Published in:
18-01-2023 | Heart Failure | Original Paper
Adverse cardiovascular and metabolic perturbations among older women: ‘fat-craving’ hearts
Authors:
Jien Sze Ho, Jie Jun Wong, Fei Gao, Hai Ning Wee, Louis L. Y. Teo, See Hooi Ewe, Ru-San Tan, Jianhong Ching, Kee Voon Chua, Lye Siang Lee, Woon-Puay Koh, Jean-Paul Kovalik, Angela S. Koh
Published in:
Clinical Research in Cardiology
|
Issue 11/2023
Login to get access
Abstract
Background
Despite known sex-based differences in cardiovascular aging, differences in aging biology are poorly understood. We hypothesize that circulating metabolites studied cross-sectionally with cardiac aging may be associated with cardiovascular changes that distinguish cardiac aging in women.
Methods
A population-based cohort of community men and women without cardiovascular disease from Singapore underwent detailed clinical and echocardiography examinations. Cross-sectional associations between cardiac functional characteristics and metabolomics profiles were examined.
Results
Five hundred sixty-seven adults (48.9% women) participated. Women were younger (72 ± 4.4 years vs 73 ± 4.3 years, p = 0.022), had lower diastolic blood pressures (71 ± 11.0 mmHg vs 76 ± 11.2 mmHg, p < 0.0001, and less likely to have diabetes mellitus (18.0% vs 27.6%, p = 0.013) and smoking (3.8% vs 34.5%, p < 0.001). Body mass indices were similar (24 ± 3.8 kg/m2 vs 24 ± 3.4 kg/m2, p = 0.29), but women had smaller waist circumferences (81 ± 10.1 cm vs 85 ± 9.2 cm, p < 0.001). Women had a significantly higher E/e′ ratios (10.9 ± 3.4 vs 9.9 ± 3.3, p = 0.007) and mitral A peak (0.86 ± 0.2 m/s vs 0.79 ± 0.2 m/s, p < 0.001) than men. Among women, lower E/e′ ratio was associated with higher levels of C16 (OR 1.019, 95%CI 1.002–1.036, p = 0.029), C16:1 (OR 1.06, 95%CI 1.006–1.118, p = 0.028), serine (OR 1.019, 95%CI 1.002–1.036, p = 0.025), and histidine (OR 1.045, 95%CI 1.013–1.078, p = 0.006). Lower mitral A peak was associated with higher levels of histidine (OR 1.039, 95%CI 1.009–1.070, p = 0.011), isoleucine (OR 1.013, 95%CI 1.004–1.021, p = 0.004), and C20 (OR 1.341, 95%CI 1.067–1.684, p = 0.012).
Conclusion
Impairments in diastolic functions were more frequent among older women compared to men, despite lower prevalence of vascular risk factors and preserved cardiac structure. Cardiac aging in women correlated with metabolites involved in fatty acid oxidation and tricyclic acid cycle fuelling.