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Aphasia 

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  1. Open Access 01-12-2024 | Aphasia | OriginalPaper

    Utility of visual rating scales in primary progressive aphasia

    Primary progressive aphasias (PPA) are a group of neurodegenerative conditions characterized by progressive degeneration of the language. The current criteria recognize three variants of PPA: semantic variant PPA (svPPA), characterized by gradual …

  2. 12-04-2024 | Aphasia | Online First

    The role of language-related functional brain regions and white matter tracts in network plasticity of post-stroke aphasia

    The neural mechanisms underlying language recovery after a stroke remain controversial. This review aimed to summarize the plasticity and reorganization mechanisms of the language network through neuroimaging studies. Initially, we discussed the …

  3. 07-04-2024 | Apraxia | Online First

    Progression to corticobasal syndrome: a longitudinal study of patients with nonfluent primary progressive aphasia and primary progressive apraxia of speech

    Primary progressive apraxia of speech (PPAOS) is a motor speech disorder with insidious onset in which patients present with apraxia of speech (AOS) as the only initial symptom resulting from focal atrophy of the premotor cortex [ 1 ]. The main …

  4. Open Access 04-03-2024 | Aphasia | Online First

    Cerebellar compensation: a case of aphasia due to cerebellar hemorrhage

  5. Open Access 01-12-2024 | Aphasia | OriginalPaper

    Meta-analysis and systematic review of the relationship between sex and the risk or incidence of poststroke aphasia and its types

    Stroke is the second leading cause of death in the world, and poststroke aphasia (PSA) is a common sequela of stroke patients [ 1 , 2 ]. PSA is a speech disorder caused by the impairment of the language function area of the dominant hemisphere. The …

  6. Open Access 01-12-2024 | Aphasia | OriginalPaper

    Heterogeneity and overlap in the continuum of linguistic profile of logopenic and semantic variants of primary progressive aphasia: a Profile Analysis based on Multidimensional Scaling study

    Current criteria for diagnosis of logopenic/phonological variant of primary progressive aphasia (PPA) (lvPPA) [ 1 ] describe core (impaired single word retrieval and sentence repetition) and secondary (phonological errors, spared semantic …

  7. Open Access 31-10-2023 | Aphasia | Review

    Primary progressive aphasia: six questions in search of an answer

    Despite considerable clinical and research attention, language-led dementias remain mysterious disorders. This review explores six key questions that challenge assumptions about primary progressive aphasia.

  8. Open Access 20-01-2024 | Aphasia | Online First

    Cerebellar-Induced Aphasia After Stroke: Evidence for the “Linguistic Cerebellum”

    The cerebellum is traditionally known to subserve motor functions. However, for several decades, the concept of the “cerebellar cognitive affective syndrome” has evolved. Studies in healthy participants and patients have confirmed the cerebellar …

  9. Open Access 02-11-2023 | Frontotemporal Dementia | OriginalPaper

    Differential patterns of lysosomal dysfunction are seen in the clinicopathological forms of primary progressive aphasia

    Increasing evidence implicates endo-lysosomal dysfunction in frontotemporal dementia (FTD). 18 proteins were quantified using a mass spectrometry assay panel in the cerebrospinal fluid of 36 people with the language variant of FTD, primary …

  10. Open Access 01-12-2024 | Repetitive Transcranial Magnetic Stimulation | ReviewPaper

    A literature review and meta-analysis of the optimal factors study of repetitive transcranial magnetic stimulation in post-infarction aphasia

    Aphasia is a neurological condition characterized by impaired language understanding and expression. It typically develops because of damage to the brain's language centers or associated networks [ 1 ]. Brain tumors, traumatic brain injury, and …

  11. 30-12-2023 | Aphasia | Online First

    Network-based statistics distinguish anomic and Broca’s aphasia

    Aphasia is a speech-language disorder that commonly develops after a left-hemisphere stroke and can affect a person’s ability to read, understand, and speak a language. According to the National Aphasia Association, aphasia currently affects over …

  12. Open Access 01-12-2023 | Aphasia | OriginalPaper

    The neural substrates of transdiagnostic cognitive-linguistic heterogeneity in primary progressive aphasia

    Primary progressive aphasias (PPA) are a heterogeneous group of neurodegenerative disorders of language [ 1 , 2 ]. Three principal clinical variants are described: a semantic variant (svPPA or semantic dementia) displaying profound conceptual …

  13. 23-01-2023 | Aphasia | BriefCommunication

    Mixed Aphasia Caused by Bilateral Cerebellar Infarcts: a Case Report

    Although neuroanatomical and physiological understanding of the cerebellum has evolved over recent decades and continues to develop, there is much that remains to be expounded upon, especially with regard to nonmotor roles. Neurocognitive and …

  14. Open Access 01-12-2023 | Magnetic Resonance Imaging | OriginalPaper

    Clinical features and biomarkers of semantic variant primary progressive aphasia with MAPT mutation

    Frontotemporal lobar degeneration (FTLD) is second only to Alzheimer’s disease (AD) as the most common cause of early-onset dementia [ 1 , 2 ]. According to its clinical features, FTLD is usually classified into two major phenotypes: behavioural …

  15. 24-11-2023 | Aphasia | OriginalPaper

    Impairment of the internal forward model and feedback mechanisms for vocal sensorimotor control in post-stroke aphasia: evidence from directional responses to altered auditory feedback

    The present study examined opposing and following vocal responses to altered auditory feedback (AAF) to determine how damage to left-hemisphere brain networks impairs the internal forward model and feedback mechanisms in post-stroke aphasia.

  16. Open Access 01-12-2023 | Aphasia | ReviewPaper

    Effects of primary motor cortex noninvasive brain stimulation on post-stroke aphasia: a narrative review

    Aphasia is one of the most debilitating impairments after stroke, significantly affecting patients’ comprehension, communication, functional recovery, and overall quality of life. There are numerous strategies for treating aphasia in post-stroke …

  17. Open Access 01-12-2023 | Repetitive Transcranial Magnetic Stimulation | OriginalPaper

    Improved language function for post-stroke aphasia in the long term following repeated repetitive transcranial magnetic stimulation and intensive speech-language-hearing therapy: a case report

    Around 21% to 40% of stroke patients sustain permanent aphasia [ 1 ]. Stroke survivors with acquired language disability are generally thought to reach a plateau within a year of stroke onset, after which their residual language abilities stabilize …

  18. Open Access 01-03-2022 | Frontotemporal Dementia | OriginalPaper

    The natural history of primary progressive aphasia: beyond aphasia

    Since the original description of the clinical syndrome of primary progressive aphasia (PPA) in six patients by Marsel Mesulam in 1982 [ 1 ], studies have focused on defining its clinical phenotypes, underlying molecular pathologies, and genetic …

  19. 01-05-2023 | Aphasia | OriginalPaper

    Point-light display: a new tool to improve verb recovery in patients with aphasia? A pilot study

    Some studies have demonstrated that Action Observation (AO) could help patients with aphasia to recover use of verbs. However, the role of kinematics in this effect has remained unknown. The main aim was to assess the effectiveness of a …

  20. Open Access 01-12-2022 | Magnetic Resonance Imaging | OriginalPaper

    Cortical microstructure in primary progressive aphasia: a multicenter study

    Primary progressive aphasia (PPA) encompasses different neurodegenerative syndromes characterized by prominent deterioration of speech and language, and relative sparing of other cognitive functions [ 1 , 2 ]. In 2011, an international group of …

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