Skip to main content
Top
Published in: Neurological Sciences 10/2021

01-10-2021 | Alkaloids | Review Article

Chemotherapy and peripheral neuropathy

Authors: Tiffany Li, David Mizrahi, David Goldstein, Matthew C. Kiernan, Susanna B. Park

Published in: Neurological Sciences | Issue 10/2021

Login to get access

Abstract

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major dose-limiting side effect of many anti-cancer agents, including taxanes, platinums, vinca alkaloids, proteasome inhibitors, immunomodulatory drugs, and antibody–drug conjugates. The resultant symptoms often persist post treatment completion and continue to impact on long-term function and quality of life for cancer survivors. At present, dose reduction remains the only strategy to prevent severe neuropathy, often leading clinicians to the difficult decision of balancing maximal treatment exposure and minimal long-lasting side effects. This review examines the clinical presentations of CIPN with each class of neurotoxic treatment, describing signs, symptoms, and long-term outcomes. We provide an update on the proposed mechanisms of nerve damage and review current data on clinical and genetic risk factors contributing to CIPN development. We also examine recent areas of research in the treatment and prevention of CIPN, with specific focus on current clinical trials and consensus recommendations for CIPN management.
Literature
5.
go back to reference Hershman DL, Weimer LH, Wang A, Kranwinkel G, Brafman L, Fuentes D, Awad D et al (2011) Association between patient reported outcomes and quantitative sensory tests for measuring long-term neurotoxicity in breast cancer survivors treated with adjuvant paclitaxel chemotherapy. Breast Cancer Res Treat 125(3):767–774. https://doi.org/10.1007/s10549-010-1278-0CrossRefPubMed Hershman DL, Weimer LH, Wang A, Kranwinkel G, Brafman L, Fuentes D, Awad D et al (2011) Association between patient reported outcomes and quantitative sensory tests for measuring long-term neurotoxicity in breast cancer survivors treated with adjuvant paclitaxel chemotherapy. Breast Cancer Res Treat 125(3):767–774. https://​doi.​org/​10.​1007/​s10549-010-1278-0CrossRefPubMed
8.
go back to reference Swain SM, Arezzo JC (2008) Neuropathy associated with microtubule inhibitors: diagnosis, incidence, and management. Clin Adv Hematol Oncol 6(6):455–467PubMed Swain SM, Arezzo JC (2008) Neuropathy associated with microtubule inhibitors: diagnosis, incidence, and management. Clin Adv Hematol Oncol 6(6):455–467PubMed
26.
go back to reference Selvy M, Pereira B, Kerckhove N, Gonneau C, Feydel G, Pétorin C, Vimal-Baguet A et al (2020) Long-term prevalence of sensory chemotherapy-induced peripheral neuropathy for 5 years after adjuvant FOLFOX chemotherapy to treat colorectal cancer: a multicenter cross-sectional study. J Clin Med. 9(8):2400. https://doi.org/10.3390/jcm9082400CrossRefPubMedCentral Selvy M, Pereira B, Kerckhove N, Gonneau C, Feydel G, Pétorin C, Vimal-Baguet A et al (2020) Long-term prevalence of sensory chemotherapy-induced peripheral neuropathy for 5 years after adjuvant FOLFOX chemotherapy to treat colorectal cancer: a multicenter cross-sectional study. J Clin Med. 9(8):2400. https://​doi.​org/​10.​3390/​jcm9082400CrossRefPubMedCentral
28.
go back to reference Noble RL (1990) The discovery of the vinca alkaloids–chemotherapeutic agents against cancer. Biochem Cell Biol 68(12):1344–1351CrossRefPubMed Noble RL (1990) The discovery of the vinca alkaloids–chemotherapeutic agents against cancer. Biochem Cell Biol 68(12):1344–1351CrossRefPubMed
43.
45.
go back to reference van de Donk NW, van der Holt B, Minnema MC, Vellenga E, Croockewit S, Kersten MJ, von dem Borne PA et al (2018) Thalidomide before and after autologous stem cell transplantation in recently diagnosed multiple myeloma (HOVON-50): long-term results from the phase 3, randomised controlled trial. Lancet Haematol 5(10):e479–e492. https://doi.org/10.1016/s2352-3026(18)30149-2CrossRefPubMed van de Donk NW, van der Holt B, Minnema MC, Vellenga E, Croockewit S, Kersten MJ, von dem Borne PA et al (2018) Thalidomide before and after autologous stem cell transplantation in recently diagnosed multiple myeloma (HOVON-50): long-term results from the phase 3, randomised controlled trial. Lancet Haematol 5(10):e479–e492. https://​doi.​org/​10.​1016/​s2352-3026(18)30149-2CrossRefPubMed
48.
51.
go back to reference Stork M, Sandecká V, Boichuk I, Adam Z, Krejci M, Brozova L, Sevcikova S et al (2019) Bortezomib and thalidomide treatment results in newly diagnosed transplant-ineligible multiple myeloma patients are comparable in long-term follow-up. Klin Onkol. 32(6):445–52. https://doi.org/10.14735/amko2019445 ((Výsledky léčby bortezomibem a thalidomidem u nově diagnostikovaných netransplantovaných pacientů s mnohočetným myelomem jsou srovnatelné.))CrossRefPubMed Stork M, Sandecká V, Boichuk I, Adam Z, Krejci M, Brozova L, Sevcikova S et al (2019) Bortezomib and thalidomide treatment results in newly diagnosed transplant-ineligible multiple myeloma patients are comparable in long-term follow-up. Klin Onkol. 32(6):445–52. https://​doi.​org/​10.​14735/​amko2019445 ((Výsledky léčby bortezomibem a thalidomidem u nově diagnostikovaných netransplantovaných pacientů s mnohočetným myelomem jsou srovnatelné.))CrossRefPubMed
55.
go back to reference Fanale MA, Whiting NC, Neylon E (2015) Treatment strategies to optimize outcomes with brentuximab vedotin: management of common and rare toxicities. J Target Ther Cancer 4(2):36–45 Fanale MA, Whiting NC, Neylon E (2015) Treatment strategies to optimize outcomes with brentuximab vedotin: management of common and rare toxicities. J Target Ther Cancer 4(2):36–45
56.
go back to reference Moskowitz CH, Nademanee A, Masszi T, Agura E, Holowiecki J, Abidi MH, Chen AI et al (2015) Brentuximab vedotin as consolidation therapy after autologous stem-cell transplantation in patients with Hodgkin’s lymphoma at risk of relapse or progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 385(9980):1853–1862. https://doi.org/10.1016/s0140-6736(15)60165-9CrossRefPubMed Moskowitz CH, Nademanee A, Masszi T, Agura E, Holowiecki J, Abidi MH, Chen AI et al (2015) Brentuximab vedotin as consolidation therapy after autologous stem-cell transplantation in patients with Hodgkin’s lymphoma at risk of relapse or progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 385(9980):1853–1862. https://​doi.​org/​10.​1016/​s0140-6736(15)60165-9CrossRefPubMed
59.
go back to reference Tolaney SM, Tayob N, Dang C, Yardley DA, Isakoff SJ, Valero V, Faggen M et al (2021) Adjuvant trastuzumab emtansine versus paclitaxel in combination with trastuzumab for stage I HER2-positive breast cancer (ATEMPT): a randomized clinical trial. J Clin Oncol 39(21):2375–2385. https://doi.org/10.1200/JCO.20.03398 Tolaney SM, Tayob N, Dang C, Yardley DA, Isakoff SJ, Valero V, Faggen M et al (2021) Adjuvant trastuzumab emtansine versus paclitaxel in combination with trastuzumab for stage I HER2-positive breast cancer (ATEMPT): a randomized clinical trial. J Clin Oncol 39(21):2375–2385. https://​doi.​org/​10.​1200/​JCO.​20.​03398
79.
go back to reference Topp KS, Tanner KD, Levine JD (2000) Damage to the cytoskeleton of large diameter sensory neurons and myelinated axons in vincristine-induced painful peripheral neuropathy in the rat. J Comp Neurol 424(4):563–576CrossRefPubMed Topp KS, Tanner KD, Levine JD (2000) Damage to the cytoskeleton of large diameter sensory neurons and myelinated axons in vincristine-induced painful peripheral neuropathy in the rat. J Comp Neurol 424(4):563–576CrossRefPubMed
94.
96.
106.
go back to reference Savas S, Kim DY, Ahmad MF, Shariff M, Ozcelik H (2004) Identifying functional genetic variants in DNA repair pathway using protein conservation analysis. Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol 13(5):801–807 Savas S, Kim DY, Ahmad MF, Shariff M, Ozcelik H (2004) Identifying functional genetic variants in DNA repair pathway using protein conservation analysis. Cancer Epidemiol Biomarkers Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol 13(5):801–807
110.
116.
go back to reference Apellániz-Ruiz M, Sánchez-Barroso L, Gutiérrez-Gutiérrez G, Sereno M, García-Donás J, Åvall-Lundqvist E, Gréen H et al (2015) Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with paclitaxel–letter. Clin Cancer Res 21(13):3092–3093. https://doi.org/10.1158/1078-0432.Ccr-14-1885CrossRefPubMed Apellániz-Ruiz M, Sánchez-Barroso L, Gutiérrez-Gutiérrez G, Sereno M, García-Donás J, Åvall-Lundqvist E, Gréen H et al (2015) Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with paclitaxel–letter. Clin Cancer Res 21(13):3092–3093. https://​doi.​org/​10.​1158/​1078-0432.​Ccr-14-1885CrossRefPubMed
120.
go back to reference Adjei AA, Lopez CL, Schaid DJ, Sloan JA, Le-Rademacher JG, Loprinzi CL, Norman AD et al (2021) Genetic predictors of chemotherapy-induced peripheral neuropathy from paclitaxel, carboplatin and oxaliplatin: NCCTG/alliance N08C1, N08CA and N08CB study. Cancers (Basel) 13(5):1084. https://doi.org/10.3390/cancers13051084CrossRef Adjei AA, Lopez CL, Schaid DJ, Sloan JA, Le-Rademacher JG, Loprinzi CL, Norman AD et al (2021) Genetic predictors of chemotherapy-induced peripheral neuropathy from paclitaxel, carboplatin and oxaliplatin: NCCTG/alliance N08C1, N08CA and N08CB study. Cancers (Basel) 13(5):1084. https://​doi.​org/​10.​3390/​cancers13051084CrossRef
122.
132.
go back to reference Goldstein D, Von Hoff DD, Moore M, Greeno E, Tortora G, Ramanathan RK, Macarulla T et al (2016) Development of peripheral neuropathy and its association with survival during treatment with nab-paclitaxel plus gemcitabine for patients with metastatic adenocarcinoma of the pancreas: a subset analysis from a randomised phase III trial (MPACT). Eur J Cancer 52:85–91. https://doi.org/10.1016/j.ejca.2015.10.017CrossRefPubMed Goldstein D, Von Hoff DD, Moore M, Greeno E, Tortora G, Ramanathan RK, Macarulla T et al (2016) Development of peripheral neuropathy and its association with survival during treatment with nab-paclitaxel plus gemcitabine for patients with metastatic adenocarcinoma of the pancreas: a subset analysis from a randomised phase III trial (MPACT). Eur J Cancer 52:85–91. https://​doi.​org/​10.​1016/​j.​ejca.​2015.​10.​017CrossRefPubMed
Metadata
Title
Chemotherapy and peripheral neuropathy
Authors
Tiffany Li
David Mizrahi
David Goldstein
Matthew C. Kiernan
Susanna B. Park
Publication date
01-10-2021
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 10/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-021-05576-6

Other articles of this Issue 10/2021

Neurological Sciences 10/2021 Go to the issue