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Published in: Journal of Neurology 2/2024

Open Access 31-10-2023 | Aphasia | Neurological Update

Primary progressive aphasia: six questions in search of an answer

Authors: Christopher R. S. Belder, Charles R. Marshall, Jessica Jiang, Salvatore Mazzeo, Anthipa Chokesuwattanaskul, Jonathan D. Rohrer, Anna Volkmer, Chris J. D. Hardy, Jason D. Warren

Published in: Journal of Neurology | Issue 2/2024

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Abstract

Here, we review recent progress in the diagnosis and management of primary progressive aphasia—the language-led dementias. We pose six key unanswered questions that challenge current assumptions and highlight the unresolved difficulties that surround these diseases. How many syndromes of primary progressive aphasia are there—and is syndromic diagnosis even useful? Are these truly ‘language-led’ dementias? How can we diagnose (and track) primary progressive aphasia better? Can brain pathology be predicted in these diseases? What is their core pathophysiology? In addition, how can primary progressive aphasia best be treated? We propose that pathophysiological mechanisms linking proteinopathies to phenotypes may help resolve the clinical complexity of primary progressive aphasia, and may suggest novel diagnostic tools and markers and guide the deployment of effective therapies.
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Metadata
Title
Primary progressive aphasia: six questions in search of an answer
Authors
Christopher R. S. Belder
Charles R. Marshall
Jessica Jiang
Salvatore Mazzeo
Anthipa Chokesuwattanaskul
Jonathan D. Rohrer
Anna Volkmer
Chris J. D. Hardy
Jason D. Warren
Publication date
31-10-2023
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 2/2024
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-023-12030-4

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