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Intensive Care Medicine

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Open Access 01-01-2019 | Original

Effect of interplay between age and low-flow duration on neurologic outcomes of extracorporeal cardiopulmonary resuscitation

Authors: Hsi-Yu Yu, Chih-Hsien Wang, Nai-Hsin Chi, Shu-Chien Huang, Heng-Wen Chou, Nai-Kuan Chou, Yih-Sharng Chen

Published in: Intensive Care Medicine | Issue 1/2019

Abstract

Purpose

Caseloads of extracorporeal cardiopulmonary resuscitation (ECPR) have increased considerably, and hospital mortality rates remain high and unpredictable. The present study evaluated the effects of the interplay between age and prolonged low-flow duration (LFD) on hospital survival rates in elderly patients to identify subgroups that can benefit from ECPR.

Methods

Adult patients who received ECPR in our institution (2006–2016) were classified into groups 1, 2, and 3 (18–65, 65–75, and > 75 years, respectively). Data regarding ECPR and adverse events during hospitalization were collected prospectively. The primary end point was favorable neurologic outcome (cerebral performance category 1 or 2) at hospital discharge.

Results

In total, 482 patients were divided into groups 1, 2, and 3 (70.5%, 19.3%, and 10.2%, respectively). LFDs were comparable among the groups (40.3, 41.0, and 44.3 min in groups 1, 2, and 3, P = 0.781, 0.231, and 0.382, respectively). Favorable neurologic outcome rates were nonsignificantly lower in group 3 than in the other groups (27.6%, 24.7%, and 18.4% for group 1, 2, and 3, respectively). Subgroup analysis revealed that the favorable neurologic outcome rates in group 1 were 36.7%, 25.4%, and 13.0% for LFDs of < 30, 30–60, and > 60 min, respectively (P = 0.005); in group 2, they were 32.1%, 21.2%, and 23.1%, respectively (P = 0.548); in group 3 they were 25.0%, 20.8%, and 0.0%, respectively (P = 0.274).

Conclusion

On emergency consultation for ECPR, age and low-flow duration should be considered together to predict neurologic outcome.

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Title: Effect of interplay between age and low-flow duration on neurologic outcomes of extracorporeal cardiopulmonary resuscitation
Authors: Hsi-Yu Yu
Chih-Hsien Wang
Nai-Hsin Chi
Shu-Chien Huang
Heng-Wen Chou
Nai-Kuan Chou
Yih-Sharng Chen
Publication date: 01-01-2019
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 1/2019
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-018-5496-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Effect of interplay between age and low-flow duration on neurologic outcomes of extracorporeal cardiopulmonary resuscitation

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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