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13-03-2024 | Hypertension | Original Paper

Aortic regurgitation is associated with African American and Asian race, smoking, renal disease, and numerous autoimmune diseases in addition to traditional cardiovascular risk factors but has lower risk with alcohol intake

Authors: Brandon Timmerman, Mehrtash Hashemzadeh, Mohammad Reza Movahed

Published in: Clinical Research in Cardiology

Abstract

Background

Aortic regurgitation (AR) is associated with increasing age, rheumatic heart disease, and a bicuspid aortic valve, but its association with other comorbidities and race is less known. The purpose of this study was to investigate any association between AR and comorbid conditions in older adults above 40.

Method

The large Nationwide Inpatient Sample database was utilized for our study using uni- and multivariate analysis. Data were extracted from available ICD-10 codes for the years of 2016–2020.

Results

The NIS data included 112,982,565 patients. A total of 660,730 were found to have AR. AR was found to be associated with male gender (OR 1.15, CI 1.14–1.16, P < 0.001), smoking (OR 1.04, CI 1.02–1.05, P < 0.001), hypertension (OR 1.65, CI 1.62–1.68, P < 0.001), hyperlipidemia (OR 1.36, CI 1.34–1.37, P < 0.001), chronic kidney disease (OR 1.22, CI 1.21–1.24, P < 0.001), antiphospholipid antibody syndrome (OR 1.56, CI 1.33–1.83, P < 0.001), rheumatoid arthritis (OR 1.1, CI 1.06–1.14, P < 0.001), scleroderma (OR 1.49, CI 1.31–1.7, P < 0.001), systemic connective tissue disorders (OR 1.32, CI 1.25–1.4, P < 0.001), Raynaud’s syndrome (OR 1.62, CI 1.47–1.77, P < 0.001), and systemic lupus erythematosus (OR 1.44, CI 1.34–1.54, P < 0.001) in add to known bicuspid aortic valve.

Conclusion

Using a very large database, we found new associations between AR and many comorbid conditions, including many inflammatory and chronic degenerative diseases in addition to the known risk factors.

Graphical Abstract

Aortic regurgitation is associated with cardiovascular risk factors, race, and numerous autoimmune diseases.

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Title: Aortic regurgitation is associated with African American and Asian race, smoking, renal disease, and numerous autoimmune diseases in addition to traditional cardiovascular risk factors but has lower risk with alcohol intake
Authors: Brandon Timmerman
Mehrtash Hashemzadeh
Mohammad Reza Movahed
Publication date: 13-03-2024
Publisher: Springer Berlin Heidelberg
Keywords: Hypertension
Hypertension
Systemic Lupus Erythematosus
Obesity
Obesity
Scleroderma
Chronic Kidney Disease
Rheumatoid Arthritis
Published in: Clinical Research in Cardiology
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-024-02424-3

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Aortic regurgitation is associated with African American and Asian race, smoking, renal disease, and numerous autoimmune diseases in addition to traditional cardiovascular risk factors but has lower risk with alcohol intake

Abstract

Background

Method

Results

Conclusion

Graphical Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Method

Results

Conclusion

Graphical Abstract

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ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page