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16-02-2023 | Cranial MRI | Case Report

Successful treatment of HIV-associated progressive multifocal leukoencephalopathy (PML) with mirtazapine, mefloquine, and IVIG combination therapy: a case report

Authors: Beyza Cifci, Yesim Yildiz, Emine Altin, Hamid Habibi, Belgin Kocer, Murat Dizbay

Published in: Journal of NeuroVirology | Issue 1/2023

Abstract

Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by reactivation of the polyomavirus JC (JCV). Human immunodeficiency virus (HIV) infection is one of the leading causes of PML which has high morbidity and mortality due to the lack of a proven standard treatment. We found clinical and radiological improvement with the combination of high-dose methylprednisolone, mirtazapine, mefloquine, and IVIG in our patient who presented with neurological symptoms and had diagnosed concurrent acquired immunodeficiency syndrome (AIDS) and PML. To our knowledge, our case is the first HIV-associated PML which responded to this combination therapy.

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Title: Successful treatment of HIV-associated progressive multifocal leukoencephalopathy (PML) with mirtazapine, mefloquine, and IVIG combination therapy: a case report
Authors: Beyza Cifci
Yesim Yildiz
Emine Altin
Hamid Habibi
Belgin Kocer
Murat Dizbay
Publication date: 16-02-2023
Publisher: Springer International Publishing
Keywords: Cranial MRI
Mefloquine
Immunodeficiency
Demyelinating Disease
Human Immunodeficiency Virus
Mirtazapine
Mirtazapine
Published in: Journal of NeuroVirology / Issue 1/2023
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-023-01114-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Successful treatment of HIV-associated progressive multifocal leukoencephalopathy (PML) with mirtazapine, mefloquine, and IVIG combination therapy: a case report

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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