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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 1/2021

Open Access 01-12-2021 | Multiple Sclerosis | Letter to the Editor

Could SARS-CoV-2 herald a surge of multiple sclerosis?

Authors: Nevin Mohieldin Shalaby, Hatem Samir Shehata

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2021

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Abstract

During the current COVID-19 pandemic, many queries are raised regarding its nature, outcome, and sequelae. This letter raises the concern of potential impact on increasing the incidence of multiple sclerosis whose pathology involves a possible viral etiology. Besides, the potential neurotropism of the acute respiratory distress syndrome corona virus-2 (SARS-CoV-2), which is still not established, may raise concerns about the use of certain disease modifying therapies namely natalizumab.
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Doobay MF, Talman LS, Obr TD, Tian X, Davisson RL, et al. Differential expression of neuronal ACE2 in transgenic mice with overexpressionof the brain renin-angiotensin system. Am J Phys Regul Integr Comp Phys. 2007;l292:R373–R38.
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Murray RS, Brown B, Brian D, Cabirac GF. Detection of coronavirus RNA and antigen in multiple sclerosis brain. Ann Neurol. 1992;31:525–33.CrossRef
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Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020;87:18–22.CrossRef
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Giovannoni G, Hawkes C, Lechner-Scott J, Levy M, Waubant E, Gold J. The COVID-19 pandemic and the use of MS disease-modifying therapies. Mult Scler Relat Disord. 2020;39:102073.CrossRef
Metadata
Title
Could SARS-CoV-2 herald a surge of multiple sclerosis?
Authors
Nevin Mohieldin Shalaby
Hatem Samir Shehata
Publication date
01-12-2021
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1186/s41983-021-00277-5

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