Issue 4/2020
Mutant KRAS: Hidden Secrets of an Oncogene
Content (19 Articles)
Metastasis is a highly stressful process
Alejandro D. Campos, Sara M. Weis, David A. Cheresh
Molecular epidemiology and diagnostics of KRAS mutations in human cancer
Jozsef Timar, Karl Kashofer
The effects of mutant Ras proteins on the cell signalome
Tamás Takács, Gyöngyi Kudlik, Anita Kurilla, Bálint Szeder, László Buday, Virag Vas
Novel regulation of Ras proteins by direct tyrosine phosphorylation and dephosphorylation
László Buday, Virág Vas
Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery
Gyula Pálfy, Dóra K. Menyhárd, András Perczel
Structure-based inhibitor design of mutant RAS proteins—a paradigm shift
Kinga Nyíri, Gergely Koppány, Beáta G. Vértessy
Small molecule inhibitors of RAS proteins with oncogenic mutations
Zoltán Orgován, György M. Keserű
K-Ras prenylation as a potential anticancer target
Marcell Baranyi, László Buday, Balázs Hegedűs
Current therapy of advanced colorectal cancer according to RAS/RAF mutational status
Gábor Lakatos, Claus-Henning Köhne, György Bodoky
Current therapy of KRAS-mutant lung cancer
Aron Ghimessy, Peter Radeczky, Viktoria Laszlo, Balazs Hegedus, Ferenc Renyi-Vamos, Janos Fillinger, Walter Klepetko, Christian Lang, Balazs Dome, Zsolt Megyesfalvi
Gastric cancer: a comprehensive review of current and future treatment strategies
Rachel E. Sexton, Mohammed Najeeb Al Hallak, Maria Diab, Asfar S. Azmi
Platelets in aging and cancer—“double-edged sword”
Alessandra V. S. Faria, Sheila S. Andrade, Maikel P. Peppelenbosch, Carmen V. Ferreira-Halder, Gwenny M. Fuhler
Molecular mediators of peritoneal metastasis in pancreatic cancer
Leela Rani Avula, Brendan Hagerty, Christine Alewine
Rho GTPases in cancer radiotherapy and metastasis
Rui-Jie Zeng, Chun-Wen Zheng, Wan-Xian Chen, Li-Yan Xu, En-Min Li