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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Published in:

Open Access 01-12-2021 | COVID-19 | Review

Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review

Authors: Nikita Mohan, Muhammad Ali Fayyaz, Christopher del Rio, Navpreet Kaur Rajinder Singh Khurana, Sampada Sandip Vaidya, Esteban Salazar, John Joyce, Amrat Ayaz Ali

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2021

Abstract

Background

The COVID-19 pandemic has drastically affected everyone in a hit or miss manner. Since it began, evidence of the neuro-invasive potential of the virus has been intensifying significantly. Several pathways have been hypothesized to elucidate the neurotropic nature of SARS-CoV2. It is the need of the hour to collect vital information.

Objective

To evaluate and correlate the neuro-radiological and neurological manifestations in patients diagnosed with SARS-CoV2.

To identify neuro-invasive pathways of COVID infection.

Methods

Relevant studies were identified through four databases—the Cochrane Library, PubMed, Science Direct, and Web of Science. These were searched using relevant keywords—“COVID-19,” “SARS-CoV2,” “neurological manifestations,” “neuroimaging,” “CT,” and “MRI.” Relevant articles were screened according to a pre-defined inclusion and exclusion criteria from December 2019 to August 2020.

Results

Our review included a total of 63 full text publications with 584 patients, composed mainly of observational studies, case reports, and case series. The most common neurological manifestations associated with COVID-19 were altered mental status, stroke, and paralysis. About 17.85% patients who underwent neuroimaging were found to be having ischemic changes suggestive of a stroke. This was followed by hemorrhagic changes as the second most common finding. The most commonly involved vessel was the Middle Cerebral Artery. Besides stroke, we found that SARS-CoV2 could be the cause for new-onset seizures, Guillain-Barre Syndrome, encephalitis, and many other severe neurological diseases.

Conclusion

The information that we have obtained so far will prove dynamic to healthcare providers working against the COVID-19 pandemic. It is necessary to be aware of these atypical neurological findings for the early diagnosis and treatment of COVID-19 infected patients. However, to completely understand the connection between SARS-CoV2 and the nervous system, further research is necessary.

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Title: Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review
Authors: Nikita Mohan
Muhammad Ali Fayyaz
Christopher del Rio
Navpreet Kaur Rajinder Singh Khurana
Sampada Sandip Vaidya
Esteban Salazar
John Joyce
Amrat Ayaz Ali
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keywords: COVID-19
Stroke
Magnetic Resonance Imaging
Magnetic Resonance Imaging
Computed Tomography
Computed Tomography
SARS-CoV-2
Cough
Cough
Cough
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery / Issue 1/2021
Electronic ISSN: 1687-8329
DOI: https://doi.org/10.1186/s41983-021-00322-3

At a glance: The STEP trials

Springer Medicine

Neurological manifestations and neuroimaging findings in patients with SARS-CoV2—a systematic review

Abstract

Background

Objective

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Objective

Methods

Results

Conclusion

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Other articles of this Issue 1/2021

Dilemma of migraine diagnosis and management among non-neurologists

An insight into Alzheimer’s disease and its on-setting novel genes

Serum levels of leptin and adiponectin in patients with multiple sclerosis

Mechanical thrombectomy (MT) for acute ischemic stroke (AIS) in COVID-19 pandemic: a systematic review

Pathophysiology of SARS-CoV-2-associated ischemic stroke is variegated

Could SARS-CoV-2 herald a surge of multiple sclerosis?