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Valvular Heart Disease

COMPAR(ing)-TAVI: Myval comparable to SAPIEN 3 THVs

Myval noninferior to SAPIEN 3 transcatheter heart valves for patients undergoing transfemoral transcatheter aortic valve implantation, suggests COMPARE-TAVI study.

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Editor's Choice

Dapagliflozin benefits older people undergoing TAVI

Dapagliflozin after transcatheter aortic valve implantation for aortic stenosis significantly decreases the risk for death or worsening heart failure versus standard care.

Percutaneous treatment for obstructive HCM with severe MR

Surgical intervention is typically used to treat HCM with severe mitral regurgitation but can be high risk. MitraClip combined with PTSBME was successfully performed in this patient with obstructive HCM and severe MR.

Recurrent strokes after TAVR in patient with BAV

TAVR use has increased in low-risk patients, but serious complications can still occur. An elderly patient underwent TAVR to treat severe bicuspid aortic valve stenosis but experienced multiple strokes 6 months later.

Adding transcatheter repair to tricuspid regurgitation treatment improves outcomes

The addition of tricuspid transcatheter edge-to-edge repair to optimized medical therapy for severe tricuspid regurgitation improves clinical and patient-reported outcomes.

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Keynote webinar | Spotlight on cardio-oncology

An expert-led symposium exploring the most pertinent issues in cardio-oncology, with a focus on the new ESC guidelines. Highlights include preventative approaches in cardio-oncology, toxicity risk-stratification strategies, the clinical management of myocarditis as an adverse effect of immune checkpoint inhibitor-treatments, and the utility of biomarkers in long-term follow-up of cardiovascular disease risk in cancer patients.

Prof. Rudolf de Boer
Prof. Lorenz Lehmann
Dr. Teresa Lopéz Fernández
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Video

Case Studies

Percutaneous treatment for obstructive HCM with severe MR

Surgical intervention is typically used to treat HCM with severe mitral regurgitation but can be high risk. MitraClip combined with PTSBME was successfully performed in this patient with obstructive HCM and severe MR.

Recurrent strokes after TAVR in patient with BAV

TAVR use has increased in low-risk patients, but serious complications can still occur. An elderly patient underwent TAVR to treat severe bicuspid aortic valve stenosis but experienced multiple strokes 6 months later.

Worsening heart failure in a survivor of cancer as a young adult

Severe cardiomyopathy presenting 20 years after anthracycline treatment for non-Hodgkin’s lymphoma during early adulthood. The patient's worsening heart failure was successfully managed with multidrug treatment with add-on vericiguat and ivabradine based on quadruple therapy. 

Current Reviews

Coronary CTA and CT-FFR in trans-catheter aortic valve implantation candidates: a systematic review and meta-analysis

Originally, trans-catheter aortic valve implantation (TAVI) was reserved for patients in whom surgical aortic valve replacement was contra-indicated; however, it is increasingly used in younger and lower-risk patients [ 1 – 3 ]. TAVI candidates …

Preoperative visit-care for transcatheter aortic valve replacement: a review

Transcatheter Aortic Valve Replacement (TAVR), also known as Transcatheter Aortic Valve Implantation (TAVI), is a leading minimally invasive interventional operation to treat patients with aortic stenosis [ 1 ]. In 2002, the world’s first TAVR …

Cardio-Rheumatology: From Inflammation to Heart Failure. The Emerging Role of Cardiovascular Magnetic Resonance Imaging

Many acute and chronic conditions, such as traditional CVD risk factors, emotional/physical stress, autoimmune diseases, microbial/viral infections and ageing, can provoke endothelial alterations. This promotes a low-grade inflammation, which …

Could SGLT2 inhibitors improve outcomes in patients with heart failure and significant valvular heart disease? Need for action

Delivering valvular intervention for all eligible patients with valvular heart disease (VHD) in a timely manner remains a challenge. Therefore, a high number of patients with heart failure (HF) and VHD receive pharmacotherapy while awaiting …

Further Reading

Mutational landscape and impact of clonal hematopoiesis of indeterminate potential in severe aortic valve stenosis

With an estimated population-wide prevalence of 0.5%, and prevalences of 2–9% in populations aged over 75 years [ 1 ], aortic valve stenosis (AVS) constitutes the most common acquired cardiac valve dysfunction and is understood to be the …

Diagnosing Severe Low-Gradient vs Moderate Aortic Stenosis with Artificial Intelligence Based on Echocardiography Images

Diagnosis of aortic valve stenosis (AS) is performed manually by a physician experienced in echocardiography imaging. A specific subtype of AS, a severe low-gradient AS, is the most challenging one in terms of differentiating it from the moderate …

Transcatheter aortic valve replacement in heavily calcified aortic valve stenosis: a multicenter comparison

Transcatheter aortic valve replacement (TAVR) has emerged as an alternative to surgical aortic valve replacement (SAVR) for the majority of patients with severe symptomatic aortic valve stenosis (AS) across the whole spectrum of surgical risk [ 1 …2

Sex-related hormonal variances and clinical outcomes in TAVR patients

Aortic valve stenosis (AS) is one of the most common valvular heart disorders and the prevalence is expected to further increase as the population ages. Once symptomatic, patients with severe AS have significantly increased rates of morbidity and …