Hepatocellular carcinoma (HCC), a common and deadly form of liver cancer, is the second primary cause of cancer-related death globally [ 1 ]. Advances in diagnosis and treatment have been made, yet patients’ prognoses remain discouraging …
Combined hepatocellular–cholangiocarcinoma (cHCC–CCA) is a rare type of primary liver cancer (PLC) characterized by both hepatocellular and biliary epithelial phenotypes and has an incidence that varies between 0.4% and 14.2% [ 1 ]. cHCC–CCA, as a …
Authors:
Wenchen Gong, Su Zhang, Xiangdong Tian, Wenshuai Chen, Yuchao He, Liwei Chen, Tingting Ding, Peiqi Ren, Lin Shi, Qiang Wu, Yan Sun, Lu Chen, Hua Guo
Among patients with compensated advanced chronic liver disease (cACLD), the occurrence of portal hypertension takes main responsibility for severe clinical consequence, such as variceal hemorrhage, ascites, hepatic encephalopathy [ 1 , 2 ]. To …
Authors:
Ruiling He, Chuan Liu, Ivica Grgurevic, Ying Guo, Huixiong Xu, Jiacheng Liu, Yunfang Liu, XiaoYan Wang, Hongmei Shi, Anita Madir, Kristian Podrug, Yuli Zhu, Yongli Hua, Kun Wang, Jing Wen, Meiqin Su, Qun Zhang, Jie Li, Xiaolong Qi
Primary liver cancer (PLC) is the sixth most common cancer worldwide and the third most common cause of cancer death, with hepatocellular carcinoma (HCC) accounting for about 85% of all PLC [ 1 ]. Despite the rapid advancements in medical …
Authors:
He Li, Lingzhan Meng, Simiao Yu, Haocheng Zheng, Lingxiang Yu, Hongbo Wang, Hui Ren, Hu Li, Xiaofeng Zhang, Zizheng Wang, Peng Yu, Xiongwei Hu, Muyi Yang, Jin Yan, Yanling Shao, Li Cao, Xia Ding, Zhixian Hong, Zhenyu Zhu
Acute variceal bleeding is one of the major cause of mortality in patients with cirrhosis. Variceal hemorrhage occurs at a yearly rate of 5–15%, and the most important predictor of hemorrhage is the large size of varices, decompensated cirrhosis …
Authors:
Abhijeet Ranjan, Ankur Jindal, Rakhi Maiwall, Chitranshu Vashishtha, Rajan Vijayaraghavan, Vinod Arora, Shiv K. Sarin
Open Access
08-05-2024 | Fatty Liver | Special supplement : MAFLD
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver disease worldwide with most recent estimates as high as 39% in adults and 20% in children [ 1 , 2 ]. Characterised by hepatic steatosis in the setting of …
Authors:
Shelley E. Keating, Yogesh Chawla, Arka De, Elena S. George
Fatty liver disease, which is linked to metabolic dysfunction, is a prevalent condition affecting around 30% of adults worldwide [ 1 , 2 ]. After 3 years of debate and uncertainty about the need to update the definition of disease, there is now a …
Authors:
Ziyan Pan, Said A. Al-Busafi, Maheeba Abdulla, Yasser Fouad, Giada Sebastiani, Mohammed Eslam
Hepatocellular carcinoma (HCC) is a prominent contributor to malignancy-related fatalities worldwide, the tumor occurrence and progression are frequently accompanied by the simultaneous presence of tricky sequelae [ 1 ]. Portal vein tumor …
Acute kidney injury (AKI) and liver injury are two common complications among hospitalized patients [ 1 , 2 ]. AKI is characterized by an abrupt decrease in kidney function that leads to dysregulation of homeostasis and is associated with higher …
Authors:
Yuxin Lin, Pingping Li, Yuping Zhang, Qi Gao, Licong Su, Yanqin Li, Ruqi Xu, Yue Cao, Peiyan Gao, Fan Luo, Ruixuan Chen, Xiaodong Zhang, Sheng Nie, Xin Xu, for the CRDS Study Investigators
Bacterial infections, notably spontaneous bacterial peritonitis (SBP), are observed in 40–70% of cirrhosis patients and have a potentially significant impact on the progression of liver failure, development of liver-related complications, and …
Authors:
Jie Han, Fei-li Wei, Hao-xin Wu, Lu-yao Guo, Shan Guo, Ying Han, Ya-nan Sun, Wei Hou, Zhong-jie Hu
We read Ng KT’s paper [ 1 ] with great interest. This study investigated the prognostic value of post-transplant cytokines on tumor recurrence after liver transplantation (LT) for hepatocellular carcinoma (HCC). A prediction model for post-LT tumor …
Portal hypertension (PH) is a significant complication in patients with chronic advanced liver disease, leading to the development of esophageal varices (EVs), ascites, hepatic encephalopathy (HE), and hepatorenal syndrome (HRS), which contribute …
Authors:
Mauro Giuffrè, Johannes Dupont, Alessia Visintin, Flora Masutti, Fabio Monica, Kisung You, Dennis L. Shung, Lory Saveria Crocè, The NSBB-Elasto-Response-Prediction Group
Open Access
25-04-2024 | Epigenetics | Special supplement: MAFLD
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver disease worldwide. The risk of developing MAFLD varies among individuals, due to a combination of environmental inherited and acquired genetic factors.
Authors:
Vittoria Moretti, Stefano Romeo, Luca Valenti
Open Access
16-04-2024 | Biomarkers | Original Article
Although hepatic tumors rarely occur during childhood, they are associated with significantly higher morbidity and mortality in affected patients. Hepatoblastoma (HB) is the most common malignant hepatic tumor in children under the age of 3 years …
Authors:
Hongxiang Gao, Chenjie Xie, Jing Wang, Ji Ma, Shijian Liu, Li Xie, Yijie Zheng, Rui Dong, Shan Wang, Yongjun Fang, Yurui Wu, Xianwei Zhang, Xianying Lu, Yang Li, Weisong Li, Qiuhui Pan, Min Xu, Song Gu
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. In recent years, a new terminology and definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed. Compared to …
Authors:
Jing Zhao, Lu Liu, Ying-Ying Cao, Xin Gao, Giovanni Targher, Christopher D. Byrne, Dan-Qin Sun, Ming-Hua Zheng
Acute-on-chronic liver failure (ACLF) is a syndrome that is characterized by the rapid development of organ failures predisposing these patients to a high risk of short-term early death. The main causes of organ failure in these patients are …
Authors:
Rakhi Maiwall, Satender Pal Singh, Paolo Angeli, Richard Moreau, Aleksander Krag, Virender Singh, Ashwani K. Singal, S. S. Tan, Puneet Puri, Mamun Mahtab, George Lau, Qin Ning, Manoj Kumar Sharma, P. N. Rao, Dharmesh Kapoor, Subhash Gupta, Ajay Duseja, Manav Wadhawan, Dinesh Jothimani, Sanjiv Saigal, Sunil Taneja, Akash Shukla, Pankaj Puri, Deepak Govil, Gaurav Pandey, Kaushal Madan, C. E. Eapen, Jaya Benjamin, Ashok Chowdhury, Shweta Singh, Vaishali Salao, Jin Mo Yang, Saeed Hamid, Shalimar, Sanjiv Jasuja, Anand V. Kulkarni, Madund A. Niriella, Harsh Vardhan Tevethia, Vinod Arora, R. P. Mathur, Akash Roy, Ankur Jindal, Neeraj Saraf, Nipun Verma, Arka De, Narendra S. Choudhary, Rohit Mehtani, Phool Chand, Omkar Rudra, Shiv Kumar Sarin
Liver fibrosis and cirrhosis in chronic hepatitis B (CHB) patients are now considered to be reversible following sustained antiviral treatment as demonstrated by several clinical studies based on both short- and long-term antiviral treatment [ 1 – …
