Published in:
01-06-2013 | Guideline
Practice guidelines for therapeutic drug monitoring of vancomycin: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring
Authors:
Kazuaki Matsumoto, Yoshio Takesue, Norio Ohmagari, Takahiro Mochizuki, Hiroshige Mikamo, Masafumi Seki, Shunji Takakura, Issei Tokimatsu, Yoshiko Takahashi, Kei Kasahara, Kenji Okada, Masahiro Igarashi, Masahiro Kobayashi, Yukihiro Hamada, Masao Kimura, Yoshifumi Nishi, Yusuke Tanigawara, Toshimi Kimura
Published in:
Journal of Infection and Chemotherapy
|
Issue 3/2013
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Excerpt
Vancomycin (VCM) is a glycopeptide antibiotic that was introduced in Japan in November 1991. VCM is widely used for the treatment of invasive multi-resistant gram-positive bacterial infections, particularly those involving methicillin-resistant
Staphylococcus aureus (MRSA) [
1‐
5]. VCM use is associated with adverse events, including "red man syndrome" [
6], nephrotoxicity [
7‐
9], and ototoxicity [
10,
11]. Compared with other antimicrobial agents, the therapeutic range is narrow in VCM, and therapeutic drug monitoring (TDM) is required for maximizing efficacy while minimizing the onset of these toxicities [
12‐
14]. …