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01-05-2019 | Rhinosinusitis | Review

The role of invariant T cells in inflammation of the skin and airways

Authors: Kwok Ho Yip, Magdalene Papadopoulos, Harshita Pant, Damon J. Tumes

Published in: Seminars in Immunopathology | Issue 3/2019

Abstract

Invariant and semi-invariant T cells are emerging as important regulators of host environment interactions at barrier tissues such as the airway and skin. In contrast to conventional T cells, invariant natural killer T (iNKT) cells and mucosal associated invariant T (MAIT) cells express T cell receptors of very limited diversity. iNKT and MAIT cells recognise antigens presented by the MHC class 1-like monomorphic molecules CD1d and MR1, respectively. Both iNKT cells and MAIT cells have been identified in the skin and airways and can rapidly produce cytokines after activation. Numerous studies have implicated iNKT cells in the pathology of both skin and airway disease, but conflicting evidence in human disease means that more studies are necessary to resolve the exact roles of iNKT in inflammation. The functions of MAIT cells in skin and lung inflammation are even less well defined. We herein describe the current literature on iNKT and MAIT cells in allergic and non-allergic skin diseases (dermatitis and psoriasis) and airway diseases (asthma, chronic obstructive pulmonary disease, rhinitis, and chronic rhinosinusitis).

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Title: The role of invariant T cells in inflammation of the skin and airways
Authors: Kwok Ho Yip
Magdalene Papadopoulos
Harshita Pant
Damon J. Tumes
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keywords: Rhinosinusitis
Bronchial Asthma
Atopic Dermatitis
Vulgar Psoriasis
Cytokines
Published in: Seminars in Immunopathology / Issue 3/2019
Print ISSN: 1863-2297
Electronic ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-019-00740-9

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The role of invariant T cells in inflammation of the skin and airways

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