation, 131(3), 237–244.CrossRefPubMed
76.
go back to reference Juliard, J. M., Golmard, J. L., Himbert, D., Feldman, L. J., Delorme, L., Ducrocq, G., Descoutures, F., Sorbets, E., Garbarz, E., Boudvillain, O., Aubry, P., Vahanian, A., & Steg, P. G. (2013). Comparison of hospital mortality during ST-segment elevation myocardial infarction in the era of reperfusion therapy in women versus men and in older versus younger patients. Am J Cardiol, 111(12), 1708–1713. https://doi.org/10.1016/j.amjcard.2013.02.023.CrossRefPubMed Juliard, J. M., Golmard, J. L., Himbert, D., Feldman, L. J., Delorme, L., Ducrocq, G., Descoutures, F., Sorbets, E., Garbarz, E., Boudvillain, O., Aubry, P., Vahanian, A., & Steg, P. G. (2013). Comparison of hospital mortality during ST-segment elevation myocardial infarction in the era of reperfusion therapy in women versus men and in older versus younger patients. Am J Cardiol, 111(12), 1708–1713. https://​doi.​org/​10.​1016/​j.​amjcard.​2013.​02.​023.CrossRefPubMed
78.
go back to reference Carr, D. B., Utzschneider, K. M., Hull, R. L., Tong, J., Wallace, T. M., Kodama, K., Shofer, J. B., Heckbert, S. R., Boyko, E. J., Fujimoto, W. Y., & Kahn, S. E. (2006). Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Diabetes Care, 29(9), 2078–2083. https://doi.org/10.2337/dc05-2482.CrossRefPubMed Carr, D. B., Utzschneider, K. M., Hull, R. L., Tong, J., Wallace, T. M., Kodama, K., Shofer, J. B., Heckbert, S. R., Boyko, E. J., Fujimoto, W. Y., & Kahn, S. E. (2006). Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Diabetes Care, 29(9), 2078–2083. https://​doi.​org/​10.​2337/​dc05-2482.CrossRefPubMed
79.
go back to reference Archambault, C., Arel, R., & Filion, K. B. (2014). Gestational diabetes and risk of cardiovascular disease: a scoping review. Open Med, 8(1), e1–e9. Archambault, C., Arel, R., & Filion, K. B. (2014). Gestational diabetes and risk of cardiovascular disease: a scoping review. Open Med, 8(1), e1–e9.
81.
go back to reference Anderson, G. L., Limacher, M., Assaf, A. R., Bassford, T., Beresford, S. A., Black, H., Bonds, D., Brunner, R., Brzyski, R., Caan, B., Chlebowski, R., Curb, D., Gass, M., Hays, J., Heiss, G., Hendrix, S., Howard, B. V., Hsia, J., Hubbell, A., Jackson, R., Johnson, K. C., Judd, H., Kotchen, J. M., Kuller, L., LaCroix, A. Z., Lane, D., Langer, R. D., Lasser, N., Lewis, C. E., Manson, J., Margolis, K., Ockene, J., O'Sullivan, M. J., Phillips, L., Prentice, R. L., Ritenbaugh, C., Robbins, J., Rossouw, J. E., Sarto, G., Stefanick, M. L., Van Horn, L., Wactawski-Wende, J., Wallace, R., Wassertheil-Smoller, S., & Women’s Health Initiative Steering, C. (2004). Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. Jama, 291(14), 1701–1712. https://doi.org/10.1001/jama.291.14.1701.CrossRefPubMed Anderson, G. L., Limacher, M., Assaf, A. R., Bassford, T., Beresford, S. A., Black, H., Bonds, D., Brunner, R., Brzyski, R., Caan, B., Chlebowski, R., Curb, D., Gass, M., Hays, J., Heiss, G., Hendrix, S., Howard, B. V., Hsia, J., Hubbell, A., Jackson, R., Johnson, K. C., Judd, H., Kotchen, J. M., Kuller, L., LaCroix, A. Z., Lane, D., Langer, R. D., Lasser, N., Lewis, C. E., Manson, J., Margolis, K., Ockene, J., O'Sullivan, M. J., Phillips, L., Prentice, R. L., Ritenbaugh, C., Robbins, J., Rossouw, J. E., Sarto, G., Stefanick, M. L., Van Horn, L., Wactawski-Wende, J., Wallace, R., Wassertheil-Smoller, S., & Women’s Health Initiative Steering, C. (2004). Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. Jama, 291(14), 1701–1712. https://​doi.​org/​10.​1001/​jama.​291.​14.​1701.CrossRefPubMed
86.
go back to reference Sheifer, S. E., Canos, M. R., Weinfurt, K. P., Arora, U. K., Mendelsohn, F. O., Gersh, B. J., & Weissman, N. J. (2000). Sex differences in coronary artery size assessed by intravascular ultrasound. Am Heart J, 139(4), 649–653.CrossRefPubMed Sheifer, S. E., Canos, M. R., Weinfurt, K. P., Arora, U. K., Mendelsohn, F. O., Gersh, B. J., & Weissman, N. J. (2000). Sex differences in coronary artery size assessed by intravascular ultrasound. Am Heart J, 139(4), 649–653.CrossRefPubMed
87.
go back to reference Lansky, A. J., Hochman, J. S., Ward, P. A., Mintz, G. S., Fabunmi, R., Berger, P. B., New, G., Grines, C. L., Pietras, C. G., Kern, M. J., Ferrell, M., Leon, M. B., Mehran, R., White, C., Mieres, J. H., Moses, J. W., Stone, G. W., Jacobs, A. K., & American College of Cardiology F, American Heart A. (2005). Percutaneous coronary intervention and adjunctive pharmacotherapy in women: a statement for healthcare professionals from the American Heart Association. Circulation, 111(7), 940–953.CrossRefPubMed Lansky, A. J., Hochman, J. S., Ward, P. A., Mintz, G. S., Fabunmi, R., Berger, P. B., New, G., Grines, C. L., Pietras, C. G., Kern, M. J., Ferrell, M., Leon, M. B., Mehran, R., White, C., Mieres, J. H., Moses, J. W., Stone, G. W., Jacobs, A. K., & American College of Cardiology F, American Heart A. (2005). Percutaneous coronary intervention and adjunctive pharmacotherapy in women: a statement for healthcare professionals from the American Heart Association. Circulation, 111(7), 940–953.CrossRefPubMed
89.
go back to reference Arnold, A. M., Mick, M. J., Piedmonte, M. R., & Simpfendorfer, C. (1994). Gender differences for coronary angioplasty. Am J Cardiol, 74(1), 18–21.CrossRefPubMed Arnold, A. M., Mick, M. J., Piedmonte, M. R., & Simpfendorfer, C. (1994). Gender differences for coronary angioplasty. Am J Cardiol, 74(1), 18–21.CrossRefPubMed
91.
go back to reference Bearden, D., Allman, R., McDonald, R., Miller, S., Pressel, S., & Petrovitch, H. (1994). Age, race, and gender variation in the utilization of coronary artery bypass surgery and angioplasty in SHEP. SHEP Cooperative Research Group. Systolic Hypertension in the Elderly Program. J Am Geriatr Soc, 42(11), 1143–1149.CrossRefPubMed Bearden, D., Allman, R., McDonald, R., Miller, S., Pressel, S., & Petrovitch, H. (1994). Age, race, and gender variation in the utilization of coronary artery bypass surgery and angioplasty in SHEP. SHEP Cooperative Research Group. Systolic Hypertension in the Elderly Program. J Am Geriatr Soc, 42(11), 1143–1149.CrossRefPubMed
92.
go back to reference Kelsey, S. F., James, M., Holubkov, A. L., Holubkov, R., Cowley, M. J., & Detre, K. M. (1993). Results of percutaneous transluminal coronary angioplasty in women. 1985-1986 National Heart, Lung, and Blood Institute’s Coronary Angioplasty Registry. Circulation, 87(3), 720–727.CrossRefPubMed Kelsey, S. F., James, M., Holubkov, A. L., Holubkov, R., Cowley, M. J., & Detre, K. M. (1993). Results of percutaneous transluminal coronary angioplasty in women. 1985-1986 National Heart, Lung, and Blood Institute’s Coronary Angioplasty Registry. Circulation, 87(3), 720–727.CrossRefPubMed
93.
go back to reference Ellis, S. G., Roubin, G. S., King, S. B., 3rd, Douglas, J. S., Jr., Shaw, R. E., Stertzer, S. H., & Myler, R. K. (1988). In-hospital cardiac mortality after acute closure after coronary angioplasty: analysis of risk factors from 8,207 procedures. J Am Coll Cardiol, 11(2), 211–216.CrossRefPubMed Ellis, S. G., Roubin, G. S., King, S. B., 3rd, Douglas, J. S., Jr., Shaw, R. E., Stertzer, S. H., & Myler, R. K. (1988). In-hospital cardiac mortality after acute closure after coronary angioplasty: analysis of risk factors from 8,207 procedures. J Am Coll Cardiol, 11(2), 211–216.CrossRefPubMed
94.
go back to reference Rosano, G. M., Lewis, B., Agewall, S., Wassmann, S., Vitale, C., Schmidt, H., Drexel, H., Patak, A., Torp-Pedersen, C., Kjeldsen, K. P., & Tamargo, J. (2015). Gender differences in the effect of cardiovascular drugs: a position document of the Working Group on Pharmacology and Drug Therapy of the ESC. Eur Heart J, 36(40), 2677–2680. https://doi.org/10.1093/eurheartj/ehv161.CrossRefPubMed Rosano, G. M., Lewis, B., Agewall, S., Wassmann, S., Vitale, C., Schmidt, H., Drexel, H., Patak, A., Torp-Pedersen, C., Kjeldsen, K. P., & Tamargo, J. (2015). Gender differences in the effect of cardiovascular drugs: a position document of the Working Group on Pharmacology and Drug Therapy of the ESC. Eur Heart J, 36(40), 2677–2680. https://​doi.​org/​10.​1093/​eurheartj/​ehv161.CrossRefPubMed
95.
go back to reference Martinez-Selles, M., Doughty, R. N., Poppe, K., Whalley, G. A., Earle, N., Tribouilloy, C., McMurray, J. J., Swedberg, K., Kober, L., Berry, C., Squire, I., & Meta-Analysis Global Group In Chronic Heart F. (2012). Gender and survival in patients with heart failure: interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta-analysis. Eur J Heart Fail, 14(5), 473–479. https://doi.org/10.1093/eurjhf/hfs026.CrossRefPubMed Martinez-Selles, M., Doughty, R. N., Poppe, K., Whalley, G. A., Earle, N., Tribouilloy, C., McMurray, J. J., Swedberg, K., Kober, L., Berry, C., Squire, I., & Meta-Analysis Global Group In Chronic Heart F. (2012). Gender and survival in patients with heart failure: interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta-analysis. Eur J Heart Fail, 14(5), 473–479. https://​doi.​org/​10.​1093/​eurjhf/​hfs026.CrossRefPubMed
96.
go back to reference Jani, S. M., Montoye, C. K., Chen, B., Roychoudhury, C., & Eagle, K. A. (2005). Gender differences in the application of evidence-based therapies for the treatment of acute myocardial infarction: the American College of Cardiology’s Guidelines Applied in Practice (GAP) projects in Michigan. J Am Coll Cardiol, 45(3), 346a–346a. Jani, S. M., Montoye, C. K., Chen, B., Roychoudhury, C., & Eagle, K. A. (2005). Gender differences in the application of evidence-based therapies for the treatment of acute myocardial infarction: the American College of Cardiology’s Guidelines Applied in Practice (GAP) projects in Michigan. J Am Coll Cardiol, 45(3), 346a–346a.
97.
go back to reference Song, X. T., Chen, Y. D., Pan, W. Q., Lu, S. Z., & investigators C. (2007). Gender based differences in patients with acute coronary syndrome: findings from Chinese Registry of Acute Coronary Events (CRACE). Chin Med J, 120(12), 1063–1067.CrossRefPubMed Song, X. T., Chen, Y. D., Pan, W. Q., Lu, S. Z., & investigators C. (2007). Gender based differences in patients with acute coronary syndrome: findings from Chinese Registry of Acute Coronary Events (CRACE). Chin Med J, 120(12), 1063–1067.CrossRefPubMed
Metadata
Title
The Influence of Sex on Cardiac Physiology and Cardiovascular Diseases
Authors
Yu Zhang
Bin Liu
Ranzun Zhao
Saidan Zhang
Xi-yong Yu
Yangxin Li
Publication date
01-02-2020
Publisher
Springer US
Published in
Journal of Cardiovascular Translational Research / Issue 1/2020
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-019-09898-x

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