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Indian Journal of Pediatrics

12-12-2023 | Kawasaki Disease | Review Article

The Intricate Dance of Infections and Autoimmunity: An Interesting Paradox

Authors: Anand Prahalad Rao, Debasis Patro

Published in: Indian Journal of Pediatrics

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Abstract

Besides genetic susceptibility, infections due to viruses, bacteria and protozoa have been implicated in the development of autoimmune diseases (AD). AD can be triggered in a genetically susceptible individual by infections that disrupt immunological tolerance towards self-antigens. Pathogens can initiate autoimmunity by way of molecular mimicry, bystander activation, epitope spreading or persistent infection with polyclonal activation. This review covers two main topics: (i) the mechanisms by which an infectious agent can trigger or worsen autoimmunity; and (ii) the correlation between specific infectious agents and AD in humans with special emphasis on multisystem inflammatory syndrome in children (MIS-C).
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Metadata
Title
The Intricate Dance of Infections and Autoimmunity: An Interesting Paradox
Authors
Anand Prahalad Rao
Debasis Patro
Publication date
12-12-2023
Publisher
Springer India
Published in
Indian Journal of Pediatrics
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-023-04928-8