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Intensive Care Medicine
Published in: Intensive Care Medicine 3/2017

01-03-2017 | Conference Reports and Expert Panel

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Authors: Andrew Rhodes, Laura E. Evans, Waleed Alhazzani, Mitchell M. Levy, Massimo Antonelli, Ricard Ferrer, Anand Kumar, Jonathan E. Sevransky, Charles L. Sprung, Mark E. Nunnally, Bram Rochwerg, Gordon D. Rubenfeld, Derek C. Angus, Djillali Annane, Richard J. Beale, Geoffrey J. Bellinghan, Gordon R. Bernard, Jean-Daniel Chiche, Craig Coopersmith, Daniel P. De Backer, Craig J. French, Seitaro Fujishima, Herwig Gerlach, Jorge Luis Hidalgo, Steven M. Hollenberg, Alan E. Jones, Dilip R. Karnad, Ruth M. Kleinpell, Younsuk Koh, Thiago Costa Lisboa, Flavia R. Machado, John J. Marini, John C. Marshall, John E. Mazuski, Lauralyn A. McIntyre, Anthony S. McLean, Sangeeta Mehta, Rui P. Moreno, John Myburgh, Paolo Navalesi, Osamu Nishida, Tiffany M. Osborn, Anders Perner, Colleen M. Plunkett, Marco Ranieri, Christa A. Schorr, Maureen A. Seckel, Christopher W. Seymour, Lisa Shieh, Khalid A. Shukri, Steven Q. Simpson, Mervyn Singer, B. Taylor Thompson, Sean R. Townsend, Thomas Van der Poll, Jean-Louis Vincent, W. Joost Wiersinga, Janice L. Zimmerman, R. Phillip Dellinger

Published in: Intensive Care Medicine | Issue 3/2017

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Abstract

Objective

To provide an update to “Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012”.

Design

A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015. Teleconferences and electronic-based discussion among subgroups and among the entire committee served as an integral part of the development.

Methods

The panel consisted of five sections: hemodynamics, infection, adjunctive therapies, metabolic, and ventilation. Population, intervention, comparison, and outcomes (PICO) questions were reviewed and updated as needed, and evidence profiles were generated. Each subgroup generated a list of questions, searched for best available evidence, and then followed the principles of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence from high to very low, and to formulate recommendations as strong or weak, or best practice statement when applicable.

Results

The Surviving Sepsis Guideline panel provided 93 statements on early management and resuscitation of patients with sepsis or septic shock. Overall, 32 were strong recommendations, 39 were weak recommendations, and 18 were best-practice statements. No recommendation was provided for four questions.

Conclusions

Substantial agreement exists among a large cohort of international experts regarding many strong recommendations for the best care of patients with sepsis. Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Appendix
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Metadata
Title
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Authors
Andrew Rhodes
Laura E. Evans
Waleed Alhazzani
Mitchell M. Levy
Massimo Antonelli
Ricard Ferrer
Anand Kumar
Jonathan E. Sevransky
Charles L. Sprung
Mark E. Nunnally
Bram Rochwerg
Gordon D. Rubenfeld
Derek C. Angus
Djillali Annane
Richard J. Beale
Geoffrey J. Bellinghan
Gordon R. Bernard
Jean-Daniel Chiche
Craig Coopersmith
Daniel P. De Backer
Craig J. French
Seitaro Fujishima
Herwig Gerlach
Jorge Luis Hidalgo
Steven M. Hollenberg
Alan E. Jones
Dilip R. Karnad
Ruth M. Kleinpell
Younsuk Koh
Thiago Costa Lisboa
Flavia R. Machado
John J. Marini
John C. Marshall
John E. Mazuski
Lauralyn A. McIntyre
Anthony S. McLean
Sangeeta Mehta
Rui P. Moreno
John Myburgh
Paolo Navalesi
Osamu Nishida
Tiffany M. Osborn
Anders Perner
Colleen M. Plunkett
Marco Ranieri
Christa A. Schorr
Maureen A. Seckel
Christopher W. Seymour
Lisa Shieh
Khalid A. Shukri
Steven Q. Simpson
Mervyn Singer
B. Taylor Thompson
Sean R. Townsend
Thomas Van der Poll
Jean-Louis Vincent
W. Joost Wiersinga
Janice L. Zimmerman
R. Phillip Dellinger
Publication date
01-03-2017
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 3/2017
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-017-4683-6

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