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Journal of Neurology
Published in: Journal of Neurology 6/2018

Open Access 01-06-2018 | Neurological Update

Primary progressive aphasia: a clinical approach

Authors: Charles R. Marshall, Chris J. D. Hardy, Anna Volkmer, Lucy L. Russell, Rebecca L. Bond, Phillip D. Fletcher, Camilla N. Clark, Catherine J. Mummery, Jonathan M. Schott, Martin N. Rossor, Nick C. Fox, Sebastian J. Crutch, Jonathan D. Rohrer, Jason D. Warren

Published in: Journal of Neurology | Issue 6/2018

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Abstract

The primary progressive aphasias are a heterogeneous group of focal ‘language-led’ dementias that pose substantial challenges for diagnosis and management. Here we present a clinical approach to the progressive aphasias, based on our experience of these disorders and directed at non-specialists. We first outline a framework for assessing language, tailored to the common presentations of progressive aphasia. We then consider the defining features of the canonical progressive nonfluent, semantic and logopenic aphasic syndromes, including ‘clinical pearls’ that we have found diagnostically useful and neuroanatomical and other key associations of each syndrome. We review potential diagnostic pitfalls and problematic presentations not well captured by conventional classifications and propose a diagnostic ‘roadmap’. After outlining principles of management, we conclude with a prospect for future progress in these diseases, emphasising generic information processing deficits and novel pathophysiological biomarkers.
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Metadata
Title
Primary progressive aphasia: a clinical approach
Authors
Charles R. Marshall
Chris J. D. Hardy
Anna Volkmer
Lucy L. Russell
Rebecca L. Bond
Phillip D. Fletcher
Camilla N. Clark
Catherine J. Mummery
Jonathan M. Schott
Martin N. Rossor
Nick C. Fox
Sebastian J. Crutch
Jonathan D. Rohrer
Jason D. Warren
Publication date
01-06-2018
Publisher
Springer Berlin Heidelberg
Published in
Journal of Neurology / Issue 6/2018
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-018-8762-6

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