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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

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Open Access 01-12-2021 | Stroke | Letter to the Editor

Pathophysiology of SARS-CoV-2-associated ischemic stroke is variegated

Authors: Fulvio A. Scorza, Ana C. Fiorini, Josef Finsterer

Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery | Issue 1/2021

Excerpt

With interest we read the review article by Roushdy et al. about the pathophysiological mechanisms involved in the development of SARS-CoV-2-associated stroke [1]. SARS-CoV-2-associated stroke mechanisms discussed were affection of the renin angiotensin system and angiotensin-converting enzyme 2 (ACE-2) receptor downregulation, endothelial cell damage with coagulopathy, cytokine storm, and platelet dysfunction [1]. The review is appealing but raises the following comments and concerns. …

Roushdy T, Hamid E. A review on SARS-CoV-2 and stroke pathogenesis and outcome. Egypt J Neurol Psychiatr Neurosurg. 2021;57(1):63. https://doi.org/10.1186/s41983-021-00319-y.CrossRefPubMedPubMedCentral

Maab H, Mustafa F, Shabbir SJ. Cardiovascular impact of COVID-19: an array of presentations. Acta Biomed. 2021;92(2): e2021021. https://doi.org/10.23750/abm.v92i2.10299.CrossRefPubMedPubMedCentral

Aguilera-Alonso D, Murias S, Martínez-de-AzagraGarde A, Soriano-Arandes A, Pareja M, Otheo E, Moraleda C, Tagarro A, Calvo C, EPICO-AEP Working Group. Prevalence of thrombotic complications in children with SARS-CoV-2. Arch Dis Child. 2021. https://doi.org/10.1136/archdischild-2020-321351.CrossRefPubMed

Finsterer J, Scorza FA. Guillain-Barre syndrome in 220 patients with COVID-19. Egypt J Neurol Psychiatr Neurosurg. 2021;57(1):55. https://doi.org/10.1186/s41983-021-00310-7.CrossRefPubMedPubMedCentral

Mansoor T, Alsarah AA, Mousavi H, KhaderEliyas J, Girotra T, Hussein O. COVID-19 associated reversible cerebral vasoconstriction syndrome successfully treated with nimodipine and aspirin. J Stroke Cerebrovasc Dis. 2021;30(7): 105822. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105822.CrossRefPubMedPubMedCentral

Barrasa H, Rello J, Tejada S, Martín A, Balziskueta G, Vinuesa C, Fernández-Miret B, Villagra A, Vallejo A, San Sebastián A, Cabañes S, Iribarren S, Fonseca F, Maynar J, Alava COVID-19 Study Investigators. SARS-CoV-2 in Spanish intensive care units: early experience with 15-day survival in Vitoria. Anaesth Crit Care Pain Med. 2020;39(5):553–61. https://doi.org/10.1016/j.accpm.2020.04.001.CrossRefPubMedPubMedCentral

Title: Pathophysiology of SARS-CoV-2-associated ischemic stroke is variegated
Authors: Fulvio A. Scorza
Ana C. Fiorini
Josef Finsterer
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keywords: Stroke
SARS-CoV-2
COVID-19
Posterior Reversible Encephalopathy Syndrome
Guillain-Barré Syndrome
Cardiomyopathy
Myocarditis
Published in: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery / Issue 1/2021
Electronic ISSN: 1687-8329
DOI: https://doi.org/10.1186/s41983-021-00378-1

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