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01-10-2021 | Parkinson's Disease | Original Article

Shear wave elastography characteristics of upper limb muscle in rigidity-dominant Parkinson’s disease

Authors: Chang Wei Ding, Xin Song, Xin Yu Fu, Ying Chun Zhang, Pan Mao, Yu Jing Sheng, Min Yang, Cai Shan Wang, Ying Zhang, Xiao Fang Chen, Cheng Jie Mao, Wei Feng Luo, Chun Feng Liu

Published in: Neurological Sciences | Issue 10/2021

Abstract

Background

Rigidity is one of the major manifestations of Parkinson’s disease (PD), but no quantitative and objective imaging method has been developed to measure rigidity. Ultrasound shear wave elastography (SWE) can reflect the stiffness of tissue by providing a quantitative index. Thus, we conducted this study to evaluate the potential clinical value of SWE in assessing rigidity in PD.

Methods

A total of 63 subjects (44 patients with rigidity-dominant PD and 19 right-dominant-hand normal controls with matched age) were enrolled, and each underwent ultrasound SWE testing. The tests were conducted on the brachioradialis (BR) and biceps brachii (BB) on the more affected side in patients with PD and on the right side in normal controls. Differences in quantitative shear wave velocity (SWV) between patients with PD and normal controls were determined. The relationship of muscle SWV with joint rigidity, UPDRSIII, disease duration, sex, and age in patients with PD was analyzed. The intraclass correlation coefficient (ICC) was used to evaluate the reliability of SWE in assessing muscle stiffness in patients with PD.

Results

The mean SWVs of the BB and BR were higher in the PD group (3.65±0.46 and 4.62±0.89 m/s, respectively) than in normal controls (2.79±0.37 and 3.26±0.40 m/s, respectively). Stiffness in BR and BB was correlated with the upper-limb joint rigidity, UPDRSIII, and disease duration but not with sex or age in the PD group. The intraobserver correlation coefficients (ICCs) for interobserver and intraobserver variations in measuring SWV were 0.85 (95% confidence interval 0.56–0.95) and 0.85 (95% confidence interval 0.58–0.95), respectively, for BR and 0.90 (95% confidence interval 0.73–0.97) and 0.86 (95% confidence interval 0.61–0.95), respectively, for BB.

Conclusions

SWV is associated with joint rigidity and disease duration, indicating that SWE can be potentially used as an objective and quantitative tool for evaluating rigidity.

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Title: Shear wave elastography characteristics of upper limb muscle in rigidity-dominant Parkinson’s disease
Authors: Chang Wei Ding
Xin Song
Xin Yu Fu
Ying Chun Zhang
Pan Mao
Yu Jing Sheng
Min Yang
Cai Shan Wang
Ying Zhang
Xiao Fang Chen
Cheng Jie Mao
Wei Feng Luo
Chun Feng Liu
Publication date: 01-10-2021
Publisher: Springer International Publishing
Keyword: Parkinson's Disease
Published in: Neurological Sciences / Issue 10/2021
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-021-05088-3

At a glance: The STEP trials

Springer Medicine

Shear wave elastography characteristics of upper limb muscle in rigidity-dominant Parkinson’s disease

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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