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Virology Journal
Published in: Virology Journal 1/2019

Open Access 01-12-2019 | Zika Virus | Review

Association of N6-methyladenosine with viruses and related diseases

Authors: Fang Wu, Wenzhao Cheng, Feiyuan Zhao, Mingqing Tang, Yong Diao, Ruian Xu

Published in: Virology Journal | Issue 1/2019

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Abstract

Background

N6-methyladenosine (m6A) modification is the most prevalent internal modification of eukaryotic mRNA modulating gene expression. m6A modification is a dynamic reversible process regulated by three protein groups: methyltransferases (writers), demethylases (erasers), and m6A-binding proteins (readers). m6A modification is involved in all phases of RNA metabolism, including RNA folding, stability, splicing, nuclear exporting, translational modulation and degradation.

Main body

In recent years, numerous studies have reported that abnormal m6A modification causes aberrant expression of important viral genes. Herein, we review the role of m6A in viral lifecycle and its contribution to the pathogenesis of human diseases. Particularly, we focus on the viruses associated with human diseases such as HIV-1, IAV, HBV, HCV, EBV and many others.

Conclusions

A better understanding of m6A-virus relationship would provide new insights into the viral replication process and pathogenesis of human diseases caused by viruses. In addition, exploration of the role of m6A in disease-causing viruses will reveal novel approaches for the treatment of such diseases.
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Metadata
Title
Association of N6-methyladenosine with viruses and related diseases
Authors
Fang Wu
Wenzhao Cheng
Feiyuan Zhao
Mingqing Tang
Yong Diao
Ruian Xu
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2019
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-019-1236-3

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