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Published in: Virology Journal 1/2019

Open Access 01-12-2019 | Hepatitis B | Review

The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis

Authors: Fanyun Kong, Hongjuan You, Delong Kong, Kuiyang Zheng, Renxian Tang

Published in: Virology Journal | Issue 1/2019

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Abstract

Background

The ubiquitin proteasome system (UPS) regulates the expression levels of cellular proteins by ubiquitination of protein substrates followed by their degradation via the proteasome. As a highly conserved cellular degradation mechanism, the UPS affects a variety of biological processes and participates in viral propagation.

Main body

During hepatitis B virus (HBV) infection, the UPS is shown to act as a double-edged sword in viral pathogenesis. On the one hand, the UPS acts as a host defense mechanism to selectively recognize HBV proteins as well as special cellular proteins that favor the viral life cycle and induces their ubiquitin-dependent proteasomal degradation to limit HBV infection. On the other hand, the HBV has evolved to subvert the UPS function for its own advantage. Moreover, in the infected hepatocytes, certain cellular proteins that are dependent on the UPS are involved in abnormal biological processes which are mediated by HBV.

Conclusion

The molecular interaction of HBV with the UPS to modulate viral propagation and pathogenesis is summarized in the review. Considering the important role of the UPS in HBV infection, a better understanding of the HBV-UPS interaction could provide novel insight into the mechanisms that are involved in viral replication and pathogenesis and help to develop potential treatment strategies targeting the UPS.
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Metadata
Title
The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis
Authors
Fanyun Kong
Hongjuan You
Delong Kong
Kuiyang Zheng
Renxian Tang
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2019
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-019-1183-z

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