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Valvular Heart Disease

Open Access Cardiac Amyloidosis Review

Future horizons in cardiac amyloidosis treatment

New treatment approaches for cardiac amyloidosis are emerging. Discover all the late-stage clinical trials covering RNA silencers, antibodies, and genetic therapy.

Editor's Choice

Frozen elephant trunk technique

Open Access Aortic Dissection Case Study

Successful use of the frozen elephant surgical technique in a patient with acute aortic dissection, with full recovery and no incidence of any neurological side effects.

Asymptomatic quadricuspid aortic valves

Open Access Congenital Heart Anomaly Case Study

Quadricuspid aortic valve is a rare congenital anomaly characterized by the presence of four cusps instead of the usual three. The two cases described here remained asymptomatic until their seventh decade.

Applying AI to the humble ECG

AI interpretation of ECGs could revolutionize cardiac care. Discover current applications from diagnosis of structural abnormalities to prediction of future acute events.

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Webinar | 16-05-2023 | 17:30 (CEST)

Keynote webinar | Spotlight on cardio-oncology

An expert-led symposium exploring the most pertinent issues in cardio-oncology, with a focus on the new ESC guidelines. Highlights include preventative approaches in cardio-oncology, toxicity risk-stratification strategies, the clinical management of myocarditis as an adverse effect of immune checkpoint inhibitor-treatments, and the utility of biomarkers in long-term follow-up of cardiovascular disease risk in cancer patients.

Prof. Rudolf de Boer
Prof. Lorenz Lehmann
Dr. Teresa Lopéz Fernández

Case Studies

Frozen elephant trunk technique

Open Access Aortic Dissection Case Study

Successful use of the frozen elephant surgical technique in a patient with acute aortic dissection, with full recovery and no incidence of any neurological side effects.

Asymptomatic quadricuspid aortic valves

Open Access Congenital Heart Anomaly Case Study

Quadricuspid aortic valve is a rare congenital anomaly characterized by the presence of four cusps instead of the usual three. The two cases described here remained asymptomatic until their seventh decade.

Bacterial endocarditis caused by contact lens use

Open Access Endocarditis Case Study

A 17-year-old female presented with high fever, general fatigue, and dim eyesight. She had used colored contact lenses 3 weeks previously. Traumatic injury of the eye vessels led to systemic hematogenous infection and subsequent endocarditis. 

Current Reviews

Rheumatic Mitral Stenosis: Update in Diagnosis and Evaluation

Rheumatic MS remains a serious health concern, particularly affecting children and young adults in low-to-middle income countries. It is important to suspect the diagnosis in symptomatic patients, particularly those with dyspnea and cardiac …

Gender Disparities in Valvular Heart Disease and Treatment in the Aging Population

Available data demonstrate significant gender-related differences in clinical presentation, treatment, and outcomes for patients with valvular heart disease (VHD). It is also well-established that men and women exhibit different risk profiles …

Penicillin Allergy Testing and Delabeling for Patients Who Are Prescribed Penicillin: A Systematic Review for a World Health Organization Guideline

Open Access Penicillins Review

Secondary prevention with penicillin aims to prevent further episodes of acute rheumatic fever and subsequent development of rheumatic heart disease (RHD). Penicillin allergy, self-reported by 10% of the population, can affect secondary prevention …

Incremental diagnostic and prognostic utility of left atrial deformation in heart failure using speckle tracking echocardiography

Left atrium (LA) is a very important component of cardiovascular performance. The assessment of LA function has gathered the interest with expanding research supporting the utility as a biomarker for outcomes in heart failure (HF).

Further Reading

Beyond prevalence: significance and differential impact of echocardiographic abnormalities in dialysis patients

Open Access Peritoneal Dialysis Original Article

Kidney failure patients have a high mortality rate, with cardiovascular disease being the leading cause [ 1 ]. The kidneys have an essential role in maintaining blood pressure and eliminating waste products and surplus fluids from the body.

Penicillin Allergy Testing and Delabeling for Patients Who Are Prescribed Penicillin: A Systematic Review for a World Health Organization Guideline

Open Access Penicillins Review

Secondary prevention with penicillin aims to prevent further episodes of acute rheumatic fever and subsequent development of rheumatic heart disease (RHD). Penicillin allergy, self-reported by 10% of the population, can affect secondary prevention …

Prevalence of elevated lipoprotein(a) in cardiac rehabilitation patients — results from a large-scale multicentre registry in Germany

Open Access Myocardial Infarction Original Paper

Myocardial infarctions in younger people are considered rare events but occur more frequently than generally assumed. It had been shown in 2015 that 1 in 15 myocardial infarctions affect a patient younger than 45 years; the majority of these are …

Application of Transthoracic Echocardiography for Cardiac Safety Evaluation in the Clinical Development Process of Vaccines Against Streptococcus pyogenes

Open Access Transthoracic Echocardiography Current Opinion

Superficial infections with Streptococcus pyogenes (Strep A), pharyngitis and impetigo can induce acute rheumatic fever, an autoimmune sequela manifesting mostly with arthritis and rheumatic carditis. Valvular heart damage can persist or advance …