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01-02-2017 | Short Communication

JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7

Authors: David N. Soleimani-Meigooni, Katherine E. Schwetye, Maria Reyes Angeles, Caroline F. Ryschkewitsch, Eugene O. Major, Xin Dang, Igor J. Koralnik, Robert E. Schmidt, David B. Clifford, F. Matthew Kuhlmann, Robert C. Bucelli

Published in: Journal of NeuroVirology | Issue 1/2017

Abstract

JC virus (JCV) is a human polyomavirus that infects the central nervous system (CNS) of immunocompromised patients. JCV granule cell neuronopathy (JCV-GCN) is caused by infection of cerebellar granule cells, causing ataxia. A 77-year-old man with iatrogenic lymphopenia presented with severe ataxia and was diagnosed with JCV-GCN. His ataxia and cerebrospinal fluid (CSF) improved with intravenous immunoglobulin, high-dose intravenous methylprednisolone, mirtazapine, and mefloquine. Interleukin-7 (IL-7) therapy reconstituted his lymphocytes and reduced his CSF JCV load. One month after IL-7 therapy, he developed worsening ataxia and CSF inflammation, which raised suspicion for immune reconstitution inflammatory syndrome. Steroids were restarted and his ataxia stabilized.

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Title: JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7
Authors: David N. Soleimani-Meigooni
Katherine E. Schwetye
Maria Reyes Angeles
Caroline F. Ryschkewitsch
Eugene O. Major
Xin Dang
Igor J. Koralnik
Robert E. Schmidt
David B. Clifford
F. Matthew Kuhlmann
Robert C. Bucelli
Publication date: 01-02-2017
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 1/2017
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-016-0465-0

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JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7

Abstract

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