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Diabetology

Editor's Choice

GLP-1 RAs may reduce dementia risk

Glucose lowering with GLP-1 receptor agonists may reduce the risk for dementia in patients with type 2 diabetes.

GLP-1 RA plus thiazolidinedione has CV benefits in type 2 diabetes

Combination therapy with a GLP-1 receptor agonist plus thiazolidinedione significantly reduces the risk for major adverse CV events and death versus nonuse in people with type 2 diabetes.

Colonic ischemia associated with a GLP-1 RA

Although it seems to be a rare complication, there should be a high index of suspicion for colonic ischemia in patients taking a GLP-1 receptor agonist who present with abdominal pain.

Focus on insulin icodec

A thorough overview of the safety and efficacy of once-weekly basal insulin icodec in type 1 and 2 diabetes, covering pharmacology, pharmacokinetics, adverse effects, drug interactions, and dose recommendations.

STRIDEs made for type 2 diabetes plus peripheral artery disease

Semaglutide increases walking capacity and improves symptoms and quality of life versus placebo in people with type 2 diabetes and peripheral artery disease.

Continuous ranibizumab delivery system beneficial in diabetic eye disease

Continuous ranibizumab treatment delivered via the Port Delivery System is comparable to monthly injections for improving vision in patients with diabetic eye disease.

The promise of incretin-based therapies for MASH

Discover the growing evidence for incretin-based therapies in metabolic dysfunction-associated steatohepatitis, the potential mechanisms involved, common side effects, and what’s needed to finesse their use.

CV efficacy of oral semaglutide confirmed for high-risk type 2 diabetes

Oral semaglutide significantly reduces the risk for major adverse cardiovascular events versus placebo in people with high-risk type 2 diabetes.

Personalized dapagliflozin needed for type 2 diabetes and CKD

Dapagliflozin significantly reduces the urine albumin-to-creatinine ratio versus placebo in people with type 2 diabetes and chronic kidney disease, but the magnitude of the effect varies per person.

Exploring the shared genetic landscape of diabetes and CVD

Discover the genetic risk loci that influence both type 2 diabetes and CVD, and how disease-specific subtyping approaches may help reduce the burden of multimorbidity in type 2 diabetes.

Early weight loss increases chance of type 2 diabetes remission

Weight loss of 10% or more within 5 years of type 2 diabetes diagnosis improves HbA1c and cardiometabolic parameters, and increases remission rates versus less weight loss.

Non-islet cell tumor hypoglycemia and sarcoma

NICTH was diagnosed in a man with pelvic sarcoma. Severe hypoglycemia did not respond to standard treatments but had a partial response to rhGH and angioembolization of the tumor.

Combining SGLT2is, GLP-1 RAs, and nsMRAs in diabetes

Combination therapy is a cornerstone of type 2 diabetes management, but what’s known about the effects of combining SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal MRAs?

Sleep health important after gestational diabetes

Shorter sleep duration and both regular and occasional snoring are linked to an increased risk for type 2 diabetes in women with a history of gestational diabetes.

Advances in assessing myocardial microcirculation in diabetes

Imaging techniques are enhancing our understanding of the myocardial microcirculation and providing insights into the early stages of microvascular dysfunction in people with diabetes.

Modest increase in NAION risk with semaglutide

Increased risk for nonarteritic anterior ischemic optic neuropathy associated with semaglutide treatment in people with type 2 diabetes is not as great as previously reported.

Novel berberine-based treatment for type 2 diabetes

Berberine ursodeoxycholate, a gut–liver anti-inflammatory metabolic modulator, significantly reduces HbA1c and improves hepatic and cardiometabolic parameters in people with type 2 diabetes.

Minimizing glycemic variability in type 1 diabetes

Recommendations proposed to reduce glycemic variability and improve glycemic management in people with type 1 diabetes, focusing on physical activity, dietary habits, insulin therapy, and other causes of increased variability.

Delayed diagnosis of monogenic diabetes

Complete heterozygous deletion of HNF1B was incidentally discovered in a woman who was enrolled in a clinical trial for type 1 diabetes and received immunosuppressive treatment for 4 years when she was a child.

Increasing muscle mass and strength in type 2 diabetes

Obesity treatments can cause a large decline in muscle mass. How can this be addressed in people with type 2 diabetes who already experience accelerated loss of muscle mass and function?