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Investigational New Drugs

Issue 4/2023

Content (10 Articles)

Degradation of MYC by the mutant p53 reactivator drug, COTI-2 in breast cancer cells

Minhong Tang, John Crown, Michael J Duffy

A phase I/II study of LY3022855 with BRAF/MEK inhibition in patients with Melanoma

Elizabeth I. Buchbinder, Anita Giobbie-Hurder, Rizwan Haq, Patrick A. Ott

POTEE mutation as a potential predictive biomarker for immune checkpoint inhibitors in lung adenocarcinoma

Yongzhao Li, Qidong Yang, Yaqin Liu, Huan Yi, Yongzhi Ju, Guoyan Qi

Sitravatinib is a potential EGFR inhibitor and induce a new death phenotype in Glioblastoma

Hanwen Lu, Bingchang Zhang, Yuanyuan Xie, Wenpeng Zhao, Wanhong Han, Liwei Zhou, Zhanxiang Wang

Assessment of the potential of the MET inhibitor tepotinib to affect the pharmacokinetics of CYP3A4 and P-gp substrates

Özkan Yalkinoglu, Andreas Becker, Axel Krebs-Brown, Claudia Vetter, Christian Lüpfert, Dominique Perrin, Jürgen Heuer, Herlind Biedert, Stefan Hirt, Afrim Bytyqi, Angelika Bachmann, Rainer Strotmann

Indirect comparisons of efficacy of zanubrutinib versus orelabrutinib in patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma or relapsed or refractory mantle cell lymphoma

Yuqin Song, Keshu Zhou, Shenmiao Yang, Jianda Hu, Dehui Zou, Sujun Gao, Ling Pan, Tingyu Wang, Haiyan Yang, Huilai Zhang, Daobin Zhou, Jie Ji, Wei Xu, Ru Feng, Jie Jin, Fangfang Lv, Haiwen Huang, Xiaosi Fan, Sheng Xu, Jun Zhu

Correction to: The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma

Guihong Liu, Yachun Lu, Liantao Li, Tao Jiang, Sufang Chu, Pingfu Hou, Jin Bai, Ming Chen

Women’s health knowledge hub

Elevate your patient care with our comprehensive, evidence-based medical education on women's health. Designed to help you provide exceptional care for your female patients at every stage of life, we provide expert insights into topics such as reproductive health, menopause, breast cancer and sex-specific health risks and precision medicine.

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Incorporating comprehensive genomic profiling into the standard-of-care for NSCLC and thyroid cancer

In this interactive webinar, experts Dr. Subbiah, Dr. Drilon, and Dr. Williams discuss best pathological practices within NSCLC and thyroid cancer, as well as how genomic testing can improve outcomes in clinical practice, using patient case studies as illustrations.

This content is intended only for US-based healthcare providers.

Supported by:
  • Illumina, Inc., and Eli Lilly and Company
Dr. Vivek Subbiah
Dr. Alexander Drilon
Dr. Michelle Williams
Developed by: Springer Healthcare
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Video

Elevate your expertise in aplastic anemia (Link opens in a new window)

Transform the way you care for your patients with aplastic anemia with our 3-module series using real-world case studies and expert insights. Discover why early diagnosis matters, explore the benefits and risks of current treatments, and develop tailored approaches for complex cases. 

Supported by:
  • Pfizer
Developed by: Springer Healthcare IME
Learn more