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01-11-2020 | Chlamydophila Pneumoniae | Letter to the Editors

Reversible Encephalopathy Syndrome (PRES) in a COVID-19 patient

Authors: Lucia Princiotta Cariddi, Payam Tabaee Damavandi, Federico Carimati, Paola Banfi, Alessandro Clemenzi, Margherita Marelli, Andrea Giorgianni, Gabriele Vinacci, Marco Mauri, Maurizio Versino

Published in: Journal of Neurology | Issue 11/2020

Abstract

Recently WHO has declared novel coronavirus disease 2019 (COVID-19) outbreak a pandemic. Acute respiratory syndrome seems to be the most common manifestation of COVID-19. Besides pneumonia, it has been demonstrated that SARS-CoV-2 infection affects multiple organs, including brain tissues, causing different neurological manifestations, especially acute cerebrovascular disease (ischemic and hemorrhagic stroke), impaired consciousness and skeletal muscle injury. To our knowledge, among neurological disorders associated with SARS-CoV2 infection, no Posterior Reversible Encephalopathy Syndrome (PRES) has been described yet. Herein, we report a case of a 64-year old woman with COVID19 infection who developed a PRES, and we suggest that it could be explained by the disruption of the blood brain barrier induced by the cerebrovascular endothelial dysfunction caused by SARS-CoV-2.

Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, Pessin MS, Lamy C, Mas JL, Caplan LR (1996) A reversible posterior leukoencephalopathy syndrome. N Engl J Med 334(8):494–500. https://doi.org/10.1056/NEJM199602223340803CrossRefPubMed

Bartynski WS, Boardman JF, Zeigler ZR, Shadduck RK, Lister J (2006) Posterior reversible encephalopathy syndrome in infection, sepsis, and shock. AJNR Am J Neuroradiol 27(10):2179–2190PubMedPubMedCentral

Racchiusa S, Mormina E, Ax A, Musumeci O, Longo M, Granata F (2019) Posterior reversible encephalopathy syndrome (PRES) and infection: a systematic review of the literature. Neurol Sci 40(5):915–922. https://doi.org/10.1007/s10072-018-3651-4CrossRefPubMed

Toledano M, Fugate JE (2017) Posterior reversible encephalopathy in the intensive care unit. Handb Clin Neurol 141:467–483. https://doi.org/10.1016/B978-0-444-63599-0.00026-0CrossRefPubMed

Pilato F, Distefano M, Calandrelli R (2020) Posterior reversible encephalopathy syndrome and reversible cerebral vasoconstriction syndrome: clinical and radiological considerations. Front Neurol 11:34. https://doi.org/10.3389/fneur.2020.00034CrossRefPubMedPubMedCentral

Fugate JE, Rabinstein AA (2015) Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions. Lancet Neurol 14(9):914–925. https://doi.org/10.1016/S1474-4422(15)00111-8CrossRefPubMed

Franceschi AM, Ahmed O, Giliberto L, Castillo M (2020) Hemorrhagic posterior reversible encephalopathy syndrome as a manifestation of COVID-19 infection. AJNR Am J Neuroradiol. https://doi.org/10.3174/ajnr.A6595CrossRefPubMedPubMedCentral

Guo J, Huang Z, Lin L, Lv J (2020) Coronavirus disease 2019 (COVID-19) and cardiovascular disease: a viewpoint on the potential influence of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers on onset and severity of severe acute respiratory syndrome coronavirus 2 infection. J Am Heart Assoc 9(7):e016219. https://doi.org/10.1161/JAHA.120.016219CrossRefPubMedPubMedCentral

Sardu C, Gambardella J, Morelli MB, Wang X, Marfella R, Santulli G (2020) Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence. J Clin Med. https://doi.org/10.3390/jcm9051417CrossRefPubMedPubMedCentral

10.

Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, Mehra MR, Schuepbach RA, Ruschitzka F, Moch H (2020) Endothelial cell infection and endotheliitis in COVID-19. Lancet 395(10234):1417–1418. https://doi.org/10.1016/S0140-6736(20)30937-5CrossRefPubMedPubMedCentral

11.

Natoli S, Oliveira V, Calabresi P, Maia LF, Pisani A (2020) Does SARS-Cov-2 invade the brain? Translational lessons from animal models. Eur J Neurol. https://doi.org/10.1111/ene.14277CrossRefPubMedPubMedCentral

Title: Reversible Encephalopathy Syndrome (PRES) in a COVID-19 patient
Authors: Lucia Princiotta Cariddi
Payam Tabaee Damavandi
Federico Carimati
Paola Banfi
Alessandro Clemenzi
Margherita Marelli
Andrea Giorgianni
Gabriele Vinacci
Marco Mauri
Maurizio Versino
Publication date: 01-11-2020
Publisher: Springer Berlin Heidelberg
Keywords: Chlamydophila Pneumoniae
Edema
SARS-CoV-2
COVID-19
Encephalopathy
Posterior Reversible Encephalopathy Syndrome
Published in: Journal of Neurology / Issue 11/2020
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-020-10001-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Reversible Encephalopathy Syndrome (PRES) in a COVID-19 patient

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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