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Current HIV/AIDS Reports
Published in: Current HIV/AIDS Reports 3/2019

01-06-2019 | Human Immunodeficiency Virus | HIV Pathogenesis and Treatment (AL Landay and NS Utay, Section Editors)

Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection

Authors: Emily Bowman, Nicholas T. Funderburg

Published in: Current HIV/AIDS Reports | Issue 3/2019

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Abstract

Purpose of Review

Human immunodeficiency virus (HIV) infection and its treatment with antiretroviral therapy (ART) are associated with lipid abnormalities that may enhance cardiovascular disease risk (CVD).

Recent Findings

Chronic inflammation persists in HIV+ individuals, and complex relationships exist among lipids and inflammation, as immune activation may be both a cause and a consequence of lipid abnormalities in HIV infection. Advances in mass spectrometry-based techniques now allow for detailed measurements of individual lipid species; improved lipid measurement might better evaluate CVD risk compared with the prognostic value of traditional assessments.

Summary

Lipidomic analyses have begun to characterize dynamic changes in lipid composition during HIV infection and following treatment with ART, and further investigation may identify novel lipid biomarkers predictive of adverse outcomes. Developing strategies to improve management of comorbidities in the HIV+ population is important, and statin therapy and lifestyle modifications, including diet and exercise, may help to improve lipid levels and mitigate CVD risk.
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Metadata
Title
Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection
Authors
Emily Bowman
Nicholas T. Funderburg
Publication date
01-06-2019
Publisher
Springer US
Published in
Current HIV/AIDS Reports / Issue 3/2019
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-019-00442-9

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