Regarding the role of post-transplant inflammatory cytokine signature on predicting tumor recurrence after liver transplantation for hepatocellular carcinoma

Excerpt

We read Ng KT’s paper [1] with great interest. This study investigated the prognostic value of post-transplant cytokines on tumor recurrence after liver transplantation (LT) for hepatocellular carcinoma (HCC). A prediction model for post-LT tumor recurrence was generated by the logistic regression. They found that the P3C-UCSF-AFP score significantly predicted post-LT tumor recurrence and poor survival, and the P3C-UCSF-AFP score was validated to significantly predict post-LT 2-year and 5-year tumor recurrence. Finally, they concluded that the integrated P3C-UCSF-AFP score can predict post-LT tumor recurrence accurately. However, in this letter, we raise some statistical concerns about this study which may change the result of this study. …