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Open Access 01-12-2021 | Cardiopulmonary Resuscitation | Research article

Hyperoxia during extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest is associated with severe circulatory failure and increased mortality

Authors: Jean Bonnemain, Marco Rusca, Zied Ltaief, Aurélien Roumy, Piergiorgio Tozzi, Mauro Oddo, Matthias Kirsch, Lucas Liaudet

Published in: BMC Cardiovascular Disorders | Issue 1/2021

Abstract

Background

High levels of arterial oxygen pressures (PaO₂) have been associated with increased mortality in extracorporeal cardiopulmonary resuscitation (ECPR), but there is limited information regarding possible mechanisms linking hyperoxia and death in this setting, notably with respect to its hemodynamic consequences. We aimed therefore at evaluating a possible association between PaO₂, circulatory failure and death during ECPR.

Methods

We retrospectively analyzed 44 consecutive cardiac arrest (CA) patients treated with ECPR to determine the association between the mean PaO₂ over the first 24 h, arterial blood pressure, vasopressor and intravenous fluid therapies, mortality, and cause of deaths.

Results

Eleven patients (25%) survived to hospital discharge. The main causes of death were refractory circulatory shock (46%) and neurological damage (24%). Compared to survivors, non survivors had significantly higher mean 24 h PaO₂ (306 ± 121 mmHg vs 164 ± 53 mmHg, p < 0.001), lower mean blood pressure and higher requirements in vasopressors and fluids, but displayed similar pulse pressure during the first 24 h (an index of native cardiac recovery). The mean 24 h PaO₂ was significantly and positively correlated with the severity of hypotension and the intensity of vasoactive therapies. Patients dying from circulatory failure died after a median of 17 h, compared to a median of 58 h for patients dying from a neurological cause. Patients dying from neurological cause had better preserved blood pressure and lower vasopressor requirements.

Conclusion

In conclusion, hyperoxia is associated with increased mortality during ECPR, possibly by promoting circulatory collapse or delayed neurological damage.

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Title: Hyperoxia during extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest is associated with severe circulatory failure and increased mortality
Authors: Jean Bonnemain
Marco Rusca
Zied Ltaief
Aurélien Roumy
Piergiorgio Tozzi
Mauro Oddo
Matthias Kirsch
Lucas Liaudet
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Cardiopulmonary Resuscitation
ECMO
ECMO
Published in: BMC Cardiovascular Disorders / Issue 1/2021
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-021-02361-3

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Springer Medicine

Hyperoxia during extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest is associated with severe circulatory failure and increased mortality

Abstract

Background

Methods

Results

Conclusion

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Abstract

Background

Methods

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Conclusion

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