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Supportive Care in Cancer
Published in: Supportive Care in Cancer 10/2019

01-10-2019 | Pharmacokinetics | Review Article

Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview

Authors: Alexandre Chan, Daniel L. Hertz, Manuel Morales, Elizabeth J. Adams, Sharon Gordon, Chia Jie Tan, Nathan P. Staff, Jayesh Kamath, Jeong Oh, Shivani Shinde, Doreen Pon, Niharkia Dixit, James D’Olimpio, Cristina Dumitrescu, Margherita Gobbo, Kord Kober, Samantha Mayo, Linda Pang, Ishwaria Subbiah, Andreas S. Beutler, Katherine B. Peters, Charles Loprinzi, Maryam B. Lustberg

Published in: Supportive Care in Cancer | Issue 10/2019

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Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating condition associated with a number of chemotherapeutic agents. Drugs commonly implicated in the development of CIPN include platinum agents, taxanes, vinca alkaloids, bortezomib, and thalidomide analogues. As a drug response can vary between individuals, it is hypothesized that an individual’s specific genetic variants could impact the regulation of genes involved in drug pharmacokinetics, ion channel functioning, neurotoxicity, and DNA repair, which in turn affect CIPN development and severity. Variations of other molecular markers may also affect the incidence and severity of CIPN. Hence, the objective of this review was to summarize the known biological (molecular and genomic) predictors of CIPN and discuss the means to facilitate progress in this field.
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Metadata
Title
Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview
Authors
Alexandre Chan
Daniel L. Hertz
Manuel Morales
Elizabeth J. Adams
Sharon Gordon
Chia Jie Tan
Nathan P. Staff
Jayesh Kamath
Jeong Oh
Shivani Shinde
Doreen Pon
Niharkia Dixit
James D’Olimpio
Cristina Dumitrescu
Margherita Gobbo
Kord Kober
Samantha Mayo
Linda Pang
Ishwaria Subbiah
Andreas S. Beutler
Katherine B. Peters
Charles Loprinzi
Maryam B. Lustberg
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 10/2019
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-019-04987-8

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