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Immunodeficiency 

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  1. Open Access 01-12-2024 | Human Immunodeficiency Virus | OriginalPaper

    Effectiveness of human immunodeficiency virus prevention strategies by mapping the geographic dispersion pattern of human immunodeficiency virus prevalence in Nanning, China

    Human immunodeficiency virus (HIV) infection is a global health concern. Globally, the number of people living with HIV was 37.7 million, with 1.5 million people newly infected with HIV, in 2020 [ 1 ]. This suggests continued HIV transmission …

  2. Open Access 01-06-2024 | Immunodeficiency | OriginalPaper

    Treatment with Elapegademase Restores Immunity in Infants with Adenosine Deaminase Deficient Severe Combined Immunodeficiency

    Adenosine deaminase 1 (ADA) deficiency is an autosomal recessive disorder of purine metabolism resulting in elevated levels of adenosine (Ado) and deoxyadenosine (dAdo) in plasma and urine [ 1 , 2 ]. The accumulation of intracellular dAdo …

  3. Open Access 01-03-2024 | Primary Immunodeficiency | OriginalPaper

    Psychosocial Evaluation of Adults with Primary Immunodeficiency

    Primary immunodeficiency (PID) may manifest as recurrent, severe, atypical infections or autoimmunity, lymphoproliferation, or malignancies at diagnosis or during the course of the disease. There are many different types of PIDs, ranging from …

  4. 01-06-2024 | Thymectomy | OriginalPaper

    Immunological Aspects of Kabuki Syndrome: A Retrospective Multicenter Study of the Italian Primary Immunodeficiency Network (IPINet)

    Kabuki Syndrome (KS) is a multisystemic genetic disorder. A portion of patients has immunological manifestations characterized by increased susceptibility to infections and autoimmunity. Aiming to describe the clinical and laboratory immunological …

  5. 30-04-2024 | Stem Cell Transplantation | Online First

    Survival After Hematopoietic Stem Cell Transplantation in Severe Combined Immunodeficiency (SCID): A Worldwide Review of the Prognostic Variables

    This study aims to perform an extensive review of the literature that evaluates various factors that affect the survival rates of patients with severe combined immunodeficiency (SCID) after hematopoietic stem cell transplantation (HSCT) in …

  6. Open Access 25-04-2024 | Telemedicine | Online First

    The Impact of Telemedicine on Human Immunodeficiency Virus (HIV)-Related Clinical Outcomes During the COVID-19 Pandemic

    The coronavirus disease of 2019 (COVID-19) pandemic exacerbated barriers to care for people living with human immunodeficiency virus (HIV) (PLWH). The quick uptake of telemedicine in the outpatient setting provided promise for care continuity. In …

  7. Open Access 01-12-2024 | Epilepsy | OriginalPaper

    Improvement of epilepsy secondary to acquired immunodeficiency syndrome with intestinal microbiota preparations: a case report

    Acquired immunodeficiency syndrome (AIDS) is a severe infectious disease caused by human immunodeficiency virus (HIV) infection, which primarily impairs the immune system and leads to cumulative damage in multiple systems. Epilepsy is highly …

  8. Open Access 01-12-2024 | Human Immunodeficiency Virus | OriginalPaper

    The association between single-nucleotide polymorphisms within type 1 interferon pathway genes and human immunodeficiency virus type 1 viral load in antiretroviral-naïve participants

    Disease progression among antiretroviral treatment (ART) naïve people living with HIV (PLWH) differs substantially [ 1 ], with both viral and host genetic factors (and their interaction) known to play an important role [ 2 – 4 ]. Human leukocyte …

  9. Open Access 01-12-2024 | Human Immunodeficiency Virus | OriginalPaper

    Clinical outcomes of liver transplantation in human immunodeficiency virus/hepatitis B virus coinfected patients in China

    Highly active antiretroviral therapy (HAART), introduced in 1996, has significantly improved the survival of patients infected with the human immunodeficiency virus (HIV) [ 1 ]. It is well-established that HAART can suppress HIV replication …

  10. Open Access 01-12-2024 | Human Immunodeficiency Virus | OriginalPaper

    Mortality and its predictors among human immunodeficiency virus-infected children younger than 15 years receiving antiretroviral therapy in Ethiopia: a systematic review and meta-analysis

    By the end of 2022, an estimated 39 million people were living with the human immunodeficiency virus (HIV) (1.5 million of whom were children younger than 15 years of age), and an estimated 630,000 people died from HIV-related causes [ 1 ].

  11. Open Access 06-04-2024 | Human Immunodeficiency Virus | Online First

    Perceptions and Acceptance of a Prophylactic Vaccine for Human Immunodeficiency Virus (HIV): A Qualitative Study

    Human immunodeficiency virus (HIV) is a retrovirus that attacks the body’s immune system, thus weakening the body against other infections and illnesses. When left untreated, HIV progresses to acquired immune deficiency syndrome (AIDS), a …

  12. 10-05-2024 | Online First

    A Study on Perceptions of Undetectable = Untransmittable Among Gay Men with Human Immunodeficiency Virus in the HIV Community on Twitter in Japan: An Exploratory Qualitative Study Using a Modified Grounded Theory Approach

    This study explores the perceptions of the Undetectable = Untransmittable (U = U) campaign among gay men with HIV in Japan who are part of the HIV community on Twitter. We conducted detailed semistructured interviews with 12 participants using a …

  13. Open Access 01-02-2024 | Immunodeficiency | Erratum

    Correction to: Reduced neuronal population in the dorsolateral prefrontal cortex in infant macaques infected with simian immunodeficiency virus (SIV)

  14. Open Access 01-12-2024 | Human Immunodeficiency Virus | OriginalPaper

    Diffuse myocardial fibrosis is uncommon in people with perinatally acquired human immunodeficiency virus infection

    Despite increased life expectancy with widespread use of antiretroviral therapy (ART), cardiovascular disease (CVD) remains a leading cause of mortality in people living with human immunodeficiency virus (PLWH) [ 1 , 2 ]. Current data suggests that …

  15. Open Access 01-12-2024 | Human Immunodeficiency Virus | OriginalPaper

    Neuroinflammation driven by human immunodeficiency virus-1 (HIV-1) directs the expression of long noncoding RNA RP11-677M14.2 resulting in dysregulation of neurogranin in vivo and in vitro

    Neuroinflammation and synaptodendritic damage represent the pathological hallmarks of HIV-1 associated cognitive disorders (HAND). The post-synaptic protein neurogranin (Nrgn) is significantly reduced in the frontal cortex of postmortem brains …

  16. 20-01-2024 | Human Immunodeficiency Virus | ReviewPaper

    Major Drug Resistance Mutations on Reverse Transcriptase Gene in Human Immunodeficiency Virus Type-1 in Indonesia: A Systematic Review

    In low- and middle-income nations, including Indonesia, the HIV/AIDS epidemic continues to be regarded as a major public health burden. The number of HIV-positive adults and children in Indonesia is estimated to be 540,000 [ 1 ]. Given that …

  17. Open Access 01-12-2024 | Human Immunodeficiency Virus | OriginalPaper

    Validation of human immunodeficiency virus diagnosis codes among women enrollees of a U.S. health plan

    Research on the quality of health care received by persons with human immunodeficiency virus (HIV), and their health outcomes, can be facilitated by efficiently identifying cohorts of patients with HIV using electronic health record (EHR) data …

  18. Open Access 01-12-2024 | Secondary Immunodeficiency | OriginalPaper

    Development of a predictive machine learning model for pathogen profiles in patients with secondary immunodeficiency

    Human immune system plays a crucial role against all kinds of pathogens [ 1 ]. Defects in any components of the immune system lead to immunodeficiency. Depending on the underlying mechanisms, immunodeficiency is categorized as primary and secondary …

  19. Open Access 23-03-2024 | Hypercalcemia | Online First

    Hypercalcemia as a rare manifestation of immune reconstitution inflammatory syndrome (IRIS) in a person living with Human Immunodeficiency Virus (HIV) with disseminated nontuberculous mycobacteriosis

    A 39-year-old male person living with HIV presented to the emergency department with progressive muscle weakness and unintended weight loss of 8 kg within the last 2 weeks. He reported watery stool twice per day for 3 months. There was no fever or …

  20. Open Access 01-12-2024 | Human Immunodeficiency Virus | OriginalPaper

    Assessing high-risk sexual practices associated with human immunodeficiency virus infection among young female sex workers in Lubumbashi, Democratic Republic of the Congo: a cross-sectional study

    In sub-Saharan Africa, adolescent girls and young women (AGYW) aged between 15 and 24 are at a higher risk of being exposed to human immunodeficiency virus (HIV) infection than older women and their male peers. This is particularly true for those …

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