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Investigational New Drugs

Issue 1/2024

Content (15 Articles)

Immunoneoadjuvant therapy with immune checkpoint inhibitors of gastric cancer: an emerging exemplification

Guoliang Yao, Jianyong Yuan, Qianqian Duan, Yuan Tan, Qin Zhang, Dongsheng Chen, Jingbo Chen

Open Access Hepatocellular Carcinoma Research

Phase I/II trial of BMS-986,205 and nivolumab as first line therapy in hepatocellular carcinoma

Jasmine C. Huynh, May Cho, Arta Monjazeb, Ebaa Al-Obeidi, Amisha Singh, Kit Tam, Frances Lara, Anthony Martinez, Leslie Garcia, Edward J. Kim

Olanzapine Research

A multicenter phase II trial of the triplet antiemetic therapy with palonosetron, aprepitant, and olanzapine for a cisplatin-containing regimen. - PATROL-I-

Daiki Tsuji, Shigeru Nakagaki, Itsuki Yonezawa, Kenichi Suzuki, Takashi Yokokawa, Yohei Kawasaki, Takumi Yamaguchi, Takashi Kawaguchi, Masahiro Hatori, Takuma Matsumoto, Yukio Sakata, Keisuke Yamamoto, Tomoyasu Nishimura, Yuki Kogure, Toshinobu Hayashi, Misa Osawa, Kunihiko Itoh, Masaya Watanabe

Melanoma Research

RPTOR mutation: a novel predictor of efficacious immunotherapy in melanoma

Yanfang Jiang, Xintong Hu, Zhouyu Wang, Qin Zhang, Dongsheng Chen, Pingwei Zhao

Open Access Pharmacokinetics Research

Effects of food and ethnicity on the pharmacokinetics of venadaparib, a next-generation PARP inhibitor, in healthy Korean, Caucasian, and Chinese male subjects

Hyun Chul Kim, Eunsol Yang, Soyoung Lee, Jaeseong Oh, Myongjae Lee, ChaeEun Lee, Kyoung Soo Ha, Won Sik Lee, In-Jin Jang, Kyung-Sang Yu

Research

Targeted delivery of liposomal Ribociclib to SLC7A5 transporters in breast cancer cells

Mahtab Afsharzadeh, Jaleh Varshosaz, Mina Mirian, Farshid Hasanzadeh

Myocarditis Research

Clinical characteristics, diagnosis and management of nivolumab-induced myocarditis

Meng-Ting Li, Yang He, Si-Yong Huang, Xiao Hu, Ji-Sheng Chen

Sorafenib Research

Phase 1 trial of navitoclax and sorafenib in patients with relapsed or refractory solid tumors with hepatocellular carcinoma expansion cohort

Oluwadunni E. Emiloju, Jun Yin, Emily Koubek, Joel M. Reid, Mitesh J. Borad, Yanyan Lou, Mahesh Seetharam, Martin J. Edelman, Edward A. Sausville, Yixing Jiang, Ahmed O. Kaseb, James A. Posey, Sarah L. Davis, Gregory J. Gores, Lewis R. Roberts, Naoko Takebe, Gary K. Schwartz, Andrea E. Wahner Hendrickson, Scott H. Kaufmann, Alex A. Adjei, Joleen M. Hubbard, Brian A. Costello

Open Access SCLC Research

Phase 1 study of pembrolizumab plus chemotherapy in Japanese patients with extensive-stage small-cell lung cancer

Naoyuki Nogami, Takaaki Tokito, Yoshitaka Zenke, Miyako Satouchi, Takashi Seto, Hideo Saka, Junko Ohtani, Shirong Han, Kazuo Noguchi, Makoto Nishio

Open Access Research

CXCR2 antagonist navarixin in combination with pembrolizumab in select advanced solid tumors: a phase 2 randomized trial

Andrew J. Armstrong, Ravit Geva, Hyun Cheol Chung, Charlotte Lemech, Wilson H. Miller Jr., Aaron R. Hansen, Jong-Seok Lee, Frank Tsai, Benjamin J. Solomon, Tae Min Kim, Christian Rolfo, Vincent Giranda, Yixin Ren, Fang Liu, Bhargava Kandala, Tomoko Freshwater, Judy S. Wang

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine